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  6. Lipid nanoparticle automatic synthesis system Sunshine

Lipid nanoparticle automatic synthesis system Sunshine

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Lipid nanoparticle automatic synthesis system Sunshine

last updated:Sep 02, 2025

Unchained Labs (アンチェインドラブズ)
Unchained Labs (アンチェインドラブズ)
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Efficient mass production of LNPs - Supporting everything from small-scale condition testing to scale-up.

Once we succeed in finding the optimal formulation conditions for sunscreen, let's use Sunshine to adjust the size of the LNP. Furthermore, we will optimize the protocols and processes for scaling up. We will find the ideal flow rate and explore different mixing options. Next, we will adjust these to the appropriate dilution factor that can keep them stable. Once everything is in place, Sunshine will transition to continuous mode, allowing us to produce several dozen liters in a day. In other words, we will achieve process development and scaling up on a single platform. Many researchers have likely been looking forward to the birth of such a groundbreaking system. • 10 experiments in 15 minutes • Fraction & total flow • From 1 mL to continuous flow • Flow rate 0.1 to 30 mL/min • Reusable microfluidic chips • Possible transition of protocols from sunscreen

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Sunshine

Lipid nanoparticle automatic synthesis system Sunshine

Sunshine front no warning label..png
Sunshine front no warning label..png Picture1.png Picture3.png Picture4.png Sunshine front right no warning label..png Automated Collector front right no warning label.png Automated Sample Valve front left.png Sunshine rear.png
  • Related Link - https://www.unchainedlabs.com/sunscreen/
  • Special site - Product/service details - https://pr.mono.ipros.com/unchainedlabsjp/product/

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Throughput: 10 samples in 15 minutes Total flow rate range: 0.1 to 30 mL/min (depending on the chip) Flow ratio (water to organic) range: 1:1 to 10:1 Standard sample volume range (when FRR is 3:1): 1 to 6.5 mL Minimum input volume (including dead volume): 320 μL Continuous mode capacity range: 20 mL to infinity in continuous mode Inline dilution: Yes Standard particle size range: 40 to 200 nm* PDI: Less than 0.2* Encapsulation efficiency: Over 90%*

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High-throughput screening LNP Drug delivery Gene therapy

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Lipid nanoparticle automatic synthesis system Sunshine

Lipid nanoparticle automatic synthesis system Sunshine

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Benefits of LNP Automated Process Optimization Using Sunshine - Columbia University Case Study

Benefits of LNP Automated Process Optimization Using Sunshine - Columbia University Case Study

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Automatic Synthesis and Screening System for Lipid Nanoparticles Sunscreen

Automatic Synthesis and Screening System for Lipid Nanoparticles Sunscreen

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Accelerating LNP formulation screening using automatic microfluidic technology for sunscreen.

Accelerating LNP formulation screening using automatic microfluidic technology for sunscreen.

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Process optimization of lipid nanoparticles using Sunshine and production of lipid nanoparticles for preclinical use.

Process optimization of lipid nanoparticles using Sunshine and production of lipid nanoparticles for preclinical use.

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Flexibility in Nanoparticle Development by Sunshine: Process Optimization and Scale-Up of Synthetic Nanomedicine

Flexibility in Nanoparticle Development by Sunshine: Process Optimization and Scale-Up of Synthetic Nanomedicine

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[Application Note] Accelerating LNP Product Development with Sun Series at Lightning Speed

[Application Note] Accelerating LNP Product Development with Sun Series at Lightning Speed

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Let's count, size, and quantify RNA with Stunner using LNP.

Let's count, size, and quantify RNA with Stunner using LNP.

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News about this product(14)

[Free Webinar] Bringing Hope to the Challenges of LNP Research and Development, Sunshine Series & Stunner AF

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The development of lipid nanoparticles (LNPs) requires flexible tools that can consistently handle everything from screening to GMP manufacturing. An ideal manufacturing tool must accommodate small-scale, user-friendly experiments as well as multi-parameter, multi-sample, and even large-scale continuous operations. However, the creation of lipid nanoparticles (LNPs) is only half the goal; evaluating characteristics such as encapsulation efficiency (EE%), payload quantification, particle size, and PDI is also essential. Our Sunshine series and Stunner AF (Add Fluorescence) enable scalable nanoparticle manufacturing and powerful all-in-one characterization. In this webinar, we will introduce scalable LNP manufacturing with Sunshine and one-stop measurements of EE%, total RNA quantification, particle size, PDI, and particle concentration with Stunner AF. Experience solutions that will take nanoparticle development to the next level, from research to industrial applications.

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[Free Webinar] Revolutionizing LNP Development: Smooth Technology Transfer for High-Speed and High-Precision Formulation Exploration and Manufacturing

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**[Issue]** The evolution of LNPs is progressing more rapidly than ever, largely due to modifications in particle formulations. However, the formulations to be tested are complex in composition and involve a vast number of combinations, making large-scale screening difficult to achieve. Furthermore, there is the subsequent challenge of transferring to production. Evaluations are also required to be accurate, comprehensive, and high-throughput. **[Webinar Overview]** In this webinar, we will explain how our Sun series can accelerate the exploration and development of LNPs, based on the latest research findings and user case studies in LNP formulations. We will also introduce Stunner, which enables high-speed and accurate LNP evaluations.

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We will exhibit at the DDS Society academic conference.

  • Seminar・Event

Unchained Labs, Inc. will exhibit at the 41st Annual Meeting of the Japanese DDS Society, which will be held from June 17 (Tuesday). At our booth, you can see a wide range of products, from the manufacturing of lipid nanoparticles (LNP) to their characterization, as well as products for ADC and the evaluation of extracellular vesicles. Additionally, on the first day of the event, July 17, we will also hold a presentation by exhibiting companies. All of our staff sincerely look forward to your visit. Event Name: 41st Annual Meeting of the Japanese DDS Society Date: July 17 (Tuesday) - July 18 (Wednesday) Venue: Makuhari Messe International Conference Hall Details: https://procomu.jp/dds2025/ <Exhibiting Company Presentation> July 17 (Tuesday) around 15:28

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CPhI Japan Exhibition & Seminar!

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CPhI Japan Exhibition & Seminar! April 9 (Wednesday) - 11 (Friday) @ Tokyo Big Sight Unchained Labs, Inc. will be exhibiting in the biopharmaceutical zone at CPhI Japan this year as well. Additionally, we will hold a seminar on the second day! Please visit our booth at Tokyo Big Sight. <Exhibitor Seminar> Date and Time: April 10 (Thursday) 13:00-13:30 Venue: 5B "Stability Evaluation of Biopharmaceuticals - Towards a New Era of High-Speed and High-Throughput" *No prior reservation required, free of charge.

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Unchained

Unchained Labs (アンチェインドラブズ)

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Unchained Labs is a company headquartered in Silicon Valley, California, that provides next-generation life science tools. - A lineup of automation devices for biopharmaceutical research, gene therapy, and organic synthesis - Founded in 2015 - Locations in California, New Jersey, Boston, the UK, Brussels, Germany, Shanghai, and Japan - Established a Japanese subsidiary in July 2017

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