The success rate over the past three years boasts over 90% and has been adopted by many pharmaceutical companies.
The custom monoclonal antibody production service "Antibody Craftsman" provided by Gene Frontier utilizes a unique antibody production technology (human Fab antibody library and phage display) that does not rely on animals, allowing for the creation of antibodies that can recognize the presence or absence of post-translational modifications and differences in amino acids, which is a significant feature. The HuCAL technology, which uses the human Fab antibody library and phage display, has over 10 years of proven results worldwide, having produced 14,000 antibodies. In the past three years, the success rate has boasted over 90%, and it has been adopted by many pharmaceutical companies and others. For example, we can produce antibodies such as: ■ Antibodies that identify post-translational modifications ■ Antibodies that specifically recognize homologous regions ■ Antibodies that identify substitutions or deletions of a few amino acids ■ Antibodies that recognize denatured proteins If you consult us about the specificity and usage of the desired antibody, we will propose a planning strategy for antibody production, including antigen design, selection methods tailored to the type and application of the antigen, and choices regarding the format and tags of the antibody. *For more details, please refer to the PDF materials or feel free to contact us.
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basic information
▼First, Planning▼ The "Antibody Craftsman" monoclonal antibody production service begins with antibody planning as the first step when we receive inquiries about antibody production from customers. To create antibodies suitable for the customer's intended use, we will ask about the characteristics of the antigen and the purpose of the antibody. Next, we will design the antigen according to the purpose of the antibody to be obtained, and experienced staff will propose strategic selection methods tailored to the type of antigen and the intended use of the antibody throughout the entire process. ▼Format and Reproduction of Delivered Antibodies▼ The antibodies produced will be in the form of Fab, and you can choose between monovalent or divalent options, as well as two types of tags, to be delivered in your desired format. The obtained antibodies will be purified as recombinant proteins from E. coli, allowing us to deliver them with the same quality repeatedly. Additionally, it is also easy to convert Fab into immunoglobulin isotypes such as IgA, IgE, IgG, and IgM.
Price range
Delivery Time
※At the shortest, 7 weeks from the receipt of the antigen.
Applications/Examples of results
Antibodies produced by "Antibody Craftsman" can be used in various applications just like antibodies produced by conventional methods. Furthermore, since they are Fab antibodies, they possess properties that can provide additional advantages in certain assay systems, such as not needing to remove the Fc region to prevent binding to receptors or to minimize the reaction of human anti-mouse antibodies (HAMA). Additionally, tag-specific detection antibodies are very useful in many applications.
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Company information
Gene Frontier has been expanding its business areas that contribute to the acceleration of biopharmaceuticals, including antibody drugs, and has been advancing the development of its unique technologies. Moving forward, we aim to accelerate our research and development and business development to achieve further growth on a global scale. We will continue to provide unique technologies and services for the development of innovative pharmaceuticals and diagnostic drugs, striving to be a trusted partner for our customers and contribute to 21st-century healthcare.
