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  6. Synthesis technology of E-alkenes using new aluminum-based complexes [Saitama University]

Synthesis technology of E-alkenes using new aluminum-based complexes [Saitama University]

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last updated:Jun 24, 2026

信州TLO
信州TLO
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Synthesize E-type alkenes with high efficiency!

This technology is a method for synthesizing E-type alkenes in high yield through the selective reduction of alkynes. In conventional methods, the synthesis of E-type alkenes from alkynes had low yield and selectivity, making efficient synthesis difficult. This technology has achieved high-efficiency synthesis of E-type alkenes by developing a novel aluminum-based complex. It is a versatile and low-cost synthesis method that does not require hazardous reagents, gases, or expensive transition metals. Features of the technology: - High yield and high selectivity for synthesizing E-type alkenes from internal and terminal alkynes. - Diverse alkene derivatives can be developed starting from the synthesized substituted alkenes. - No need for safety-considerate equipment or facilities; reactions can be conducted using conventional equipment. *For more details, please download the PDF or feel free to contact us.*

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Synthesis technology of E-alkenes using new aluminum-based complexes [Saitama University]

  • Related Link - https://shinshu-tlo.co.jp/technology/k001-0046/

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(Technical Content) New Hydroalumination Reaction Using a Novel Aluminum Catalyst ■ Using a complex of fluoride salts and di-substituted hydride aluminum ■ Synthesis of substituted alkenes  ・ For internal alkynes, high yields of E-alkenes are produced, confirming high E-selectivity.  ・ For terminal alkynes, a different stereoselectivity is observed compared to conventional methods. The bromination of the Al intermediate occurs with stereoselective Br addition. (Application Example) ■ Versatile Alkene Synthesis Platform  ・ It is possible to expand into multiple transformation reactions according to applications, starting from substituted alkenes (intermediate A) obtained through this synthesis method. *For more details, please download the PDF or feel free to contact us.

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(Fields where utilization is anticipated) It can be widely used in the development/manufacturing of compounds in pharmaceutical companies, various materials manufacturers, and contract synthesis manufacturers. - Raw materials and intermediates for pharmaceuticals - Raw material monomers for polymers and functional low molecular weight materials - Raw materials for chemical synthesis intermediates

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New Aluminum-Based Complex and Synthesis Technology [Saitama University]

New Aluminum-Based Complex and Synthesis Technology [Saitama University]

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信州TLO

信州TLO

Educational and Research Institutions

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Since our establishment, we have been supporting the commercialization of various companies. We have extensive experience and achievements in commercializing technologies developed at universities and launching new businesses utilizing subsidies. We will introduce researchers and technology seeds suitable for your company's products, technology development, and research. Please feel free to contact us.

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