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medicine×埼玉大学 - List of Manufacturers, Suppliers, Companies and Products

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Unlocking the future with mysterious sugar chains!

Keywords: complex carbohydrates, glycan, organic synthesis, bioorganic chemistry, fluorescence, polymer science, bioactive substances, structure-activity relationship, next-generation antibodies.

The structure formed by sugars like glucose linked together in a chain is called a glycan, and a glycan made up of a few sugars is referred to as an oligosaccharide. The structure of these glycans determines blood types such as type A and type B! Additionally, glycans are involved in infections caused by viruses like influenza. Various glycans are actively functioning in our daily lives. Although there is no medical department, we conduct research and development in drug discovery related to detection, diagnosis, and treatment from an engineering and science perspective. When considering each cell in our body as a giant molecule, it appears that many functional substances (glycans and proteins) are presented on its surface. Therefore, we have discovered that by artificially gathering functional substances to create multivalent (cluster-type) compounds, we can produce substances with enhanced activity. Currently, we are conducting research and development aimed at creating functional substances and inducing multivalent compounds, leading to new drug discovery.

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Enhancing molecular bonds to protect health!

Keywords: glycan, antibody, molecular recognition, multivalent effect, detection reagent

The proverb "When three people gather, the wisdom of Monju" is often heard in our daily lives. Did you know that the power of groups exists even at the molecular level? Glycans facilitate intercellular communication by binding to glycan receptors, but individual glycans have only weak binding strength. However, when multiple glycans come together, their effect far exceeds simple addition, sometimes exhibiting astonishing powers that can be hundreds to hundreds of thousands of times greater. This is called the "multivalency effect." The characteristic of our research is to artificially replicate and further enhance this clever mechanism found in nature. We design artificial molecules that accumulate various molecules, such as glycans and next-generation antibodies, and investigate their interactions in detail. By effectively utilizing the power of molecular cooperation, we hope to contribute to the future of medicine.

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