It can be used for the evaluation of preventive and therapeutic components for hepatic steatosis!
"PXB-cells LA" are human fatty liver cells optimized for lipid analysis, derived from fresh human liver cells (PXB-cells) collected through collagenase perfusion from human liver chimeric mice (PXB mice) using a special culture method. It has been confirmed that they can maintain the same lipid metabolic functions as fresh human liver cells at a high level for up to 10 days after delivery. Additionally, it is possible to maintain the secretion of human albumin, drug metabolism enzymes, and transporter activity for an extended period under culture conditions. 【Features】 ■ Maintains the same lipid metabolic functions as fresh human liver cells at a high level for up to 10 days after delivery ■ Forms large lipid droplets similar to the tissue morphology of human fatty liver within hepatocytes ■ Confirms the secretion of large VLDL (Large-VLDL) with a large particle size ■ Provides high-quality fresh human liver cells from the same donor at a low and stable supply ■ Confirms that similar responses to clinical trials can be obtained with anti-lipid drugs *For more details, please refer to the PDF document or feel free to contact us.
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basic information
【Flow from Order to Delivery】 ■ Request for PXB-cells LA (Order) ■ Order Confirmation Contact ■ Preparation and Seeding ■ Shipment ■ Arrival (Delivery) ■ Mailing of Invoice, etc. *For more details, please refer to the PDF document or feel free to contact us.
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【Usage】 ■ Can be used as human fatty liver model or human normal liver model hepatocytes depending on the number of culture days after delivery. * For more details, please refer to the PDF document or feel free to contact us.
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Company information
Our company offers contract testing services for drug development using PXB mice, which are high-quality human liver cell chimeric mice, as well as PXB mouse-related products. We have developed a technology that focuses on the function and proliferation ability of human liver cells, allowing them to proliferate in large quantities within experimental animals while maintaining their functionality. We are expanding a new business that provides the functions of human liver cells in a way that is easy to utilize for various applications.