[Free Webinar] Revolutionizing LNP Development: Smooth Technology Transfer for High-Speed and High-Precision Formulation Exploration and Manufacturing

Quality assessment of proteins, nucleic acids, AAV, LNP, etc. is possible with trace amounts and high throughput.

"Stunner" is a product that allows simultaneous acquisition of UV/Vis concentration, dynamic light scattering (DLS), and static light scattering (SLS) data from a 2μL identical sample. It enables detailed investigation of AAV and adenoviruses to measure total capsid titer and Empty/Full ratios, as well as to obtain payload concentration and size data of lipid nanoparticles all at once. You can analyze concentration, hydrodynamic size, polydispersity, and the presence of aggregates collectively, allowing you to assess the quality of proteins. This way, you can immediately determine whether your AAV, adenoviruses, lipid nanoparticles, or proteins are suitable for your purposes. [Features] ■ Measure up to 96 samples in a batch in 60 minutes*/12 minutes** *When measured by DLS **When measured by UV/Vis only [Applications] ■ AAV/Adenovirus capsid titer ■ AAV/Adenovirus Empty/Full ratio ■ Lipid nanoparticle (LNP) payload amount ■ Aggregate measurement ■ Concentration measurement ■ Sizing & polydispersity ■ B22 & kD *For more details, please refer to the PDF document or feel free to contact us.

• Other protein analysis

Introducing the details of the newly launched LNP production and screening device.

Researchers of lipid nanoparticles (LNPs) spend a tremendous amount of time on screening, optimization, and scaling up experiments to achieve optimal performance, spot-on targeting, and controlled release of active pharmaceutical ingredients (APIs). Factors such as solubility, pH stability, payload release, and encapsulation all depend on particle size, shape, and structure. In other words, to obtain the right formulation, it is necessary to explore a vast number of formulation parameters and process parameters one by one, and even if a perfect formulation is found, scaling up usually means switching equipment and re-optimizing settings. In this webinar, we will introduce a platform, Sunny Suite, that can reduce the time spent on these LNP formulations. ■ Date and Time: February 26 (Monday) 14:00~ ■ Speaker: Yuji Senoo, Field Application Scientist, Unchained Labs, Inc. ■ Register here: https://unchainedlabs.zoom.us/webinar/register/3217065146675/WN_U1o3xQoZRAKHN-A-7b1yqg

• Other protein analysis

Seamlessly transition from formulation condition screening to scale-up and GMP manufacturing. Accelerate LNP product development.

The development of lipid nanoparticles (LNPs) faces many challenges. The formulation, optimization, and scale-up for clinical trials are complex, costly, and a race against time. Our LNP solutions are designed to accelerate all steps of LNP synthesis and characterization. Sunscreen accelerates LNP formulation screening by reducing costs and time, generating up to 96 unique LNP formulations within 6 hours. Next, using Sunshine, you can develop, optimize, and scale up protocols with the appropriate formulations obtained from Sunscreen. When it comes to the clinical trial phase, Sunbather can accommodate LNP production in a GMP environment using the same processes and microfluidic chips (Sunny) utilized by Sunscreen and Sunshine. In this way, the Sun series allows for a seamless transition from screening formulation conditions to scale-up and GMP manufacturing, as they all use the same pumps and microchannel chips. *For product details, please download various materials.

• Other Physics and Chemistry Equipment

Accelerating formulation optimization for vaccine and pharmaceutical development.

The transition from LNP to GMP is a costly and complicated process. Typically, this requires switching equipment, using different flow paths and mixing devices, and essentially re-developing and re-validating everything that has been painstakingly done so far. With Sunbather, the transition to GMP can be done easily thanks to its recording features, interchangeable flow paths, and easily transferable design. Sunbather uses the same mixing process and protocols as the Sunscreen and Sunshine from the same Sun series, allowing for easy transition of adjusted formulation conditions to GMP. - Up to 1.8 L/h - Integrated inline dilution - Fully interchangeable flow paths - A wide variety of mixing devices - Software compliant with 21 CFR Part 11 - Process transferable from Sunshine

• Other Physics and Chemistry Equipment

Efficient mass production of LNPs - Supporting everything from small-scale condition testing to scale-up.

Once we succeed in finding the optimal formulation conditions for sunscreen, let's use Sunshine to adjust the size of the LNP. Furthermore, we will optimize the protocols and processes for scaling up. We will find the ideal flow rate and explore different mixing options. Next, we will adjust these to the appropriate dilution factor that can keep them stable. Once everything is in place, Sunshine will transition to continuous mode, allowing us to produce several dozen liters in a day. In other words, we will achieve process development and scaling up on a single platform. Many researchers have likely been looking forward to the birth of such a groundbreaking system. • 10 experiments in 15 minutes • Fraction & total flow • From 1 mL to continuous flow • Flow rate 0.1 to 30 mL/min • Reusable microfluidic chips • Possible transition of protocols from sunscreen

• Other Physics and Chemistry Equipment

Accelerating formulation optimization for vaccine and pharmaceutical development.

To create the optimal LNP, it takes a tremendous amount of time and effort to examine and pursue formulation conditions. LNPs are nanoparticles composed of multiple lipids. Therefore, it is necessary to find the optimal conditions such as the mixing ratios, the ratio of lipids to payload, and the flow rates during mixing. Furthermore, we must also consider throughput issues. Sunscreen can produce up to 96 types of small LNPs within six hours, thus solving the previous throughput problems. This means that it is possible to explore a greater number of formulation condition investigations in a single day. • Fully automated execution of up to 96 types of condition investigations within six hours • 200 μL to 2 mL per experiment • Flow rate of 0.1 to 30 mL/min • Reusable microfluidic chips • Seamless scale-up through process and protocol optimization

• Other Physics and Chemistry Equipment

At Eihon Seiki, we handle Brookfield's rotational viscometers, which are widely used by many customers. We offer consulting services such as measurement method proposals and data analysis to assist our customers with viscometers and rheometers. As part of our ongoing commitment to customer service, we have planned a viscometer user seminar. We will invite Professor Toshiyuki Shikata, an emeritus professor at Tokyo University of Agriculture and Technology, who is active in the field of rheology, to give a lecture covering the basics of viscosity and an introduction to viscoelasticity. There will also be opportunities to ask questions to Professor Shikata and our technical staff regarding any issues or uncertainties you may have in your daily work. We encourage you to consider participating in this opportunity. Seminar Overview: - We will provide an easy-to-understand lecture on the basics of viscosity and viscosity measurement. - We will explain points that can help improve the reproducibility of daily measurements and maintenance within your company. - We will introduce the dispersion of solutions and stability evaluation through live demonstrations. - You will have the opportunity to ask questions directly to Professor Shikata and Eihon Seiki's technical staff.

[Key Lecture Content] 1. The current status of geothermal heat in our country and the Ministry of the Environment's initiatives for its promotion Ministry of the Environment, Water and Air Quality Bureau, Environmental Management Division, Environmental Pollution Control Office Assistant Director Matsui Tatsu 1. About geothermal heat 2. About groundwater heat 3. Utilization for energy conservation 4. Utilization for decarbonization 5. Q&A / Business card exchange 2. Technological trends of geothermal heat pumps and advanced examples from Japan and abroad Non-profit organization Geothermal Utilization Promotion Association Chairman Sasada Masakatsu 1. Overview of geothermal heat pumps and their energy-saving and environmental properties 2. Trends in closed-loop technology 3. Trends in open-loop technology 4. Technological trends of air conditioning systems using geothermal heat as a heat source 5. Future prospects for geothermal heat pumps 6. Q&A / Business card exchange

[Speaker] Cabinet Office, Government of Japan Science and Technology Innovation Promotion Office Planning Officer Takayuki Sato [Key Lecture Content] Japan's AI policy is structured around the fundamental directions of "balancing innovation promotion and risk response" and "international cooperation." In the AI Basic Plan established at the end of last year, we aim to pursue "trustworthy AI" that maintains a human-centered AI society where individual dignity is respected, enabling continuous collaboration between humans and AI. Our goal is to make Japan "the easiest country in the world to develop and utilize AI." This lecture will provide an overview of Japan's AI policies, including examples of initiatives. [Lecture Items] 1. Evolution and development trends of AI 2. Japan's AI policy (background of the AI law enactment, promotion system, etc.) 3. AI-related initiatives (AI Basic Plan, AI guidelines, etc.) 4. Q&A / Business card exchange

In this 5S seminar, we won't just stop at "organizing and tidying up." We will provide plenty of tips on how to utilize 5S as a "visualization of work" and a "tool for discovering waste," evolving the workplace into a more comfortable and productive environment! ✅ Improvement tips you can use starting tomorrow ✅ Engaging and practical exercises and workshops that will inspire and excite you From "doing it because I was told to" to "wanting to take action myself" Your step forward will lead to the evolution of the entire team. This is an opportunity to cultivate a "mindset for improvement" among young employees and enhance the autonomy of the entire organization. From "waiting for instructions" to "thinking and taking action" As you become more accustomed to your work, you will notice the waste and potential that exists. Now, let's gain the "power to change" with 5S! Benefits of 5S: 1. People grow 2. Time becomes more abundant 3. The workplace environment improves 4. 5S does not require significant costs 5. It can be implemented regardless of company size or job type 6. It is appreciated by stakeholders We will teach you the tips to transform 5S from something done because a superior said to do it, or only when there is time, into an enjoyable and sustainable practice. *For more details, please download the PDF or contact us.

This exhibition is one of the largest specialized symposiums in Japan, focusing on fullerenes, carbon nanotubes (CNT), graphene, nanomaterials, advanced materials, functional materials, and two-dimensional materials. Many researchers and engineers involved in material development, device applications, measurement and analysis, research and development, and mass production technology will attend. At our booth, we will introduce products and technological solutions that support research in nanocarbon, advanced material evaluation, device development, and industrial applications from fundamental research. ■ Planned Exhibits - Products from PicoQuant - Ultra-high stability interferometer "GEMINI" (NIREOS) - Superconducting nanowire single-photon detector (SNSPD) (Single Quantum) - Broadband wavelength-tunable laser 400–1000nm SuperK CHROMATUNE (NKT Photonics)