Low-Endotoxin Sodium Hyaluronate
Pharma Grade / High Purity Low Endotoxin Sodium Hyaluronate Bio-Fermented Medical and Cosmetic Ingredients
High purity grade with endotoxin levels below 0.05 EU/mg. Premium HA with safety and stability suitable for ophthalmic surgery, eye drops, and high-performance cosmetics.
Low-Endotoxin Sodium Hyaluronate is a high-purity sodium hyaluronate raw material for medical and cosmetic use, from which endotoxins have been highly removed. Endotoxins are dangerous pyrogenic substances that can cause fever, circulatory disorders, endotoxin shock, and DIC (disseminated intravascular coagulation), and therefore require extremely strict management in eye drops and ophthalmic surgical aids. Our company has successfully controlled the endotoxin content to below 0.05 EU/mg, which is the pharmaceutical grade standard, by renewing the manufacturing process and introducing precise ultrafiltration and adsorption technologies. This product possesses high lubricity and excellent moisture retention, providing various functions such as corneal protection, physical support for ocular tissues, and promotion of wound healing. In the field of ophthalmology, it is highly regarded as an auxiliary agent during cataract surgery, lens transplantation, corneal transplantation, and glaucoma surgery. Additionally, it has properties that promote wound healing and is widely used in clinical and medical fields. Our low-endotoxin HA is consistently manufactured in a factory certified with ISO9001, HACCP, and GMP, and is provided under high-level quality management in compliance with the ISO14001 environmental management system.
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basic information
INCI Name: Sodium Hyaluronate Quality Grade: Low Endotoxin (Pharma Grade) Endotoxin Level: ≤0.05EU/mg (Eye Drop Standards) Appearance: White to off-white powder / Transparent high-viscosity solution Purity: ≥98% (HPLC) Molecular Weight Range: 100,000 to 2,000,000 Da (Customizable for different applications) Protein Residue: Extremely low levels, compliant with medical application standards Solubility: Rapidly dissolves in water, forming a transparent solution pH: 6.0 to 7.5 Stability: Designed for high stability against heat and shear Characteristics: Strong moisture retention, lubricating properties, tissue protection Manufacturing Method: Precision bio-fermentation + advanced ultra-filtration purification Storage Conditions: Light-protected, dry, and low-temperature storage Certifications: ISO9001 / HACCP / GMP / ISO14001 Testing: Full lot testing for microorganisms, metals, impurities, protein quantification, etc.
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Applications/Examples of results
This is a high-purity sodium hyaluronate raw material widely used in both the medical and cosmetic fields. In medical applications, it is used as an auxiliary agent in ophthalmic surgeries such as intraocular lens insertion during cataract surgery, corneal transplants, and glaucoma surgeries, contributing to corneal protection, intraocular pressure stabilization, and smooth tissue separation. Additionally, due to its characteristic of having an endotoxin level of 0.05 EU/mg or lower, it is suitable for formulations that require high safety, such as eye drops, ophthalmic gels, and joint injection agents. In the cosmetic field, it is used in precision skincare, products for sensitive skin, high-function moisturizing serums, and wound care cosmetics, providing high added value through long-lasting hydration, barrier support, and skin roughness care. This product has a proven track record of adoption by domestic and international medical device manufacturers, ophthalmic formulation manufacturers, cosmetic OEM companies, wound care brands, and research institutions, and is highly regarded as a reliable raw material in both pharmaceuticals and cosmetics.
Company information
YOUCHANG INDUSTRIAL DEVELOPMENT CO., LTD is a specialized manufacturer of natural ingredients, focusing on herbal extracts and plant-derived extracts, and is a global company with strengths in international exports. We develop products that integrate traditional knowledge of Chinese medicine with biotechnology, catering to diverse industries such as pharmaceuticals, cosmetics, health foods, functional beverages, personal care, animal nutrition, and aromatherapy. Our main products include herbal extracts, fruit and vegetable powders, tea extracts, peptides, active pharmaceutical ingredients (APIs), natural flavors, essential oils, reed diffusers, and aroma candles. We utilize advanced extraction technologies such as supercritical CO₂ extraction, low-temperature vacuum concentration, membrane separation, and spray drying to achieve high purity and stability of components. We have obtained various international certifications including ISO, GMP, HACCP, HALAL, KOSHER, and organic certification, establishing a quality control and traceability system. We can accommodate both small batches and large-scale production. Through stable quality, competitive pricing, professional support, and sustainable sourcing of raw materials, we build trust with business partners around the world.
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