Technical Information Magazine 201911-01 Biomaterials in the Field of Regenerative Medicine

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Technical Information Magazine The TRC News "Evaluation of Biomaterials in the Field of Regenerative Medicine - Properties of Alginate Scaffold Materials and Gelation Mechanisms -" [Abstract] Biomaterials in the field of regenerative medicine require material design aimed at enhancing cell function. The details of which properties contribute to cell function remain an unresolved issue, but mechanical and morphological characteristics are attracting attention. This paper presents examples of property evaluation focusing on alginate gels. Furthermore, elucidating the gelation mechanism is crucial for property control, and a proposal for the gelation mechanism was made through the analysis of the gelation process from alginate aqueous solutions. [Table of Contents] 1. Introduction 2. Property Evaluation of Alginate Gels 3. Gelation Mechanism of Alginate 4. Conclusion [Figures and Tables] Figure 1 - Figure 11 Frequency dependence of storage modulus and loss modulus of M- and G-rich gels Dependence of M/G ratio on storage modulus and loss modulus at 1 Hz Microscopic observation images of dielectric constant of M- and G-rich aqueous solutions and gels Viscoelastic changes during the gelation process Changes in SAXS during the gelation process, changes in 1H pNMR curves Changes in crosslink point size and molecular mobility during the gelation process of M- and G-rich alginates

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