Single-cell spatial multi-omics
COMET, which fully automates in situ hybridization and immunostaining along with imaging, clearly captures intercellular interactions and local changes, bringing about a revolution in a wide range of fields from basic research to translational research in understanding pathologies such as cancer, neurological diseases, and infectious diseases, paving the way for new diagnostic and therapeutic development.
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basic information
<Number of Simultaneous Staining Items> - 40 items/Run (the number of items is virtually unlimited) - Proteomics application: 40-plex (one automated run) - Multi-omics application: 12 RNA + 24 protein targets or 4 RNA + 28 protein targets Number of simultaneous staining slides: 4 Maximum image acquisition area: 12.5×12.5mm Staining area: 21×21mm Throughput: 20 slides/week (20-plex), 12 slides/week (40-plex) (when acquiring 9×9mm) Detection channels: DAPI, FITC, TRITC, Cy5, Cy7 Main unit size: W1,105 x D 635 x H 535 mm Weight: 105kg Power supply: 100–240VAC 50/60Hz
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Applications/Examples of results
- Complete automation of the entire process, including seqIF staining, image acquisition, and preprocessing, from one molecule detectable RNAscope HiPlex Pro (ISH) with a single click. - Unlimited use of all primary antibodies without the need for labeling. - High throughput with a maximum of 4 slides per run and up to 20 slides per week. - Efficient removal of antibodies while maintaining sample morphology and epitope integrity. - Reusable for downstream analyses such as H&E staining and IHC. - High reproducibility through automation and microfluidics.
Detailed information
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Uniform supply of reagents using high-speed liquid exchange technology Achieving efficient antibody reactions in 2-4 minutes
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Company information
Protein Simple Japan Co., Ltd. is a member of a division based on Bio-Techne's protein-related products. We provide a wide range of tools, from immunoassay systems that quantify protein expression to systems that elucidate the structure and purity of protein-based pharmaceuticals. Please feel free to contact us if you have any inquiries. Contact email address: info.japan@proteinsimple.com X (formerly Twitter): https://x.com/ProteinSimpleJ
