Gene introduction into hematopoietic stem cells using lipid nanoparticles (LNP).
This is a kit for producing LNPs optimized for the delivery of mRNA or Cas9 mRNA/sgRNA to CD34+ hematopoietic stem cells. It is an ideal kit for customers considering future clinical applications, as it enables ex vivo gene introduction and genome editing for research purposes.
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basic information
■Optimal LNP formulation: Our proprietary LNP formulation enables the introduction of RNA with high transfection efficiency (the composition of the LNP includes ionizable lipids that are clinically usable under license). ■High knockout efficiency: Achieves highly efficient gene knockout and protein expression in a dose-dependent manner. ■High cell recovery rate and high differentiation potential: Maintains high cell viability and differentiation potential even after genome editing. ■Scalable production from exploration to non-clinical: By utilizing NanoAssemblr equipment, it is possible to produce LNPs in quantities suitable for ex vivo cell therapy research from exploration to non-clinical stages. ■Validated workflow: Optimized and validated manufacturing workflow for CD34+ hematopoietic stem cells.
Price information
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Applications/Examples of results
The CD34+ HSC LNP kit can be used with the NanoAssemblr Spark and NanoAssemblr Ignite devices. Additionally, through Cytiva's BioPharma Services, development of scaling processes and GMP manufacturing is possible. By combining the CD34+ HSC LNP kit with the NanoAssemblr platform, robust and consistent performance can be achieved with both Spark and Ignite devices, allowing for seamless scaling changes from exploratory research to non-clinical trials.
Company information
Neppajine takes pride in contributing to the peace and progress of humanity through biotechnology as a specialized company in life science research equipment, including electroporation (gene introduction using electric pulses) and sonoporation (gene introduction using ultrasound). We believe it is our mission to provide excellent products and information not only within Japan but also to universities, research institutes, hospitals, and private companies around the world. In practice, we have numerous products in use, including gene introduction devices, cell fusion devices, and ultrasound gene introduction devices. We continuously absorb cutting-edge knowledge and technology in biotechnology, engage in close sales activities with our users, provide the latest products, technologies, and information, and respond with a rapid maintenance system. Towards the development of humanity and a bright, happy future, Neppajine will continue to move forward strongly alongside biotechnology.
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