Reagents for lipid nanoparticles (LNP) for RNA drug delivery.
○Reagent kit for NanoAssemblr Ignite and Ignite+ ○Contents include ionizable lipid mix and buffer ○Used for RNA screening and delivery validation, contributing to the acceleration of non-clinical trials and clinical evaluations.
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basic information
■An optimized ionizable lipid mixture that accelerates the selection of lead candidates in RNA-LNP delivery ■By using this reagent and protocol, it is possible to easily and quickly produce high-quality and stable LNPs ■The use of the NanoAssemblr NxGen platform allows for easy scale-up ■Includes proof-of-concept data for in vitro protein expression and in vivo immunogenicity in mRNA vaccine applications, demonstrating the reproducibility and stability of LNPs for clinical and commercial manufacturing
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Applications/Examples of results
This kit simplifies the screening of RNA payloads and the optimization of lead candidates based on their physicochemical properties and efficacy, accelerating the selection of lead candidates for RNA drug delivery. By using the RNA delivery LNP kit, it is consistently possible to produce high-quality LNPs. The encapsulated nucleic acids are protected, and important quality characteristics (COA) and activity are maintained over time.
Company information
Neppajine takes pride in contributing to the peace and progress of humanity through biotechnology as a specialized company in life science research equipment, including electroporation (gene introduction using electric pulses) and sonoporation (gene introduction using ultrasound). We believe it is our mission to provide excellent products and information not only within Japan but also to universities, research institutes, hospitals, and private companies around the world. In practice, we have numerous products in use, including gene introduction devices, cell fusion devices, and ultrasound gene introduction devices. We continuously absorb cutting-edge knowledge and technology in biotechnology, engage in close sales activities with our users, provide the latest products, technologies, and information, and respond with a rapid maintenance system. Towards the development of humanity and a bright, happy future, Neppajine will continue to move forward strongly alongside biotechnology.
