Sugar-modified fluorescent markers for identifying macrophage polarization [Saitama University]
A novel marker for highly sensitive identification of polarized macrophages.
We have developed a mannose-modified fluorescent marker that binds to C-type lectin receptors. By using this fluorescent marker, we can sensitively identify polarized M2 macrophages. The polarization of macrophages is important for the diagnosis of pathological conditions, and this method allows for simple and highly sensitive detection compared to traditional methods using multiple antibodies.
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basic information
To identify the C-type lectin receptor "CD206," over 20 mannoses are modified with pigment proteins (RFP, GFP). ■ Less likely to cause steric hindrance, allowing for multivalency ■ High sensitivity in distinguishing macrophage M1/M2
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Applications/Examples of results
[Demonstration Experiment] Macrophages induced to polarize experimentally were labeled with each marker and measured using a flow cytometer. As a result, the M1/M2 of macrophages using antibodies (fluorescent labeling) showed different waveforms and were difficult to separate, whereas with the developed product (mannose-modified RFP), the M1/M2 of macrophages showed separated waveforms, making identification possible.
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