Synthesize E-type alkenes with high efficiency!
This technology is a method for synthesizing E-type alkenes in high yield through the selective reduction of alkynes. In conventional methods, the synthesis of E-type alkenes from alkynes had low yield and selectivity, making efficient synthesis difficult. This technology has achieved high-efficiency synthesis of E-type alkenes by developing a novel aluminum-based complex. It is a versatile and low-cost synthesis method that does not require hazardous reagents, gases, or expensive transition metals. Features of the technology: - High yield and high selectivity for synthesizing E-type alkenes from internal and terminal alkynes. - Diverse alkene derivatives can be developed starting from the synthesized substituted alkenes. - No need for safety-considerate equipment or facilities; reactions can be conducted using conventional equipment. *For more details, please download the PDF or feel free to contact us.*
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basic information
(Technical Content) New Hydroalumination Reaction Using a Novel Aluminum Catalyst ■ Using a complex of fluoride salts and di-substituted hydride aluminum ■ Synthesis of substituted alkenes ・ For internal alkynes, high yields of E-alkenes are produced, confirming high E-selectivity. ・ For terminal alkynes, a different stereoselectivity is observed compared to conventional methods. The bromination of the Al intermediate occurs with stereoselective Br addition. (Application Example) ■ Versatile Alkene Synthesis Platform ・ It is possible to expand into multiple transformation reactions according to applications, starting from substituted alkenes (intermediate A) obtained through this synthesis method. *For more details, please download the PDF or feel free to contact us.
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(Fields where utilization is anticipated) It can be widely used in the development/manufacturing of compounds in pharmaceutical companies, various materials manufacturers, and contract synthesis manufacturers. - Raw materials and intermediates for pharmaceuticals - Raw material monomers for polymers and functional low molecular weight materials - Raw materials for chemical synthesis intermediates
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