[Case Study of Membrane Permeability Measurement System] Evaluation of Membrane Permeability Using μFLUX
Explaining the effect of pH modifiers on the membrane permeability of diclofenac!
We would like to introduce a case study on the application of the membrane permeability measurement system "μFLUX." In our previous research, we developed a sustained-release formulation containing an alkalizer, and we attempted to apply this device to evaluate its usefulness in reducing gastric mucosal damage caused by DC. In this study, we only simulated the pH environment, but incorporating other components such as lipids and proteins is expected to lead to a more accurate evaluation. 【Case Overview】 ■ Study - Evaluated the impact of pH fluctuations in the microenvironment caused by the alkalizer on the membrane permeability of the acidic drug DC using μFLUX. ■ Results - It was demonstrated that μFLUX could be a useful tool not only for evaluating drug absorption but also for assessing the risk of side effects caused by drug accumulation in tissues. *For more details, please download the PDF or feel free to contact us.
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Physio-Machina Co., Ltd. is a company that primarily sells products such as formulation development equipment and dissolution testers, conducts validation and calibration of peripheral devices, and engages in the import and export of software and various equipment. Additionally, it actively provides translation and interpretation of technical documents and seminars, as well as support for the creation of SOPs and conducts training sessions.