α-N-acetylgalactosaminidase "GalNAcEXO"

Hydrolysis of α-linked GalNAc! Introducing a valuable tool to reduce sample heterogeneity!

The enzyme 'GalNAcEXO' is an α-N-acetylgalactosaminidase that efficiently hydrolyzes terminal GalNAc on glycoproteins. GalNAc, which is bound to serine or threonine and referred to as the Tn antigen, is rapidly and efficiently hydrolyzed by GalNAcEXO, and it also shows activity against α1-3 linked GalNAc. This enzyme serves as a valuable tool in the analysis of complex O-glycosylated proteins that have α-linked GalNAc as a core 1 with a sugar chain that has stopped elongating, reducing sample heterogeneity. 【Features】 ■ Hydrolyzes GalNAc on glycoproteins under native conditions ■ Shows activity in the pH range of 6.0 to 7.6 ■ No cofactors or special buffers are required ■ Reactions on glycoproteins are completed in 2 hours (depending on the nature of the substrate) ■ Complex samples may require overnight incubation *For more details, please refer to the PDF document or feel free to contact us.

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