メルク株式会社ライフサイエンス（シグマ アルドリッチ ジャパン合同会社） List of Products and Services

Our company is a well-established provider of pure water production equipment that accommodates various types such as ion exchange water, RO water, and high-purity water (RO + EDI). There are diverse purification methods for pure water, and the suitable pure water equipment varies depending on the application. By introducing the right pure water system for your needs, it is possible to enhance the reliability and reproducibility of the expected results. This document includes fundamental knowledge about pure water, as well as reference data that will help in selecting equipment. 【Recommended for those who:】 ■ Want to understand the differences in purification methods and water quality of pure water ■ Want to know the types of pure water and equipment that match their objectives ■ Want to learn about the available pure water production equipment *For more detailed information, please refer to the "PDF Download."

This document is a technical material regarding the purification methods for test water suitable for "Water for Testing Pharmaceuticals" as defined by the Japanese Pharmacopoeia. Using purified water grade water, which was specified as water for pharmaceutical testing in the 15th revision of the Japanese Pharmacopoeia, and ultra-pure water commonly used in HPLC, we conducted an examination of water quality suitable for testing. You can verify the differences in water quality through the data provided. We encourage you to read it. *For more details, please refer to the PDF document or feel free to contact us.

The "Q-Washer" is a cleaning system that combines a cleaning machine with Merck's ultrapure water and pure water equipment. Unlike regenerable SDI, it maintains stable water quality with a continuous ion exchange (EDI) mechanism that does not require regeneration. This reduces cleaning costs and frees you from the hassle of SDI replacement. Additionally, it achieves space-saving and secures new workspaces while also considering fall prevention in its design. 【Features】 ■ Reduction of manual cleaning costs ■ Conservation of cleaning water ■ Automatic determination of cleaning quality based on wastewater conductivity ■ Reduction of operational burden ■ Uniform cleaning & clarity ■ Reduction of contamination due to residues *For more details, please refer to the PDF materials or feel free to contact us.

Mercury is a dangerous chemical substance that has extremely harmful effects on health and the environment, and various regulations have begun in recent years. The regulations regarding the purchase of mercury-containing products differ by affiliated organizations and companies, but a survey conducted by our company in 2020 found that the most common response was "it is necessary to choose products that contain as little mercury as possible," at 47%, while 19% responded that "products containing mercury cannot be purchased," resulting in a total of 66% of organizations having regulations in place. Recently, efforts towards sustainability have been increasingly emphasized. ↓↓ For more details on Merck's mercury-free technology, please see below.

The Milli-Q EQ 7000 is designed for comfortable use and provides strong support for researchers. ● Easy Sampling with Q-POD The sampling speed can be selected from three levels according to the purpose. The Q-POD can be installed in four positions on the main unit (top, bottom, left, right) or placed away from the main unit, making it easy to sample regardless of the installation location. ● Overwhelming Ease of Use Water quality is constantly displayed on the touchscreen, and with just a few clicks, you can print water quality reports or program the volume for quantitative sampling, showcasing its user-friendly design. ● Simple Operation with Touch Panel It can be operated intuitively like a smartphone. All information, including water quality data and maintenance information, is accessible from the touchscreen. You can easily check, save, and retrieve water quality data with simple steps. ● Wide Range of Applications By changing the final filter from the standard Milli-Pak to Biopak, LC-Pak, or EDS-Pak, it accommodates a wide range of applications from equipment analysis to biochemical and molecular biology research. ● Minimization of Maintenance All purification cartridges are designed for easy replacement.

To ensure accurate results, prevent false positives or false negatives, and avoid contamination, it is essential to carefully select reagents containing water when preparing liquid or solid media. Tap water may contain various impurities that can affect bacterial growth or cause errors in the prepared media. Since water is a major component of the media, the removal of these contaminants from water is crucial for media preparation. The recommended water quality for media preparation is detailed in ISO 11133:2014 ("Microbiology of food, animal feed and water — Preparation, production, storage and performance testing of culture media"). Additionally, ANNEX H discusses troubleshooting for media, citing the use of inappropriate quality of pure water as a cause of incorrect pH, color anomalies, formation of precipitates, and culture inhibition. This technical document explains the ISO 11133 standards and Merck's pure water production systems that meet these criteria.

Merck has a wealth of expertise not only in ultrapure water systems but also in pure water. This document includes fundamental knowledge about "distillers," which we often hear requests for, as well as three case studies covering running costs and the causes and countermeasures for silica. You may find hints to solve your problems. 【Examples included】 - Key points and basic knowledge for producing distilled water - Silica, the nemesis of water treatment systems - Which is more cost-effective: running costs of distilled water or pure water (Elix water)? In addition to the above, we provide useful information related to distillers. Please check it out via "PDF Download." ★ A special program just for distiller users! – Would you like to reduce your electricity costs? Laboratory budget-saving program! ★ By switching from a distiller, you can reduce your electricity costs to 1/16! - Recommended for those struggling with rising electricity prices - Necessary for those committed to carbon neutrality/environmental efforts For more details, please see the link below. A simulation for reducing electricity costs is also available.

Attention everyone looking for water free of microorganisms! This is a pure water production system designed to control microorganisms using mercury-free UV lamps. You can also find more details on Merck's website. ↓↓ For product details and inquiries for quotes, please contact us below ↓↓

Are you facing any of these issues? - The purity of water is unstable, affecting analysis and experimental results. - There is limited installation space in the lab, making it impossible to place large equipment. - Filter replacement and equipment management are complicated, leading to a higher chance of mistakes. The completely mercury-free "Ultra-Pure Water/Pure Water System Milli-Q IQ 7003/05/10/15" is designed to minimize stress in the lab with features such as: - "All UV lamps for sterilization, organic matter decomposition, and TOC measurement are mercury-free" - "Eight levels of adjustable water sampling speed" - "The main unit is compact and does not require a specific placement" Additionally, we offer validation support services (IQ/OQ, OQ), calibration services, and USP equipment conformity testing, with many successful adoptions in domestic and international inspections. We will be exhibiting at JASIS 2025. Dates: September 3 (Wed) - September 5 (Fri), 2025 Venue: Makuhari Messe International Exhibition Hall and Conference Center Booth Number: "7A-605" Admission Fee: Free (Pre-registration required) *For more details, please contact us or download the materials.

This is an ultrapure water system designed not only to obtain water quality suitable for its intended use but also to pursue ease of use, featuring technology that is a first in the laboratory market and designed to minimize stress in the lab. Additionally, it offers validation support services (IQ/OQ, OQ), calibration services, and compliance testing for USP equipment, with many successful adoptions in domestic and international inspections. For more details, please refer to our webpage and catalog!

The Milli-Q SQ 2 series is a compact ultrapure water production device with a new concept that allows for the transport and use of a tank. It can provide ultrapure water even in environments without tap water, and it is also possible to add multiple ultrapure water modules. It offers a lineup of four product types to meet the needs of various laboratories.

The Elix Essential pure water system meets water quality and price standards. The standard for future pure water systems! High water quality while being energy-saving and water-saving. Non-heating RO+EDI pure water system. - An easy-to-introduce pure water system at a low price point. - Usable for all pure water applications! - With RO+EDI technology, it can save over 95% energy and over 80% water compared to distillers. - Possible to reduce annual water and utility costs by several hundred thousand yen. - Long-life EDI eliminates the need for regeneration or replacement of ion exchange resins. - Equipped with a new lift-up mechanism for easy maintenance. - Ideal as supply water for equipment requiring pure water, such as cleaners and constant temperature and humidity devices.

Since it uses an easy-to-replace cartridge system, there is no hassle of changing the regenerable ion exchange resin. ↓↓ For catalog requests, please contact us ↓↓

Update to the non-heating pure water production device 'Elix Essential' contributes to ISO 14001 and SDGs! This device uses a RO+EDI method that does not require heat or cooling water, with electricity costs equivalent to about one household fluorescent ceiling light. It is more stable than distilled water, with fewer inorganic ions, organic substances, and microorganisms, making it suitable for various pure water applications. Even if you purchase a new pure water production device, it offers excellent cost-effectiveness, allowing for early recovery of the initial investment. We are currently distributing materials that include cost estimates. 【Features of Elix Essential】 ■ Electricity costs equivalent to about one household fluorescent ceiling light ■ Usable for any pure water application ■ RO+EDI method that does not use heat or cooling water ■ Significant reduction in running costs and removal of silica *For more details, please refer to the PDF document or feel free to contact us.

The "Milli-Q HX 7040 SD" is a pure water production system that can supply multiple accelerated weathering test machines with just one unit. Equipped with a long-life EDI module, it eliminates the costs and hassle of regenerating ion exchange resins, reducing running costs. To consistently remove silica, there are no lamp breakages or heater failures, avoiding sudden repair costs. 【Features】 ■ No scale buildup ■ Easier maintenance for heaters and lamps ■ Consistent removal of silica ■ Significant reduction in unnecessary expenses *For more details, please refer to the PDF document or feel free to contact us.

This catalog is the 2023 edition of the consumables guide for ultrapure water and pure water production systems handled by Merck KGaA. Various cartridges and filters are used in ultrapure water and pure water production systems, and we believe they are being replaced as needed. We hope to provide you with an understanding of the structure and function of the consumables and cartridges for ultrapure water and pure water production systems, as well as the importance of replacing consumables, so that you can utilize higher quality ultrapure water and pure water. [Contents (excerpt)] ■ Why replace consumables? ■ Milli-Q IQ 7003/05/10/15 ■ Milli-Q Integral ■ Milli-Q IQ 7000 ■ Milli-Q Advantage *For more details, please refer to the PDF document or feel free to contact us.

In recent years, the environmental pollution issue caused by PFAS (per- and polyfluoroalkyl substances) has become a concern. To obtain accurate and reliable test results when analyzing PFAS, it is essential that samples are not contaminated with PFAS during the processes of sampling, preparation, and analysis. This webinar will introduce helpful products and information based on data related to the series of PFAS analysis workflows. 【Webinar Date and Time】 August 7, 2024 (Wednesday) 15:00 - 15:45 Free online event 【Recommended for】 - Those involved in PFAS analysis in water utilities, environmental analysis, clinical settings, food and beverage manufacturing, cosmetics, universities, and government agencies - Those considering PFAS analysis in the future 【Main Content】 - Explanation of the PFAS analysis workflow - Key points to watch out for - Introduction of applications such as ultrapure water production systems, sample preparation, and analytical columns Please register and participate using the link below.

We would like to introduce our products, the ICP-MS (ultra-trace element analysis) and the completely mercury-free ultrapure water production system 'Milli-Q IQ 7005/10/15 and Milli-Q IQ 7000 ultra-trace element analysis type' that we handle. In addition to ultrapure water purification in the purification unit of this product, the Milli-Q IQ Element removes ultra-trace metals containing boron to the utmost limit. This reduces the background derived from water, allowing for stable results in ultra-trace element analysis. 【Features】 ■ Designed to match the ultra-trace element analysis workflow ■ Contamination prevention ■ Minimization of maintenance ■ Overwhelming ease of use ■ Easy operation with a touch screen *For more details, please download the PDF or feel free to contact us.

Our company will hold a webinar on the production and management of pharmaceutical testing water, focusing on ultra-pure water and pure water. We will provide specialized knowledge on the standards and purification methods for testing water based on the Japanese Pharmacopoeia, as well as management techniques. Participants will deepen their understanding of specific water quality standards and their impacts, gaining practical knowledge. In particular, we will clearly demonstrate how the quality of testing water contributes to the final quality assurance of pharmaceuticals and provide information that can be useful for your own quality management. [Webinar Overview] ■ Date: June 18, 2025 (Wednesday) ■ Time: 15:00 - 16:00 ■ Registration Deadline: 14:00 on the day of the event *For more details, please check the link below.

Merck KGaA, Life Science will hold webinars in 2025 that incorporate new content. In the webinar "Ultra-Pure Water Production Equipment for PFAS Analysis," we will introduce the characteristics of PFAS and the role of ultra-pure water as blank water in PFAS analysis. In "Pure Water and Its Management for Weather Resistance Testing and Environmental Testing," we will discuss the impact of pure water quality in weather resistance testing. By participating in this webinar, you will gain specific knowledge about the management of testing water, improve the reliability of test results, and strengthen the quality assurance process for pharmaceuticals, among many other benefits. We encourage you to join us. 【Webinar Overview】 ■ Ultra-Pure Water Production Equipment for PFAS Analysis ・Date: August 27, 2025 (Wednesday) ・Time: 15:00 - 16:00 ■ Pure Water and Its Management for Weather Resistance Testing and Environmental Testing ・Date: October 29, 2025 (Wednesday) ・Time: 15:00 - 16:00 *For more details, please download the PDF or feel free to contact us.

Our company will hold a support campaign for the introduction of the small ultrapure water production system 'Milli-Q SQ2 Series' for orders placed from October 1, 2025 (Wednesday) to March 23, 2026 (Monday). This product is a new concept device that can be used by transporting a tank, consisting of two parts: the "RO Water Production Station" that produces pure water (RO water) and the "Ultrapure Water Module." The tank filled with water at the RO Water Production Station is moved to the Ultrapure Water Module, and when the tank of the Ultrapure Water Module is empty, it is moved back to the RO Water Production Station for repeated use. 【Campaign Details】 ■ Period: For orders placed from October 1, 2025 (Wednesday) to March 23, 2026 (Monday) ■ Target Products: Small ultrapure water production system "Milli-Q SQ2 Series" - Separate type: Milli-Q SQ240 - Integrated type: Milli-Q SQ240C - Ultrapure water module: Milli-Q SQ200 *For more details, please download the PDF or feel free to contact us.

Our company will hold a renewal campaign for the pure water production system "Milli-Q" for orders placed from November 4, 2025 (Tuesday) to April 30, 2026 (Thursday). The eligible products include high-end models such as the pure water and ultra-pure water production systems "Milli-Q IQ7003/05/10/15" and "Milli-Q IQ7000," as well as mid-range models like the "IQX System" and "Milli-Q EQ7008." We sincerely look forward to your participation in the campaign. 【Campaign Details】 ■ Period: From November 4, 2025 (Tuesday) to April 30, 2026 (Thursday) for orders ■ Eligibility: Customers from educational and research institutions who own Merck devices (including former Millipore) *For more details, please download the PDF or feel free to contact us.