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  6. Cosmetic ingredients for dry and dehydrated skin, microbiome adjustment, holobiosis.

Cosmetic ingredients for dry and dehydrated skin, microbiome adjustment, holobiosis.

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last updated:Nov 06, 2025

HIGUCHI INC.
HIGUCHI INC.
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An extract fermented with cold-resistant bacteria from the roots of gentian collected in the French Alps, designed for dry and dehydrated skin with microbiome-regulating ingredients.

This product is an extract fermented with rare cold-resistant bacteria that inhabit the air in France, using the roots of wild gentian organically grown in the high mountains of France. This bacteria is resistant to cold and dry environments, and the holobiosis fermented with it demonstrates effectiveness for dehydrated (water-deficient) and dry (lipid-deficient) skin, showing various efficacy data such as promoting hyaluronic acid synthesis in the epidermis and dermis, antioxidant effects, strengthening barrier functions, and promoting beneficial skin bacteria. Main components: polar lipids, amino acids, loganin acid, swertia amarin. Standardized. In Vitro: Hyaluronic acid synthesis: +62% (keratinocytes), +32% (fibroblasts) CD44 synthesis: +42% (keratinocytes) Lipid synthesis: +147% (keratinocytes) Increase in tight junction-related proteins Increase in basement membrane structural proteins (2 types) Increase in collagen-binding proteins (2 types) Increased expression of antioxidant-related genes (8 types) In Vivo: Skin surface moisture content: +7.3% (all subjects), +12.5% (seborrheic deficiency) Promotion of sebum production: +27% (all), +43% (deficiency) Wrinkle length: -5% Epidermal Staphylococcus: +39% Ralstonia species: +45%

    Cosmetic materials and raw materialsOther pharmaceutical intermediates and cosmetic ingredientsOther medical supplies and cosmetic manufacturing materials
ホロビオシス 表紙_page-0001.jpg

Cosmetic ingredients for dry and dehydrated skin, microbiome adjustment, holobiosis.

ホロビオシス 表紙_page-0001.jpg
ホロビオシス 表紙_page-0001.jpg
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Green Tech Co., Ltd. is a company established in 1992. The company has been importing and selling various types of plant extracts in Japan for about 20 years, and we have heard that Japanese customers perceive Green Tech as a manufacturer of plant extracts with a wide range of products. In fact, the company handles over 5,000 types of plant extracts. In addition to traditional plant extracts, we also produce and sell products that focus on the biodiversity of South America and the Amazon, including plant extracts and oils, as well as products developed based on microbial research that demonstrate effectiveness in maintaining microbial community homeostasis. We also manufacture and sell products derived from algae and microalgae, including components and extracted extracts. In recent years, we have been focusing on research and development, enhancing evaluation data for our products in both In-Vivo and In-Vitro studies, as well as conducting research and development in response to new trends such as skin microbiomes. Additionally, we are committed to the development and manufacturing of products that have demonstrated effectiveness by increasing the concentration of active ingredients using our proprietary freeze technology (preservation, grinding, extraction) and fermentation technology. These manufacturing technologies are not only used for the development of our own products but also support the development of customized products.

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Recommended blending amount: 1% Dry skin care products Moisturizing care products Skin holobiont active products

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Cosmetic ingredients for dry and dehydrated skin, microbiome balancing ingredient, Holobiosis.

Cosmetic ingredients for dry and dehydrated skin, microbiome balancing ingredient, Holobiosis.

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HIGUCHI

HIGUCHI INC.

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Starting as an import trading company in 1927, we have been developing our business with many overseas suppliers and domestic customers over the years. Through our services of connecting the two together, Higuchi has become the well trusted "Japan distribution channel" for suppliers, and the "dependable vendor" who provides a stable supply of the latest high-valued overseas products to customers. Today, we conduct not only importing but also exporting businesses, trilateral trades, and overseas business investments as well. We have also expanded to local subsidiaries in the United States and China, to which we are able to effectively network overseas. Higuchi believes in the criticalness of providing a stable supply to customers, and we also place the highest priority on the coexistence with suppliers, to whom we can mutually develop together in a long-term perspective. Your support and consideration to our corporate philosophy would be much appreciated.

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