[Free Webinar] Revolutionizing LNP Development: Smooth Technology Transfer for High-Speed and High-Precision Formulation Exploration and Manufacturing

Quality assessment of proteins, nucleic acids, AAV, LNP, etc. is possible with trace amounts and high throughput.

"Stunner" is a product that allows simultaneous acquisition of UV/Vis concentration, dynamic light scattering (DLS), and static light scattering (SLS) data from a 2μL identical sample. It enables detailed investigation of AAV and adenoviruses to measure total capsid titer and Empty/Full ratios, as well as to obtain payload concentration and size data of lipid nanoparticles all at once. You can analyze concentration, hydrodynamic size, polydispersity, and the presence of aggregates collectively, allowing you to assess the quality of proteins. This way, you can immediately determine whether your AAV, adenoviruses, lipid nanoparticles, or proteins are suitable for your purposes. [Features] ■ Measure up to 96 samples in a batch in 60 minutes*/12 minutes** *When measured by DLS **When measured by UV/Vis only [Applications] ■ AAV/Adenovirus capsid titer ■ AAV/Adenovirus Empty/Full ratio ■ Lipid nanoparticle (LNP) payload amount ■ Aggregate measurement ■ Concentration measurement ■ Sizing & polydispersity ■ B22 & kD *For more details, please refer to the PDF document or feel free to contact us.

• Other protein analysis

Introducing the details of the newly launched LNP production and screening device.

Researchers of lipid nanoparticles (LNPs) spend a tremendous amount of time on screening, optimization, and scaling up experiments to achieve optimal performance, spot-on targeting, and controlled release of active pharmaceutical ingredients (APIs). Factors such as solubility, pH stability, payload release, and encapsulation all depend on particle size, shape, and structure. In other words, to obtain the right formulation, it is necessary to explore a vast number of formulation parameters and process parameters one by one, and even if a perfect formulation is found, scaling up usually means switching equipment and re-optimizing settings. In this webinar, we will introduce a platform, Sunny Suite, that can reduce the time spent on these LNP formulations. ■ Date and Time: February 26 (Monday) 14:00~ ■ Speaker: Yuji Senoo, Field Application Scientist, Unchained Labs, Inc. ■ Register here: https://unchainedlabs.zoom.us/webinar/register/3217065146675/WN_U1o3xQoZRAKHN-A-7b1yqg

• Other protein analysis

Seamlessly transition from formulation condition screening to scale-up and GMP manufacturing. Accelerate LNP product development.

The development of lipid nanoparticles (LNPs) faces many challenges. The formulation, optimization, and scale-up for clinical trials are complex, costly, and a race against time. Our LNP solutions are designed to accelerate all steps of LNP synthesis and characterization. Sunscreen accelerates LNP formulation screening by reducing costs and time, generating up to 96 unique LNP formulations within 6 hours. Next, using Sunshine, you can develop, optimize, and scale up protocols with the appropriate formulations obtained from Sunscreen. When it comes to the clinical trial phase, Sunbather can accommodate LNP production in a GMP environment using the same processes and microfluidic chips (Sunny) utilized by Sunscreen and Sunshine. In this way, the Sun series allows for a seamless transition from screening formulation conditions to scale-up and GMP manufacturing, as they all use the same pumps and microchannel chips. *For product details, please download various materials.

• Other Physics and Chemistry Equipment

Accelerating formulation optimization for vaccine and pharmaceutical development.

The transition from LNP to GMP is a costly and complicated process. Typically, this requires switching equipment, using different flow paths and mixing devices, and essentially re-developing and re-validating everything that has been painstakingly done so far. With Sunbather, the transition to GMP can be done easily thanks to its recording features, interchangeable flow paths, and easily transferable design. Sunbather uses the same mixing process and protocols as the Sunscreen and Sunshine from the same Sun series, allowing for easy transition of adjusted formulation conditions to GMP. - Up to 1.8 L/h - Integrated inline dilution - Fully interchangeable flow paths - A wide variety of mixing devices - Software compliant with 21 CFR Part 11 - Process transferable from Sunshine

• Other Physics and Chemistry Equipment

Efficient mass production of LNPs - Supporting everything from small-scale condition testing to scale-up.

Once we succeed in finding the optimal formulation conditions for sunscreen, let's use Sunshine to adjust the size of the LNP. Furthermore, we will optimize the protocols and processes for scaling up. We will find the ideal flow rate and explore different mixing options. Next, we will adjust these to the appropriate dilution factor that can keep them stable. Once everything is in place, Sunshine will transition to continuous mode, allowing us to produce several dozen liters in a day. In other words, we will achieve process development and scaling up on a single platform. Many researchers have likely been looking forward to the birth of such a groundbreaking system. • 10 experiments in 15 minutes • Fraction & total flow • From 1 mL to continuous flow • Flow rate 0.1 to 30 mL/min • Reusable microfluidic chips • Possible transition of protocols from sunscreen

• Other Physics and Chemistry Equipment

Accelerating formulation optimization for vaccine and pharmaceutical development.

To create the optimal LNP, it takes a tremendous amount of time and effort to examine and pursue formulation conditions. LNPs are nanoparticles composed of multiple lipids. Therefore, it is necessary to find the optimal conditions such as the mixing ratios, the ratio of lipids to payload, and the flow rates during mixing. Furthermore, we must also consider throughput issues. Sunscreen can produce up to 96 types of small LNPs within six hours, thus solving the previous throughput problems. This means that it is possible to explore a greater number of formulation condition investigations in a single day. • Fully automated execution of up to 96 types of condition investigations within six hours • 200 μL to 2 mL per experiment • Flow rate of 0.1 to 30 mL/min • Reusable microfluidic chips • Seamless scale-up through process and protocol optimization

• Other Physics and Chemistry Equipment

We will be holding the second webinar on aluminum foil, which received great acclaim last time. This is an opportunity to deepen your knowledge about aluminum foil, so please join us. 【Webinar Details】 Content: Introduction to the Manufacturing Methods and Functional Aluminum Foils vol.2 Date: February 20 (Friday) Time: 15:00 - 16:00 Participation Fee: Free How to Participate: A Zoom viewing URL will be sent to those who register by the day before. Capacity: 100 people 【Recommended for the Following Individuals】 - Those who have challenges related to metal foils or resin films - Those interested in joint research with foil manufacturers or new business development - Those interested in functional aluminum foils with high smoothness, high corrosion resistance, high strength, and luxurious designs ▼ Register here (Microsoft Forms) https://forms.cloud.microsoft/r/UA5g4N2fGU (dummy) ▼ If you have any further questions, please contact us at the email address below. foil-marketing@toyal.co.jp

This exhibition is one of the largest specialized symposiums in Japan, focusing on fullerenes, carbon nanotubes (CNT), graphene, nanomaterials, advanced materials, functional materials, and two-dimensional materials. Many researchers and engineers involved in material development, device applications, measurement and analysis, research and development, and mass production technology will attend. At our booth, we will introduce products and technological solutions that support research in nanocarbon, advanced material evaluation, device development, and industrial applications from fundamental research. ■ Planned Exhibits - Products from PicoQuant - Ultra-high stability interferometer "GEMINI" (NIREOS) - Superconducting nanowire single-photon detector (SNSPD) (Single Quantum) - Broadband wavelength-tunable laser 400–1000nm SuperK CHROMATUNE (NKT Photonics)

We will be exhibiting at the 103rd Annual Meeting of the Physiological Society of Japan (PSJ2026). This academic conference is one of the leading specialized societies in Japan, gathering researchers and engineers who are active at the forefront of physiology, life sciences, and biomedical research. It is also recognized as a venue for showcasing and exchanging technologies related to biosensing devices, optical measurements, laser application equipment, advanced light sources, and high-precision evaluation techniques. At our booth, we will introduce products and solutions such as biosensing devices, laser light sources, high-stability laser systems, and advanced microscope light sources, supporting the advancement of medical measurement research and life sciences research. ■ Planned Exhibits - High-performance & high-stability CW laser LaserNest series for microscopes (Omicron Laserage Laserprodukte)

OPIE is one of Japan's largest specialized exhibitions related to optical technology, laser technology, and photonics, bringing together a wide range of technologies and products in fields such as optical instruments, laser systems, high-precision measurement devices, light source devices, optical components, imaging and sensor technology, and quantum innovation. This exhibition is attracting attention as a venue for showcasing and demonstrating the latest products and technologies in laser application technology, light source devices, optical measurement solutions, positioning systems, and advanced photonics devices, targeting industry professionals, research institutions, universities, development engineers, design engineers, and researchers. ■ Exhibited Content We will be exhibiting products and technologies primarily in the following fields and categories: - High-performance laser light sources / wavelength-tunable laser devices - Optical / beam profile measurement devices / beam analyzers - Light source and measurement peripherals / optical fiber fusion splicers - Nano-positioning stages / laser interferometric displacement sensors - Compact, high-precision laser processing devices / laser scanners - Non-contact thickness gauges / surface roughness gauges and other industrial measurement instruments - Super-resolution / optical microscope-related products (such as objective lenses, etc.)

Photonix [Osaka] is a specialized exhibition for optical technology, laser processing, photonics, and optical measurement instruments, showcasing the latest laser oscillators, precision processing equipment, optical components, and optical measurement solutions all in one place. This exhibition is a specialized event aimed at companies, research institutions, and development engineers seeking industrial laser processing, laser light sources, optical devices, precision measurement and analysis equipment, and photonics application technologies. ■ Planned Exhibits We will be showcasing the following laser, optical, and measurement equipment: - Pulse Fiber Laser "TruPulse nano" A high-performance pulse laser light source for industrial and precision processing. - Femtosecond Fiber Laser Indylit for fine processing Ultra-short pulse laser for fine and nano processing applications. - Simple Laser Cleaning Device Laser cleaning equipment effective for surface treatment and fine dirt removal. - 2-axis / 3-axis Galvano Scanner Scanning system for high-speed and high-precision laser beam control. Along with other products, we will broadly introduce laser processing, photonics, light sources, and optical measurement solutions.