Design of crRNA for CRISPR-Cas3 genome editing and service for the production of crRNA and Cas protein complexes.
This service provides the design of crRNA (guide RNA) for CRISPR-Cas3 genome editing and the production of a complex of crRNA and Cas proteins (Cas complex for antiviral defense, Cascade-crRNA complex). We co-express five types of proteins that make up the Cascade and one type of crRNA, and deliver the purified Cascade-crRNA complex. Additionally, the proteins that constitute the Cascade (Cas11, Cas7, Cas6) have nuclear localization signals (NLS). By combining the Cascade-crRNA complex produced by this service with the separately sold Cas3 protein NLS that has cleavage activity, it can be utilized in the new genome editing technology "CRISPR-Cas3 system" developed in Japan. *For more details, please refer to the catalog.
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basic information
【Concentration】: 25 μg/μL Cascade-crRNA complex 【Deliverables】: - Cascade-crRNA complex: 10 µL x 1 tube or more depending on yield (*1) - Substrate plasmid: 1 tube - Inspection report (PDF) 【Storage temperature】: -80℃ (*1) We will aliquot 250 µg (10 μL) into tubes and ship only the amount produced. As a guideline, we expect to provide approximately 6 to 15 tubes per sequence, but this is not guaranteed.
Price range
Delivery Time
※3-4 months
Applications/Examples of results
For more details, please refer to the catalog or feel free to contact us.
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Company information
Our company is a product development-oriented enterprise that utilizes biotechnology. We develop and manufacture in vitro diagnostic pharmaceuticals (such as pregnancy tests and ovulation tests), diagnostic drugs for environmental, food, and animal and plant diseases, and reagents for genetic engineering research, using our expertise in gene and antibody technology. We hold manufacturing registration and manufacturing and sales licenses for both human and animal products, with over 30 years of experience in the manufacture of in vitro diagnostic pharmaceuticals. Additionally, we are engaged in personalized medicine, advancing research and development of diagnostic drugs using genetic polymorphism analysis and gene expression analysis.