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Create organic molecules freely with a new reaction!

Keywords: Organic synthesis, silicon, halogen, catalyst, radical

Organic synthesis is one of the scientific technologies that supports material civilization, and it is used in the production of various products and materials that are beneficial to our lives, such as fuels, oils, fibers, rubber, resins, pharmaceuticals, and food additives. An essential component of organic synthesis is the "reaction," which transforms one molecule into another. In our laboratory, we conduct research with the goal of "developing new reactions that are useful for organic synthesis." In reaction development, we aim to efficiently produce only what we want and to create it in an environmentally friendly manner without waste from readily available raw materials. We also emphasize the originality of our research and chemical discoveries, focusing on the development of novel reactions that have not been seen before, rather than merely improving existing reactions. Various reagents and catalysts are used in organic synthesis, but our laboratory pays particular attention to the reactivity of silicon compounds and halides, as well as the catalytic effects of platinum and palladium. With the aim of making new discoveries, we engage in reaction development with excitement every day.

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Development of biofuel production using microalgae

Keywords: Microalgae, biofuels, renewable energy, decarbonization, carbon neutrality

As environmental changes progress, promoting decarbonization towards the realization of a sustainable society has become a global challenge. We are developing biofuels using microalgae with the aim of creating carbon-neutral renewable energy. The microalga Nannochloropsis accumulates lipids that can reach up to 50% of its cell content and can be cultivated at high densities, which allows us to develop technology for the efficient and high-yield production of lipids using this alga. Meanwhile, we are also advancing the development of an "extracellular production method" for free fatty acids using cyanobacteria, another type of microalgae. The intracellular production method, which involves accumulating fuel substances within the cells, consumes a tremendous amount of energy during processes such as harvesting, drying, and extracting the fuel substances. In contrast, the extracellular production method is expected to significantly reduce costs and has the advantage of being able to produce fuel substances in quantities that exceed the cell volume. The lipids and free fatty acids obtained from the algae can be converted into diesel fuel and other products.

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Create molecules that color sugar.

Keywords: analytical reagents, molecular recognition, supramolecular chemistry, metal complexes, nanoparticles, luminescence, dyes

Various types of sugars exist within living organisms. Each of these plays an essential role in maintaining life and is constantly circulating within the body. Therefore, an imbalance of sugars in the body directly leads to serious diseases that threaten us today (e.g., diabetes). In other words, the development of technology to measure sugar levels is crucial for the early detection of bodily disorders. To develop such technology, I am designing "analytical reagents," which are molecules that glow when they bind to sugars. In my research, I am developing analytical reagents with a simple structure and excellent detection capabilities by using various frameworks (organic dyes, metal complexes, supramolecular complexes, nanoparticles, etc.) as a foundation (Figure 1). So far, I have successfully developed a supramolecular complex-type analytical reagent that specifically fluoresces for D-glucose (blood sugar) among the numerous sugars (Figure 2). I believe that this technology will lead to the development of a diagnostic system for the early detection of diabetes.

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