Trapping reagent
We manufacture and sell four types of trapping reagents that can be used for pharmacokinetic studies and toxicity studies.
These trapping reagents can be used for the detection and analysis of reactive metabolites that may arise during the metabolic processes of drug candidate compounds. ◆R00846 CysGlu-Dan Traditionally, Dansyl-GSH (dGSH) has been used in trapping tests for electrophilic reactive metabolites generated by CYP oxidation; however, Dansyl-GSH was unable to detect "hard" electrophilic reactive metabolites such as aldehydes. CysGlu-Dan, like Dansyl-GSH, can react with "soft" electrophilic reactive metabolites such as quinones and epoxides, as well as with "hard" electrophilic reactive metabolites, allowing for the sensitive detection of a broader range of reactive metabolites. ◆R00845 Dap-Dan This reagent can trap and detect reactive 1-O-acyl glucuronides generated during the glucuronidation process, as well as aldehydes produced through rearrangement. ◆R00847 Cys-Dan This reagent can trap and detect reactive acyl-CoA generated during the metabolic processes of fatty acids. These trapping reagents were developed by a group led by Professor Tomoyuki Oe at the Faculty of Pharmacy, Keio University.
- Company：渡辺化学工業
- Price：10,000 yen-100,000 yen
