Filler×JNC - メーカー・企業と製品の一覧

Antibody purification chromatography "Cellufine SPA-HC"

A highly reusable resin in which alkaline-resistant protein A is immobilized on cellulose particles that have significantly improved pressure resistance through a unique bridging method.

Cellufine SPA-HC is a highly reusable resin that immobilizes alkaline-resistant Protein A on porous cellulose particles, significantly improving pressure resistance through a unique crosslinking method. With proprietary particle manufacturing technology developed over 40 years of industry experience, it achieves high adsorption performance at high flow rates. Designed as a filler for actual manufacturing scales, it allows for the utilization of existing equipment while achieving reduced lead times. 【Features】 ■ Excellent dynamic binding capacity Achieves excellent dynamic adsorption even with short residence times Over 50 mg/mL excellent adsorption performance at a residence time of 2 minutes ■ High pressure resistance and liquid permeability Achieves high flow rates at low pressure through unique crosslinking technology At an operating pressure of 0.3 MPa, liquid flow is possible at a flow rate with a residence time of 2.4 minutes ■ Robust performance independent of antibody type Maintains high adsorption performance even with different monoclonal antibodies Enables robust downstream development ■ Excellent reusability Immobilizes highly alkaline-resistant recombinant Protein A Achieves excellent alkaline resistance *For more details, please refer to the PDF document or feel free to contact us.

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Chromatography

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Virus purification chromatography "Cellufine Sulfate"

Cellufine Sulfate allows for the easy operation of purifying and concentrating virus particles with good reproducibility.

Cellufine Sulfate is an affinity chromatography resin used for virus purification. It has a proven track record of use in vaccine manufacturing by global pharmaceutical companies worldwide. The density gradient ultracentrifugation method used for virus purification has several drawbacks, including lead time, reproducibility, and safety issues. Cellufine Sulfate can address these shortcomings due to its chromatography capabilities. 【Features】 ■ Affinity activity for live viruses, inactivated viruses, and split viruses ■ Affinity for virus-derived antigens, bacteria-derived antigens, and heparin-binding proteins ■ The chromatography process is closed, ensuring high safety and low risk of microbial contamination ■ Effective in removing endotoxins that may have contaminated the manufacturing process, as it does not adsorb endotoxins ■ Due to its negatively charged ligands, it does not adsorb positively charged impurities such as host-derived DNA ■ Physically robust and highly durable as it is based on cellulose ■ Sterilization through multiple autoclave cycles is possible *For more details, please refer to the PDF materials or feel free to contact us.

企業：JNC
価格：Other

Chromatography

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Data: Two-step purification of monoclonal antibodies using Cellufine.

Case study of mAb purification using Protein A resin (Cellufine SPA-HC) and mixed-mode resin (Cellufine MAX IB).

"Cellufine" is a chromatography resin that has various ligands (functional groups) modified on the surface of spherical porous cellulose particles. It is used in the manufacturing of biopharmaceuticals such as antibody drugs, vaccines, and protein formulations. This document reports a method to achieve high-purity purification of monoclonal antibodies through a two-step purification process using the Protein A resin Cellufine SPA-HC for the capture step and Cellufine MAX IB for the polishing step. Since it allows for high-purity purification in two steps, it can streamline the process and reduce lead times. We encourage you to read it. [Contents (partial)] ■ Overview of purification ■ Protein A chromatography ■ Mixed-mode chromatography ■ Summary *For more details, please refer to the PDF document or feel free to contact us.

企業：JNC
価格：Other

Other purification and extraction

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Ion exchange chromatography resin "Cellufine MAX GS"

Achieving high dynamic adsorption performance! Introducing flow rate characteristics, chemical stability, and stationary cleaning, among others!

This document is a technical data sheet published about the ion exchange chromatography resin "Cellufine MAX GS." The base carrier uses highly cross-linked cellulose particles, allowing for operation at high flow rates. The ligand structure is designed to efficiently separate monomers and aggregates of monoclonal antibodies. We introduce topics such as "separation of monomers and aggregates of monoclonal antibodies" and "separation characteristics of model proteins." We encourage you to read it. [Contents (partial)] ■ About Cellufine ■ Cellufine MAX GS ■ Dynamic binding capacity of Cellufine MAX GS ■ Separation of monomers and aggregates of monoclonal antibodies ■ Flow rate characteristics of Cellufine MAX GS *For more details, please refer to the PDF document or feel free to contact us.

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Chromatographic resins and packing materials

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[Information] Chromatography resin 'Cellufine ET Clean'

A new chromatography resin for removing endotoxins! Introduction to the technical data sheet.

"Cellufine ET Clean" is a chromatography resin that immobilizes ε-polylysine on cellulose particles. By strongly adsorbing endotoxins present in the sample solution onto the resins, it enables the removal of endotoxins from the sample. This document provides a detailed explanation of the product features and examples of endotoxin removal using graphs. We encourage you to read it. [Contents (partial)] ■ A new chromatography resin for endotoxin removal ■ Chemical structure ■ Product features ■ Selectivity for endotoxins (LPS) from bovine serum albumin (BSA) ■ Endotoxin removal performance from various proteins *For more details, please refer to the PDF document or feel free to contact us.

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Chromatographic resins and packing materials

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Case study on the purification of the influenza virus: "Cellufine Sulfate"

Introduction of usage examples! This is the technical data sheet for Cellufine Sulfate.

"Cellufine Sulfate" is an affinity chromatography resin that has binding activity to viruses and serum proteins. It can be used for the purification of viruses, virus-derived antigen proteins, serum proteins, and heparin-binding proteins. This document presents a case study of the purification of influenza virus derived from chicken egg culture. By passing a near-neutral culture solution through it and increasing the salt concentration, the virus can be eluted, allowing for simple and efficient purification and concentration of the virus. *You can download the English version of the catalog. *For more details, please refer to the PDF document or feel free to contact us.

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Chromatographic resins and packing materials

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Biopharmaceutical chromatography packing material "Cellufine"

It is a chromatography resin for the purification of domestically produced biopharmaceuticals. We provide high-performance products backed by over 40 years of manufacturing experience in a stable manner.

"Cellufine" is a resin to chromatography used for the purification of antibody drugs such as monoclonal antibodies, biopharmaceuticals like proteins and enzymes, vaccines, virus particles, and food additives. Due to its spherical cellulose particles, it has mechanical strength and high biocompatibility, making it widely used for the purification of biopharmaceuticals. With over 40 years of manufacturing experience, it has been adopted by global pharmaceutical companies around the world. Additionally, as it is derived from natural polysaccharides, it has a lower level of leachables compared to synthetic polymers. 【Features】 - Adopted by pharmaceutical companies worldwide for the purification of biopharmaceuticals - Can be operated at high flow rates - High adsorption performance allows for cost improvements in the manufacturing process - Lower leachables compared to synthetic polymers due to being made from natural polysaccharides - Manufactured under an ISO9001 quality system *For more details, please refer to the PDF document or feel free to contact us.

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Chromatography

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Efficient removal of endotoxins with 'Cellufine ET Clean'

Cellufine ET Clean can efficiently remove endotoxins produced by gram-negative bacteria under conditions such as saline solution.

Cellufine ET Clean is a chromatography resin that immobilizes poly-ε-lysine on spherical cellulose particles. It can efficiently remove endotoxins from the target sample solution. Cellufine ET Clean can effectively remove endotoxins produced by gram-negative bacteria under conditions such as physiological saline. Since endotoxins do not elute even under high salt concentration conditions, it can be suitably used when endotoxins need to be removed from proteins. The product is available in two types: Cellufine ET Clean S: Small pores, resulting in less non-specific adsorption of proteins. Cellufine ET Clean L: Large pores, capable of adsorbing a large amount of endotoxins. 【Features】 - Adsorbs endotoxins at high salt concentrations. - At high salt concentrations where endotoxins are adsorbed, proteins pass through. - Efficiently removes endotoxins from proteins and other substances. - Stable polyamino acids do not become inactive, allowing the use of harsh cleaning solutions. *For more details, please refer to the PDF document or feel free to contact us.

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価格：Other

Chromatography

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Efficient polishing purification of antibody drugs: "Cellufine MAX IB"

Mixed-mode chromatography resin that can be used for polishing purification after protein A chromatography.

"Cellufine MAX IB" is a new mixed-mode resin used for the polishing purification of monoclonal antibodies (Mab) after the purification of Protein A resin. It features surface modification with polyallylamine and the modification of some parts with butyl groups, allowing proteins to adsorb even at high salt concentrations. 【Features】 ■ Can be used for the polishing purification of antibody drugs ■ After Protein A purification, it can achieve high purity with just one purification step ■ Contributes to reduced lead times and cost savings through a two-step purification process ■ Stable resin that allows for in-place cleaning with 0.5M sodium hydroxide ■ Unique salt tolerance that retains proteins even at high salt concentrations *For more details, please refer to the PDF document or feel free to contact us.

企業：JNC
価格：Other

Chromatography

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Cellufine MAX GS exhibits excellent effectiveness in the removal of antibody aggregates.

A strong cation exchange chromatography resin that can effectively separate aggregates of monoclonal antibodies, which are problematic in the purification of antibody drugs.

Cellufine MAX GS is a second-generation chromatography resin that allows for use at higher flow rates. By utilizing surface modification technology, it can be used at high flow rates while also possessing high dynamic binding capacity. It can be used as a high-performance chromatography resin, which is expected to enhance downstream processing capacity. Cellufine MAX GS is a new strong cation exchange chromatography resin optimized for ligand concentration. It demonstrates excellent performance in removing aggregates from monoclonal antibodies. 【Features】 - Can be used for polishing purification of antibody drugs - Capable of separating antibody dimers and aggregates - Unique salt tolerance that allows protein adsorption even at high salt concentrations - Excellent flow rate characteristics due to advanced crosslinking technology - Contributes to the reduction of the amount of support used due to high adsorption capacity *For more details, please refer to the PDF document or feel free to contact us.

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Chromatography

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[Data] Comparison of Cellufine Cation Exchange Chromatography

Technical Data Sheet for Cellufine Ion Exchange Chromatography resin

Cellufine offers a range of ion exchange chromatography resins. Each resin has its own characteristics, and it is important to select the resin that is suitable for the purification of the target protein. This document introduces the features of each resin sold as Cellufine cation exchange chromatography. We encourage you to read it. *You can download the English version of the catalog. *For more details, please refer to the PDF document or feel free to contact us.

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Other purification and extraction

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[Information] Mixed-mode resin "Cellufine MAX IB"

Mixed-mode chromatography resin that can be used for polishing purification after protein A chromatography.

"Cellufine MAX IB" is a new mixed-mode resin used for the purification of monoclonal antibodies (Mab) after the purification of Protein A resin. By surface modification of polyallylamine and modifying some of it with butyl groups, it has the characteristic of protein adsorption even at high salt concentrations. This document introduces the basic features and chemical stability. Please take a moment to read it. [Contents (partial)] ■ Flow rate characteristics of Cellufine MAX IB ■ Cellufine MAX IB with excellent salt resistance ■ Recommended cleaning solution (CIP) ■ Mab purification after Protein A chromatography ■ Conclusion *For more details, please refer to the PDF document or feel free to contact us.

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Other purification and extraction

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[Data] Column Packing of Cellufine Sulfate

Using stable cellulose particles with high physical strength! There is also a proven track record of use in large columns.

"Cellufine Sulfate" is an affinity chromatography resin. It can be used for the concentration and purification of viruses, removal of pyrogens from viruses, purification of virus-like particles (VLPs), and purification of proteins with affinity activity, such as bacterial-derived antigens and serum-derived proteins. This document includes flow packing procedures and examples of packing columns with inner diameters of 3.2 cm, 30 cm, and 45 cm. We encourage you to read it. [Contents (partial)] ■ Flow packing procedures ■ Example of packing a 3.2 cm inner diameter column ■ Example of packing a 30 cm inner diameter column ■ Example of packing a 45 cm inner diameter column ■ Results and discussion *For more details, please refer to the PDF document or feel free to contact us.

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Chromatographic resins and packing materials

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Purification of monoclonal antibodies from CHO cell culture supernatant using Cellufine.

Introducing a method for purifying monoclonal antibodies derived from CHO cells at high purity! Monoclonal antibodies can be purified at high purity using three Cellufine products.

"Cellufine" is a chromatography resin that has various ligands (functional groups) modified on the surface of spherical porous cellulose particles. It is used in the production of biopharmaceuticals such as antibody drugs, vaccines, and protein formulations. This document presents an example of high-purity purification from CHO cell culture supernatant using Cellufine in a three-step process. We encourage you to read it. [Contents (partial)] ■ Purification procedure ■ Protein A chromatography process (Cellufine SPA-HC) ■ Virus inactivation by acid treatment ■ Anion exchange chromatography process (Cellufine MAX Q-h) ■ Cation exchange chromatography process (Cellufine MAX GS) *For more details, please refer to the PDF document or feel free to contact us.

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Other purification and extraction

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Cellufine is optimal for the purification of pneumococcal vaccines.

We introduce two chromatography resins for the high-purity purification of pneumococcal vaccines. Polysaccharide vaccines can be purified with high purity and high recovery rates.

Streptococcus pneumoniae is one of the major pathogens causing high levels of morbidity and mortality from pneumonia worldwide, particularly in children and the elderly. Pneumococcal vaccines based on the capsular polysaccharide (CPS), one of the most important virulence factors, are used to prevent these infections. By using a two-step chromatography purification process for the purification of capsular polysaccharides, it is possible to obtain high-purity vaccines. This process employs hydrophobic interaction chromatography (HIC) and anion exchange chromatography (AEX). We introduce two optimized chromatography media for this process: Cellufine MAX Butyl HS and Cellufine MAX Q-hv. This document provides a detailed explanation of the product features and practical examples related to the chromatography purification of pneumococcal vaccines. We encourage you to read it. *For more details, please refer to the PDF document or feel free to contact us.*

企業：JNC
価格：Other

Chromatographic resins and packing materials

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Filler×JNC - メーカー・企業と製品の一覧

Fillerの製品一覧