A new introduction method for cells called mechanoporation.
- High introduction efficiency even for non-charged substances - Amazing cell survival rate - A lineup prepared for scale-up Portal Bio's products are based on a unique mechanoporation delivery system that enables the efficient introduction of various molecules and drugs into a wide range of cell types. When cells pass through the micropores on specially designed silicon membranes, a transient change occurs in the cell membrane, allowing various substances to be delivered into the cells. Additionally, this technology can be used not only as standalone products but also integrated into other companies' infusion devices. This opens up innovative possibilities across various fields, from life sciences research to the development of large-scale cell therapies.
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basic information
■Target for introduction: Cultured cells (primary blood cells, primary immune cells, various stem cells, established cell lines, etc.) ■Substances for introduction: mRNA/siRNA/saRNA, CRISPR RNPs, polymers, low molecules, carbon nanotubes, proteins, peptides, nanoparticles, antibodies, viruses, labeling molecules, and others ■Volume range: 50~200µL ■Size and weight: 28.5cm x 16.5cm x 26.0cm height; 3.2kg ■Pressure setting: 3~15psi
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Applications/Examples of results
■ Introduction of various types of substances, drugs, and nucleic acids into cells It is possible to introduce substances that cannot be introduced using electroporation methods (such as non-charged substances). *Since the introduction occurs in the cytoplasm, it is not suitable for applications that require DNA to be introduced into the nucleus. ■ Low damage during introduction, maintaining cell function Cells that would be damaged by electroporation methods (such as primary immune cells and blood cells) can be introduced with a high survival rate while maintaining their cellular functions.
Company information
Neppajine takes pride in contributing to the peace and progress of humanity through biotechnology as a specialized company in life science research equipment, including electroporation (gene introduction using electric pulses) and sonoporation (gene introduction using ultrasound). We believe it is our mission to provide excellent products and information not only within Japan but also to universities, research institutes, hospitals, and private companies around the world. In practice, we have numerous products in use, including gene introduction devices, cell fusion devices, and ultrasound gene introduction devices. We continuously absorb cutting-edge knowledge and technology in biotechnology, engage in close sales activities with our users, provide the latest products, technologies, and information, and respond with a rapid maintenance system. Towards the development of humanity and a bright, happy future, Neppajine will continue to move forward strongly alongside biotechnology.
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