extract Product List and Ranking from 92 Manufacturers, Suppliers and Companies

Koshiro no Sendangusa Extract "Miyako TS Extract"

The recommended blending ratio is 0.1%! Introducing plant extracts that are expected to have strong anti-inflammatory effects.

"Miyako TS Extract" is a plant extract derived from the Tachiawayuki Sendangusa, which grows in the weakly alkaline soil formed by the coral reefs of Miyako Island. Due to the environment of Miyako Island, special cultivation methods, harvesting, and processing techniques, it is expected to have a high anti-inflammatory effect. Please feel free to contact us when you need it. 【Specifications (partial)】 ■ Recommended blending ratio: 0.1% or more ■ Full ingredient list: Koshironosendangusa extract 2%, BG 30%, water 68% ■ Product packaging: 1kg bottle, 10kg can ■ Country of final manufacture: Japan *For more details, please refer to the PDF document or feel free to contact us.

Company：ティックファイン
Price：Other

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Gardenia extract "Crocetin 10"

Traditionally used as medicinal herbs, natural pigments, and spices! Natural carotenoids.

"Crosetin 10" is a natural carotenoid extract from the fruit of gardenia. Traditionally used as an herbal medicine, natural pigment, and spice. Additionally, it has a smaller molecular weight compared to common carotenoids, allowing for rapid absorption in the human body, and it does not accumulate in the body over long periods. 【Features】 ■ Smaller molecular weight compared to common carotenoids ■ Rapid absorption in the human body ■ Does not accumulate in the body over long periods *For more details, please refer to the PDF document or feel free to contact us.

Company：海佑商事
Price：Other

Food ingredients (powder)
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Natural Herbal Extract

We manufacture and supply a wide variety of natural herbal extracts.

<Natural Herb Extracts> Currently, our company handles various products from different countries of origin, including Japan, Europe, India, and China, and the volume and variety of our offerings have been increasing year by year. Additionally, we have developed, improved, and formulated our own products independently. We believe that through the stable supply of raw materials for domestic sales, exports, and imports, we are able to contribute to your needs. We also accommodate small quantity orders and contract manufacturing, so please feel free to contact us.

Company：MT（MATERIAL TECHNOLOGY）トレーディング
Price：Other

Organic Natural Materials
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Coated Curcumin

This is a curcumin with a 95% curcuminoid standard that has improved handling in the manufacturing site!

This is a material extracted from the rhizome of turmeric grown in India. It is curcumin that has been coated to improve handling in the manufacturing process due to its strong pigment. 【Features】 - Antioxidant - Anti-inflammatory - Immune system enhancement - Skin beautifying effects (prevention of spots and wrinkles) - Improvement of brain function - Prevention of periodontal disease 【Recommended dosage forms】 Tablets/Capsules, Powder

Company：ニゾナ
Price：Other

Food ingredients (powder)
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Kojiesse(TM) Koji Mold Cultivation Extract Powder

It contains a variety of enzymes, vitamins, and minerals.

"Kojiesse(TM)" is a koji culture extract powder fermented with high enzyme activity using natural plants such as black soybeans, wheat, barley, rice bran, black sesame, and germinated brown rice. It is cultured aseptically to prevent contamination by foreign bacteria and dried at low temperatures to retain enzyme activity while converting it into powder form. Please feel free to contact us if you have any inquiries. 【Features】 ■ Unique manufacturing method ■ High enzyme activity ■ Gluten-free koji ■ Koji mold *For more details, please download the PDF or feel free to contact us.

Company：オトコーポレーション
Price：Other

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Kiwi Extract "Kipofen (R)" [Functional Food Labeling Compliant]

Raw material GMP and ISO 22000 compliant / Domestic evidence for "improvement of weight, body fat, waist, and BMI."

Kiwi fruit is known for being rich in vitamin C and dietary fiber, but it contains only about 0.3% polyphenols. Our company has clarified that this rare polyphenol, "kiwi-derived procyanidin," has an inhibitory effect on lipid-degrading enzymes (lipase) and has developed it as a functional food ingredient. This product is manufactured at our factory in Susono City, Shizuoka Prefecture (which has obtained raw material GMP (JIHFS) and ISO 22000:2018 (SGS) certification). In domestic clinical trials, a suppression of postprandial blood triglyceride levels has been observed, and this effect size corresponds to the inhibition of absorption equivalent to 15g of lipids. KipoFen is recommended for supporting body fat and BMI management across a wide range of ages, as it can suppress lipid absorption while prioritizing the enjoyment of everyday eating rather than merely aiming for weight loss. [Example of Functional Claims] This product contains kiwi-derived procyanidin. Kiwi-derived procyanidin has been reported to support weight loss in individuals with a higher BMI by suppressing lipid absorption, reducing body fat and abdominal circumference, and improving elevated BMI.

Company：オムニカ
Price：Other

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Bilberry Extract "Mirtolgos (R)" [Functional Food Labeling Compliant]

Raw materials compliant with GMP and ISO 12000 / Evidence in Japan for "improvement of eye fatigue, focus adjustment, and dryness" as well as "dynamic vision, depth perception, and night vision."

Our bilberry extract uses fruits that are frozen within 24 hours of harvest in Scandinavia and is manufactured at our own factory in Susono City, Shizuoka Prefecture (certified for health food GMP (JIHFS) and ISO22000:2018 (SGS)). It has been confirmed that, due to our patented manufacturing method (No. 7307757), the absorption rate is approximately twice as high, and up to six times higher compared to commercially available bilberry extracts. We are also focusing on accumulating evidence through domestic clinical trials using the raw materials themselves (targeting Japanese subjects), and we have received acceptance for functional claims related to "eye focus adjustment function," "eye fatigue," and "eye moisture." Furthermore, recent research findings have confirmed effects on improving "dynamic visual acuity," "depth perception," and "night vision" (with notifications planned soon). We utilize an on-site analysis center for manufacturing, conducting over 200 samplings per lot to manage the process. Through strict quality control, we can deliver the same raw materials used in the domestic clinical trials, ensuring that the evidence confirmed in the trials can be expected. <Series Lineup> - Functional food-specific "BBE MWA-FFC" - General-purpose types "Mirtol Argos (R)" and "VMA25/37"

Company：オムニカ
Price：Other

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Profine

Domestic fermented ingredient that concentrates free amino acids by fermenting sake lees with yeast once again.

Profine is a fermented material created by powdering sake lees that have been re-fermented from the sake brewing process. It contains 10 to 20 times more free amino acids compared to sake, making it a functional ingredient. Profine also has good solubility, and its effects, such as stress relief, improved endurance, and beauty benefits, have been confirmed. *For more details, please visit our company website or feel free to contact us.*

Company：ヤヱガキ醗酵技研
Price：10,000 yen-100,000 yen

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Natural seasoning ingredient: Ohly company food yeast extract

Expanding the market for natural seasoning ingredients both domestically and internationally! We offer a variety of types.

Higuchi Shokai handles "food yeast extract" from Ohly, a long-established yeast extract manufacturer in Germany. We offer a variety ranging from standard free amino acid-rich types to nucleic acid-rich types, peptide-rich types, and reaction types. Available in powder, paste, and liquid forms, they are used not only for seasoning purposes but also in fields such as improving palatability in pet food. 【Product Lineup】 ■ Free amino acid-rich type - adds umami and enhances base flavor ■ Nucleic acid-rich type - adds umami ■ Peptide-rich type - adds richness and enhances aftertaste ■ Reaction type - adds meatiness and cooking sensation, etc. *For more details, please refer to the PDF document or feel free to contact us.

Company：HIGUCHI INC.
Price：Other

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Ohly Company Yeast Extract for Culture Medium

Introduction of yeast extract for culture media, widely used in the fermentation industry, starting with lactic acid bacteria cultivation.

Higuchi Shokai handles "Yeast Extract for Culture Media" from Ohly, a long-established yeast extract manufacturer in Germany. We offer a lineup that includes the high free amino acid-rich type "Yeast Peptone Standard type F," which has a high protein decomposition rate, and the peptide-rich type "Flav-R-Tide LS." 【Lineup】 ■ Yeast Peptone Standard type F - High free amino acid-rich type with a high protein decomposition rate ■ Flav-R-Tide LS - Peptide-rich type ■ Flav-R-Ound LS - Nucleic acid-containing type ■ Yeast Peptone MAX - Nucleic acid-rich type (high content) *For more details, please refer to the PDF document or feel free to contact us.

Company：HIGUCHI INC.
Price：Other

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Cosmetic ingredients, Tasmanian origin, high purity, anti-aging fucoidan (wakame extract)

Cosmetic ingredients, Tasmanian origin, high purity, anti-aging fucoidan (wakame extract), anti-pollution, virus protection, UV damage recovery.

- Ingredients: Contains Fucoidan ≧ 85% - Efficacy: 1) Anti-aging function - Wrinkle depth: -9% - Stimulation of anti-aging gene SIRT1 expression (+28%) - Glycation inhibition effect (-50%) - Inhibition of collagenase and elastase by up to 99% 2) Protection effect - Suppression of erythema after UV exposure by 45% - Antiviral effect (multiple including herpes simplex) 3) Moisturizing and smoothing - Increase in moisture by 30% after UV exposure - Increase in stimulation of skin cell expression after UV exposure - Inhibition of myeloperoxidase by up to 99%

Company：HIGUCHI INC.
Price：Other

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Cosmetic ingredient: Liftis, a lifting and wrinkle improvement ingredient derived from baobab fruit.

Baobab fruit pulp-derived, instant lift-up effect, brightness enhancement, smoothness improvement, upcycling, moisturizing effect, galacturonic acid, alpha hydroxy acid.

The Baobab (scientific name: Adansonia) is a deciduous tree native to regions such as Africa and Madagascar, belonging to the Malvaceae family and the Baobab genus. In Africa, its fruit has been consumed as a panacea since ancient times and is referred to as the "Tree of Life." The trunk of the Baobab tree has a shape resembling a sake bottle, is hollow inside, and can store up to 10 tons of moisture in its trunk, allowing it to survive by shedding its leaves and entering dormancy during the dry season, relying on the moisture stored within its trunk. LIFTISSTM is an extract obtained from the fruit of this Tree of Life, and it is a gel-like product rich in organic acids (AHA) and natural moisturizing factors (NMF), containing natural sugar components (77% galacturonic acid). <Mechanism of Action> Organic acids (alpha-hydroxy acids) break down keratin on the skin's surface, promoting exfoliation and epidermal regeneration, resulting in smoother skin and providing moisturizing and wrinkle-smoothing effects. Natural sugars (components of NMF), such as glucose and xylose, bind with keratin to form complexes that attract water molecules, thereby providing moisturizing effects. Additionally, natural sugars form a film on the epidermis, creating a tightening effect. <Efficacy> - Number of wrinkles: -41% - Area of wrinkles: -24% - Lifting effect, etc.

Company：HIGUCHI INC.
Price：Other

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Hair care ingredient: Linden bud extract, hair care material: Chilisin.

Patent method cryo-extraction, linden bud extract, hair moisturizing, cuticle improvement, scalp moisture enhancement, hair coating, polysaccharides, sugars.

This product is an extract derived from the new buds of linden using GREENTECH's patented cryo-extraction technology. Linden is a long-lived tree that can live for centuries and was considered a sacred tree in ancient Germany. The extract of its flowers has anti-inflammatory and protective properties and has been used for various purposes. In particular, the new buds consist of embryonic tissue from the proliferation process, are full of vitality, and are rich in active components necessary for growth, such as plant hormones, proteins, amino acids, and sugars. The company's patented technology allows for the preservation and extraction of the active components of the new buds without damage. <Mechanism> It forms a film on the surface of the hair, suppressing moisture release, protecting the cuticle, smoothing the hair surface, and making it less prone to tangling. Additionally, by simultaneously providing flavonoids, the helical bonds of keratin (the fibrous protein that makes up 95% of hair) are stabilized. Furthermore, using free sugars (components of natural moisturizing factors) forms a water complex in the upper layer of the scalp, providing constant hydration. <Efficacy> - Improvement in hair moisture levels: +83% - Improvement in scalp moisture levels: +33% - Cuticle improvement - Volume enhancement - Static electricity prevention

Company：HIGUCHI INC.
Price：Other

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Hair care ingredient: scalp microbiome anti-dandruff effect extract Dandrilis

Very popular in Southeast Asia! Improves scalp itchiness and dandruff. With a high long-lasting sebum control effect, it adjusts the scalp's microbiome (bacterial flora).

Dandruff is a scalp disorder that affects 50% of the world's population and is said to impact men more than women. Dandruff causes itching and skin flaking along with mild irritation and inflammation. In addition to discomfort and the worsening appearance of the scalp, dandruff also affects self-esteem and confidence from social and psychological perspectives. Current treatments often use zinc pyrithione overseas, which is known to have strong effects but also side effects such as skin irritation, dryness, and allergies. GREEN TECH has developed Dandrilys, a natural active ingredient that controls the scalp microbiome, cleanses the scalp, and effectively removes dandruff, redness, and sebum, as an alternative to products with side effects like zinc pyrithione. In Vivo: Examined with shampoo containing 1% Dandrilys. - Control of fungal and bacterial flora - One-week sebum suppression effect - Duration of dandruff suppression effect: 72 hours - Dandruff suppression effect: 83% improvement - Itch suppression effect: 86% improvement

Company：HIGUCHI INC.
Price：Other

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Cosmetic Ingredients Expo Exosome Protection Natural Hair Care Ingredients Zolialis

Expo-some protection, color fading prevention, cortex cuticle protection, keratin fiber maintenance, hair strength maintenance, oxidation prevention, shine enhancement.

The structure of hair fibers is the most important factor for the quality and health of hair. When the fiber structure deteriorates, the shine and smoothness of the hair decrease. Hair is constantly exposed to external stress factors such as sunlight and pollutants. These stress factors are referred to as "exposome." The structure of hair fibers deteriorates due to the exposome, leading to a decrease in the mechanical strength, shine, and smoothness of the hair. ZORYALYS is a raw material composed of three extracts developed to protect hair from the exposome. The extracts used are derived from ginger root, magnolia bark, and placasia, each serving a specific role: ginger provides antioxidant functions, magnolia offers protection against light damage, and placasia oil contains components similar to sebum in hair, improving hair quality. In Vivo (Caucasian, Asian) - Cortex protection against UV-A, cuticle protection, overall hair protection (evaluation of carbonylation) - Protection of keratin fiber structure against xenon (sunlight), prevention of tryptophan (melanin precursor) decomposition, prevention of cysteine participation, maintenance of mechanical strength, improvement of shine (twice as much), prevention of hair color fading.

Company：HIGUCHI INC.
Price：Other

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Cosmetic ingredients: Three approaches to whitening plant extracts - Clerilys.

Whitening, exfoliation, promotion of turnover, suppression of melanin production, inhibition of tyrosinase, suppression of melanin transfer, brightness improvement, improvement of pigmentation.

Aging and pregnancy increase the skin's sensitivity to sunlight, leading to excessive pigmentation and the formation of spots and melasma. The three types of plant extracts included in this product approach spots in three different ways, thereby improving spots and melasma, as well as enhancing skin uniformity and brightness. <Three Approaches> - Mulberry bark extract: Suppresses melanin production through tyrosinase inhibition - Hibiscus flower extract: Promotes turnover by exfoliating dead skin cells - Cucumber seed extract: Inhibits the transfer of melanin to epidermal cells <Efficacy> In Vitro: - Tyrosinase inhibition effect: -18% - Melanin production inhibition: -22% - Melanin transfer inhibition: -22% In Vivo: Brightness improvement: 1.5 times increase Improvement of pigmentation: 6.5 times improvement

Company：HIGUCHI INC.
Price：Other

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Cosmetic ingredient Acne improvement microbiome fruit extract Acniris

Acne improvement, oily skin, sebum regulation, suppression of acne (phylotype IA1), suppression of C. GRANULOSUM, anti-inflammatory, reduction of papules, brightness improvement.

It is said that 85% of individuals aged 12 to 24 struggle with oily and acne-prone skin, and this trend is increasing in older age groups as well. The main causes of acne are (1) excessive sebum production, (2) irregular keratinization, (3) inflammation, and (4) sebaceous gland involvement. These causes lead to inflammatory responses. Furthermore, clogged pores create a low-oxygen environment that facilitates the proliferation of acne bacteria. Whether acne bacteria act symbiotically or worsen acne symptoms depends on the balance of their strain types. There are mainly six strain types of acne bacteria: IA1, IA2, IB, IC, II, and III. It has been confirmed that strain type IA1 is the dominant type in acne-prone skin. This product suppresses the IA1 strain of acne bacteria and the C. granulosum that increases within papules, maintaining and improving the balance of symbiotic bacteria. In Vitro: - Sebum suppression effect: - Inhibition of 5-alpha reductase - Inhibition of acne bacteria IA1 - Anti-inflammatory action In Vivo: - Maintenance of major pore balance - Suppression of C. granulosum - Improvement of acne - Brightness improvement - Uniformity improvement

Company：HIGUCHI INC.
Price：Other

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Hair Care Ingredients Green Tech Hair Care Comprehensive Catalog

Microbiome adjustment, hair growth and stimulation, cuticle improvement, gray hair, anti-dandruff, anti-pollution, UV, IRA, dry oil, scalp care.

- ARCOLYS: Anti-gray hair ingredient - HAIRILINE: Anti-hair loss ingredient, scalp microbiome regulation - DANDRILYS: Anti-dandruff ingredient, scalp microbiome regulation, sebum control - ZORYALYS: Anti-pollution, anti-UV, IRA effect ingredient - TILICINE: Cuticle improvement effect, frizz control effect, scalp care ingredient - INCA INCHI OIL: Dry oil containing 45% omega-3, hair repair effect ingredient - BAOBAB OIL: Sustainable dry oil rich in omega-6 and omega-9 - APRICOT OIL: Oil rich in omega-6 and omega-9 - HAIR STRENGTH EGX292: Scalp care extract mixed with five types of extracts - COMPLEX HAIR LUSTRE: Hibiscus flower extract that softens hair and enhances shine and texture

Company：HIGUCHI INC.
Price：Other

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Cosmetic ingredients: redness suppression, skin tone improvement plant extract (Hawthorn Cosmelean)

Promotes microcirculation, anti-inflammatory, reduces redness, improves skin tone, tone enhancement, hawthorn extract, quasi-drug.

Hawthorn Cosmelean is an extract from the flowers of the Western Hawthorn. It contains an active ingredient, Vitexin-2-O-rhamnoside, at a concentration of 0.07-0.11%. <Mechanism of Action> - The flavonoids contained in Cosmelean Hawthorn reduce congestion in capillaries and alleviate erythema. - By promoting blood flow, it enhances the oxygen levels in the skin, activating a constant process. <Efficacy> Reduces redness in the skin and brightens it. Unifies skin tone and improves transparency. Reduces skin discomfort/unpleasant sensations (tightness due to dryness, inflammation). In Vivo: Redness reduction (IR-induced): -6% Redness reduction (UV-induced): -7%

Company：HIGUCHI INC.
Price：Other

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Cosmetic ingredient soothing extract for sensitive skin, chamomile.

Redness suppression, redness reduction, eye area itch relief, inflammation suppression, soothing effect, calming, sensitive skin.

Chamomile Cosme Ren is a plant extract containing 0.01-0.02% apigenin as an active ingredient derived from chamomile flower extract. <Mechanism of Action> It suppresses the production and release of inflammatory factors that cause redness. It alleviates skin tingling and brings healing. <Efficacy> Soothes the skin and suppresses redness. Relieves tingling sensations. Reduces eye congestion. In Vivo: Redness suppression: -26% Reduction of UV-induced skin temperature increase: -0.2℃

Company：HIGUCHI INC.
Price：Other

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Cosmetic ingredient collagen production, elasticity-improving plant extract Ginseng Cosmelean.

Collagen production promotion, ginseng, ginsenosides, improvement of firmness, improvement of elasticity, anti-aging, anti-wrinkle, tightening, hair care, improvement of dryness.

Ginseng Cosmelean is an extract derived from the root of ginseng, which is used as a tonic and activates the body's functions as a traditional herbal medicine. It contains ginsenosides as its main component. This product is expected to promote collagen production in skin cells, strengthen the extracellular matrix, enhance barrier function, and improve firmness and elasticity. <Mechanism of Action> Ginseng Cosmelean promotes collagen production in skin cells, strengthens the extracellular matrix, and improves elasticity. This product is expected to enhance barrier function and improve firmness and elasticity. *The multifunctional medicinal effects of ginseng have been well known since ancient times. Among these, its anti-aging properties have also been reported, particularly its palliative effects in elderly patients with terminal illnesses. <Efficacy> Improves skin elasticity and enhances firmness. Makes the skin appear youthful. In Vivo: Firmness improvement: up to +9% Elasticity improvement: up to +22%

Company：HIGUCHI INC.
Price：Other

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Cosmetic ingredient collagen production-promoting wrinkle care plant extract Centella

Anti-wrinkle, wrinkle care, Cica, CICA, collagen production promotion, Centella Asiatica leaf extract, asiaticoside, madecassoside, triterpenes.

Centella Asiatica Cosmelean contains triterpenes such as asiaticoside and madecassoside, and is a standardized product. It activates collagen synthesis by fibroblasts and maintains the structure and function of the skin. Triterpenes (asiaticoside and madecassoside) exhibit nutritional and regulatory effects on connective tissue, particularly enriching and regulating fibroblasts and glycosaminoglycans. They promote the synthesis of collagen I and III, enhance keratinization, and accelerate the healing process. In vitro studies have reported that asiaticoside and madecassoside improve the secretion of collagen I, while madecassoside promotes the synthesis of collagen III. In vivo: • Number of moderate wrinkles: -42% • Depth of moderate wrinkles: -3% • Number of deep wrinkles: -29% • Total area of wrinkles: -30%

Company：HIGUCHI INC.
Price：Other

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Cosmetic ingredient Zombie cells (aging cells) suppression Seaweed extract QT40

Zombie cells, collagen production promotion, lift-up, improvement of elasticity and firmness, dermal densification, CCNA2 gene expression, anti-aging.

Green Tech Co. confirmed the inhibitory effect on genes that protect the extracellular matrix and suppress cellular aging using a seaweed extract rich in glucuronic acid oligosaccharides against 44,000 human genes with DNA microarrays, and developed QT40. This product is a raw material that provides a lifting effect by inhibiting zombie cells and promoting extracellular matrix structural proteins. In Vitro: FGF1 gene expression stimulation: +35% CCNA2 gene expression stimulation: +80% *CCNA2 has a function that promotes cell cycle progression as a DNA repair and p21 inhibitor, and is expected to prevent cellular aging and the emergence of zombie cells. Collagen synthesis: +22% Hyaluronic acid synthesis: +17% MMP1: -29% MMP3: -31% In Vivo: Improvement of sagging: 2.8 times improvement V-line tightening: Over 60% of subjects experienced it Improvement of elasticity: +20.5%

Company：HIGUCHI INC.
Price：Other

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Body care ingredient African traditional breast enhancement plant extract Kigerin

Bust up, African tradition, bust lift up, sausage tree, France No.1, saponin, flavonoid, firmness improvement, elasticity improvement.

KIGELINE(R)/Kigerin is an extract from the fruit of Kigelia africana (sausage tree), used as a traditional African breast enhancement agent. This product is the best-selling item from Green Tech in France. <Main Ingredients> Saponins, Phytosterols, Flavonoids <Mechanism of Action> Saponins and phytosterols act on dermal fibroblasts, promoting the synthesis of hyaluronic acid and collagen. The increase in these extracellular matrix components contributes to improving skin firmness and elasticity, as well as increasing skin moisture retention, thereby enhancing the firmness and fullness of the breasts. Flavonoids exhibit anti-aging effects by promoting blood circulation. The additive effects of these three components provide firmness and elasticity to the breasts, resulting in a lift. <Efficacy> Breast enhancement effect: Lifts the breasts by improving skin elasticity and moisture retention. Anti-aging effect: Beautifies the neck line through improved firmness. <In Vivo> Accuracy measurement by iconography - Breast enhancement: +70% - Lift: +18%

Company：HIGUCHI INC.
Price：Other

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Cosmetic ingredients for eye area care with glycation inhibition, highland plant extract, Miralis.

Alpine plants, gentian, glycation inhibition, eye bags, eyelid sagging prevention, eye care, organic, extracellular matrix reinforcement, antioxidant, anti-inflammatory.

The eyes are said to be the most important part of interpersonal communication. During the COVID-19 pandemic, the market for eye care products has expanded as wearing masks has become the norm. Miralis is an extract obtained from the roots of the gentian, a high-altitude plant, harvested using sustainable methods, and standardized for its active ingredient, gentiopicroside. <Mechanism of Action> It suppresses six aging-promoting pathways and cares for the eyelids (upper part of the eye), tear troughs, under-eye bags, and dark circles. - Glycation suppression - Extracellular matrix aging suppression - Antioxidant - Anti-inflammatory - Lymphatic drainage promotion - Angiogenesis suppression <In Vitro> - NRF2: +21% - VEGF-A: -15% - Collagen 1 synthesis promotion: +76% - Glycation suppression Activation of glyoxalase 1: +35% Suppression of AGE (carboxymethyllysine) production: -111% - UV protection: Elastin protection: +41% <In Vivo> - Eyelid wrinkle depth: -22% - Tear trough depth: -14% - Under-eye bag swelling: -18% - Dark circle color: -14%

Company：HIGUCHI INC.
Price：Other

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Cosmetic ingredient Active plankton extract Silidine

Plankton extract rich in active ingredients, cultivated under excessive oxidative stress. Stimulates endothelin-1 and improves erythema and swelling in the legs.

SILIDINE is a plankton extract made from microalgae rich in nutrients, cultivated under excessive oxidative stress. By cultivating it under sunlight, the excessive oxidative stress causes changes in the cellular phenotype, resulting in a high concentration of low molecular weight oligosaccharides and the bioaccumulation of trace elements from the culture medium in the microalgae extract. <Mechanism of Action> - It induces the expression of the endothelin-1 gene. The endothelin-1 gene stimulates the contraction of veins and improves blood retention. It helps improve acne and erythema caused by swelling and inflammation. When applied to the feet, SILIDINE alleviates heaviness and fatigue in the legs. <Efficacy> Reduction of facial redness: 19% improvement (improvement confirmed in 86% of subjects) Reduction of leg swelling: 36% improvement Immediate effects: moisturizing, refreshing sensation, etc.

Company：HIGUCHI INC.
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Cosmetic ingredient Fermented Raspberry Peeling Extract

This is a raspberry fruit extract with a maximum AHA content achieved through fermentation technology. It restores brightness to the skin through peeling and moisturizing effects.

FERMENT'ACTIVE RASPBERRY is a raspberry fruit extract with an AHA concentration maximized through GREENTECH's fermentation technology. = Mechanism of Action = This product is expected to promote skin regeneration through the exfoliating effects of the high concentration of AHA it contains. = Efficacy = - It leaves the skin hydrated, smooth, and elastic. - It improves the color and shine of hair and skin. = AHA (Citric Acid) Content = It contains 38 times more citric acid than regular raspberries. In hair care, it can be used for moisturizing care.

Company：HIGUCHI INC.
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Cosmetic ingredients (oral care ingredients) - Silymarin-containing milk thistle seed extract

Milk thistle seed extract containing a high concentration of silymarin. It regulates the oral microbiome that suppresses the bacteria responsible for gingivitis, periodontitis, cavities, and plaque.

The milk thistle is a biennial plant that can reach a height of 1.5 meters and is characterized by its green leaves with a marble pattern and white veins. It has been known as a medicinal plant for a long time, and since the discovery of a molecule belonging to the flavonoid group called silimarin (silybin) from milk thistle in 1968, it has been used as a liver treatment. This product is an extract derived from seeds that contain the highest concentration of silybin. <Active Ingredients> Silybin ≧ 25%/MS, Taxifolin ≧ 1%/MS Other components include phenolic compounds, oligosaccharides, polysaccharides, amino acids, and proteins. <Cleansing Effects> - Inhibition of the growth of Porphyridium gingivalis - Inhibition of the growth of Streptococcus mutans - Inhibition of the growth of Streptococcus sobrinus

Company：HIGUCHI INC.
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Cosmetic ingredients for dry and dehydrated skin, microbiome adjustment, holobiosis.

An extract fermented with cold-resistant bacteria from the roots of gentian collected in the French Alps, designed for dry and dehydrated skin with microbiome-regulating ingredients.

This product is an extract fermented with rare cold-resistant bacteria that inhabit the air in France, using the roots of wild gentian organically grown in the high mountains of France. This bacteria is resistant to cold and dry environments, and the holobiosis fermented with it demonstrates effectiveness for dehydrated (water-deficient) and dry (lipid-deficient) skin, showing various efficacy data such as promoting hyaluronic acid synthesis in the epidermis and dermis, antioxidant effects, strengthening barrier functions, and promoting beneficial skin bacteria. Main components: polar lipids, amino acids, loganin acid, swertia amarin. Standardized. In Vitro: Hyaluronic acid synthesis: +62% (keratinocytes), +32% (fibroblasts) CD44 synthesis: +42% (keratinocytes) Lipid synthesis: +147% (keratinocytes) Increase in tight junction-related proteins Increase in basement membrane structural proteins (2 types) Increase in collagen-binding proteins (2 types) Increased expression of antioxidant-related genes (8 types) In Vivo: Skin surface moisture content: +7.3% (all subjects), +12.5% (seborrheic deficiency) Promotion of sebum production: +27% (all), +43% (deficiency) Wrinkle length: -5% Epidermal Staphylococcus: +39% Ralstonia species: +45%

Company：HIGUCHI INC.
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[New Product] Cosmetic Ingredient: Longevity Gene Stimulator, Plant Extract for Improved Skin Lifespan

Time Ris influences longevity genes, achieving improved skin lifespan [Scheduled to exhibit at the Tokyo 2025/Okinawa 2024 Cosmetics Development Expo (Booth: C11-20)]

It is an extract of the natural ruby-colored Chosen Gomi, a symbol of beauty and longevity, with a wide range of health benefits. It works on the skin longevity mechanism, leading to vibrant, radiant, and smooth skin. <Active Ingredients> Lignans: ≥10%/DM Longevity extension mechanism Schisandrin: 6-8%/DM Autophagy induction & improvement of skin health lifespan Organic Acids: Citric Acid: 10-15% Malic Acid: 10-15% Tartaric Acid ≥2% Cellular energy production <Efficacy> Unit: % Vitro SIRT6: +181 FOXO3: +104 Anti-inflammatory (NfkB: -14, IL6: -66, PGE2: -87) Antioxidant (ROS: -16, SOD2: +50, Catalase: +104) Mitochondrial activity: +55 Autophagy (LAMP2A: +80, LC3A: +44) Skin barrier (Cornifin A, Occludin: +32, Filaggrin: +160, MDA: -22, Epidermal thickness: +63) Dermis (Elastin: +16, MMP1: -72) Vivo TEWL: -24 Moisture content: +34 Microcirculation: +33 Radiance: +47

Company：HIGUCHI INC.
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