Cationic lipids for LNP formulations
■Efficiency: By adjusting the characteristics of LNP with the library, optimization of in vivo distribution according to therapeutic purposes is achieved. ■Safety: The unique imidazolium structure is protected by a proprietary patent held by Sartorius Polyplus. ■Validated: Concept proof tests (PoC) have been successfully conducted in both in vitro and in vivo settings. ■Flexibility: A highly versatile library that allows for the selection of LipidBrick lipids optimal for each application.
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basic information
LipidBrick is a library composed of cationic lipids with a unique and innovative imidazole structure, which can be utilized for the formulation of lipid nanoparticles (LNPs). These lipids protect mRNA molecules and enhance the transfection efficiency of LNPs. Cationic lipids are constantly charged, and unlike ionizable lipids, the entire structure of LNPs is positively charged, making it easier to deliver to tissues other than the liver. Furthermore, by screening the LipidBrick library, you can select the optimal cationic lipids for specific applications and therapeutic needs, achieving adjustments in delivery efficiency and in vivo distribution.
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Company information
Sartorius Stedim, established in 2007 through the merger of the German company Sartorius, founded in 1870, and the French company Stedim, is a pioneer in "Single-Use Technology (SUT)." As a company capable of providing comprehensive technical support to the pharmaceutical and biotechnology industries, its cutting-edge technology is highly regarded worldwide in the fields of scientific instruments and biotechnology.