CF Box | Aseptic Filling and Automation System for Regenerative Medicine and Cell Therapy

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CF Box

last updated：Oct 03, 2025

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CF Box | Aseptic Filling and Automation System for Regenerative Medicine and Cell Therapy

An innovative solution to achieve the manufacturing process of cell and gene therapy (ATMP) without clean rooms, through automation and cost reduction.

Related Link - https://www.pbl.it/wp-content/uploads/2024/05/PBL-…

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basic information

The CF box is an automated system that integrates aseptic filling, culture, separation, and storage required in the manufacturing of regenerative medicine and cell therapy. Compared to conventional cleanroom-dependent processes, it offers low cost, high efficiency, and high safety. Aseptic Filling / Liquid Transfer (supports 10µL to 50L) Flexibly accommodates processes such as cell separation, expansion culture, and virus introduction. Integrates incubators and refrigerators to reduce the risk of cross-contamination. High-precision filling and inspection using AI image recognition and load cells. Lower initial investment and running costs than cleanrooms.

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Applications/Examples of results

■Recommended for the following customers: - Regenerative medicine CPC (Cell Processing Facility) - Research institutions and CDMOs dealing with cell and gene therapies (such as CAR-T and iPS-derived cell therapies) - Pharmaceutical companies considering automation and scale-up at low cost ■Benefits of introduction: - No need for expensive Grade A/B clean rooms (can operate with Grade D) - Automation of operator-dependent tasks → Standardization of processes - Ability to process multiple treatments and batches in parallel - Return on investment (ROI) can be evaluated in advance (feasibility study support)