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  6. Cosmetic ingredients, clock gene regulation, happiness hormone promotion, stress care extract.

Cosmetic ingredients, clock gene regulation, happiness hormone promotion, stress care extract.

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last updated:Feb 16, 2026

HIGUCHI INC.
HIGUCHI INC.
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Sarkalis adjusts the internal clock, improves autophagy, promotes the production of melatonin, antioxidant enzymes, and happiness hormones, and provides stress care.

As society's development accelerates, our bodies are constantly confronted with various environments and stressors to which we have not adapted (e.g., night shifts, social obligations, lack of sleep). Furthermore, this stress disrupts the body's natural rhythms (circadian rhythms). This product promotes improvements in autophagy, melatonin production, antioxidant enzyme production, and stimulation of anti-aging genes by regulating the body clock-related genes (CLOCK, CRY1, PER), addressing tired appearance and stress care. = in Vitro ex Vivo = Regulation of CLOCK, CRY1, PER (adjustment of circadian rhythms) Autophagy LC3(2): +93% Cell stress P53: -20% Melatonin receptor MT1: +24% NFR-2: +85% SIRTUIN1: +56% - Promotion of happiness hormones Oxytocin: +82% Endorphin receptor: +20% Endocannabinoid receptor: +21% = in Vivo = - Improvement of tired appearance Dark circles: -13% Eye bags: -28% Fine wrinkles: -21% Dullness - Yoga-like effects on mood Sense of happiness: +8% Negative emotions: -17%

    Cosmetic materials and raw materialsOther pharmaceutical intermediates and cosmetic ingredientsOther medical supplies and cosmetic manufacturing materials
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Cosmetic ingredients, clock gene regulation, happiness hormone promotion, stress care extract.

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Greentech is a pioneering company in plant biotechnology, established in 1992 in Clermont-Ferrand, France. The company is characterized not only by its excellent manufacturing technologies such as extraction, fermentation, and freezing, but also by its capabilities in exploring and analyzing active ingredients using molecular modeling, bioinformatics, transcriptomics, and ethnobotany, as well as its evaluation techniques for these active ingredients. The company investigates various regions and environments around the world, collecting organisms such as plants, algae, and microorganisms that inhabit those areas, and develops innovative products for cosmetics, pharmaceuticals, and functional foods by utilizing the active substances derived from their biological mechanisms. The spirit of sustainability, consistent since its founding, is reflected in the range of products developed and manufactured. To date, the company has provided over 5,000 types of plant extracts and more than 100 products born from innovative ideas, all backed by abundant efficacy data, to customers around the world.

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Recommended blending amount: 1-5% Uses: - Femcare products - Stress care products - Tired face care products

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Cosmetic ingredients, clock gene regulation, promotion of happiness hormone production, stress care extract, Circalis.

Cosmetic ingredients, clock gene regulation, promotion of happiness hormone production, stress care extract, Circalis.

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HIGUCHI

HIGUCHI INC.

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Starting as an import trading company in 1927, we have been developing our business with many overseas suppliers and domestic customers over the years. Through our services of connecting the two together, Higuchi has become the well trusted "Japan distribution channel" for suppliers, and the "dependable vendor" who provides a stable supply of the latest high-valued overseas products to customers. Today, we conduct not only importing but also exporting businesses, trilateral trades, and overseas business investments as well. We have also expanded to local subsidiaries in the United States and China, to which we are able to effectively network overseas. Higuchi believes in the criticalness of providing a stable supply to customers, and we also place the highest priority on the coexistence with suppliers, to whom we can mutually develop together in a long-term perspective. Your support and consideration to our corporate philosophy would be much appreciated.

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