Cysteine protease 'FabRICATOR (IdeS)'

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last updated：Apr 10, 2026

重松貿易大阪本社

Cutting just below the IgG hinge region! Widely used for production monitoring and clone selection!

"FabRICATOR(IdeS)" is an IgG-specific cysteine protease that digests antibodies at a single amino acid site just below the hinge region. It is capable of generating homogeneous F(ab')2 and Fc fragments. This enzyme is widely used for the characterization, quality control, stability testing, production monitoring, and clone selection of antibody-based therapeutics such as mAbs, ADCs (antibody-drug conjugates), biosimilars, and Fc fusion proteins. 【Features】 ■ Digests antibodies at a single amino acid site just below the hinge region ■ Capable of generating homogeneous F(ab')2 and Fc fragments ■ Pre-treatment for LC-MS analysis workflow at an intermediate level - Reduces subunits to generate fragments of 23–25 kDa - Enhances mass resolution to accurately determine important quality attributes *For more details, please refer to the PDF document or feel free to contact us.

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basic information

【Product Format】 ■FabRICATOR: Freeze-dried enzyme product ■FragIT: Product with enzyme fixed on a spin column ■FragIT kit: Set of FragIT and CaptureSelect (Fc fragment purification column) ■FabRICATOR-HPLC: Product with enzyme fixed on a column that can be connected to HPLC ■FabRICATOR MagIC: Product with enzyme fixed on magnetic beads ■FabRICATOR Validation kit: Set of freeze-dried products from three different batches *For more details, please refer to the PDF materials or feel free to contact us.