メルク株式会社ライフサイエンス（シグマ アルドリッチ ジャパン合同会社） List of Products and Services

This product is a calibration mixture consisting of two solutions that facilitate the qualitative and quantitative analysis of extracts and infusions. The components included in the two mixed solutions are selected from a wide spectrum of compound classes relevant to E&L, considering their frequency of detection and toxicity in general E&L testing. Additionally, it is a certified reference material (CRM) manufactured under ISO/IEC 17025 and ISO 17034, which is crucial for ensuring customer reliability. 【Features】 ■ Certification of each component by quantitative NMR ■ Mixed solutions created following the ISO 17034 workflow ■ Testing for homogeneity and long-term stability using GC-MS ■ Traceability to NIST SRM ■ Provision of a comprehensive certificate including uncertainty *For more details, please refer to the PDF document or feel free to contact us.

This document is a guide to HPLC analysis related products for Chinese national standard specifications and Chinese pharmacies that our company handles. It includes HPLC measurements of the pesticide imidacloprid in green tea using the Discovery HS C18 column, HPLC measurements of metoprolol tartrate in extended-release tablets, and HPLC measurements of residual chlormequat in milk. Please take a moment to read it. [Contents] ■ HPLC measurement of the pesticide imidacloprid in green tea using the Discovery HS C18 column ■ HPLC measurement of metoprolol tartrate in extended-release tablets using the Purospher STAR RP-18e column ■ HPLC measurement of residual chlormequat in milk using the Discovery HS C18 column *For more details, please refer to the PDF document or feel free to contact us.

The "Trace CERT Series" is a certified reference material certified by quantitative NMR. Manufactured under the accreditation of ISO/IEC 17025 and ISO 17034. It boasts traceability, calculated uncertainty, lot-specific values, and the highest level of accuracy. Comprehensive documentation in accordance with ISOGuide31 will be provided with the product. 【Features】 ■ Certified reference material certified by quantitative NMR (qNMR) ■ Manufactured under the accreditation of ISO/IEC 17025 and ISO 17034 ■ Traceability, calculated uncertainty, lot-specific values, and the highest level of accuracy ■ Comprehensive documentation in accordance with ISOGuide31 will be provided with the product *For more details, please refer to the PDF materials or feel free to contact us.

This product is a certified reference material (CRM) that combines quantitative NMR and isotope dilution MS for the qualitative and quantitative analysis of toxins, under ISO/IEC 17025 and ISO 17034. Fat-soluble toxins such as okadaic acid and pectenotoxin-11, cyclic imine toxins like gymnodimine and pinnatoxin, as well as new PSTs (such as GTX-6) have been added to the product lineup. We provide comprehensive documentation that includes characteristics, homogeneity, stability, uncertainty, and certified concentration values. 【Features】 ■ Manufactured in facilities accredited to ISO/IEC 17025 and ISO 17034 ■ Certification through quantitative NMR and isotope dilution MS with traceability to NIST or NRC SRM ■ Production of solutions using gravimetric methods ■ Homogeneity and short- and long-term stability testing using LC-MS or LC-IDMS *For more details, please refer to the PDF document or feel free to contact us.

We have partnered with PhytoLab. Their phyproof standard substances are now available worldwide through us, significantly increasing our lineup of standard substances for phytochemistry. The PDF document includes a portion of the list, and more products are expected to be introduced in the future. 【Lineup (excerpt)】 ■Amarogentin ■Anemonin ■Apiin ■Atropine sulfate ■Bacoside A *For more details, please refer to the PDF document or feel free to contact us.

This product is a calibration mixture consisting of two solutions that facilitate the qualitative and quantitative analysis of extracts and infusions. The components included in the two mixed solutions are selected from a wide spectrum of compound classes relevant to E&L, considering their frequency of detection and toxicity in general E&L testing. Additionally, it is a certified reference material (CRM) manufactured under ISO/IEC 17025 and ISO 17034, which is crucial for ensuring customer reliability. 【Features】 ■ Certification of each component by quantitative NMR ■ Mixed solutions created according to ISO 17034 workflow ■ Testing for homogeneity and long-term stability using GC-MS ■ Traceability to NIST SRM ■ Provision of a comprehensive certificate including uncertainty *For more details, please refer to the PDF document or feel free to contact us.

The "Certified Reference Material (CRM) for Elemental Impurity Analysis of Pharmaceuticals" is a mixed solution prepared at concentrations that correspond to the permissible daily exposure (PDE) values outlined in the ICH Q3D guidelines. It ensures the safety of your pharmaceuticals by adhering to the elemental concentration limits for oral, non-oral, and inhalation routes. With the elimination of human preparation errors, it allows for more accurate analysis and reproducibility. 【Features】 ■ Manufactured in facilities accredited to ISO/IEC 17025 and ISO 17034 ■ Improved stability through innovative container design ■ Pre-prepared mixed solution *For more details, please refer to the PDF document or feel free to contact us.

This catalog introduces standard substances for veterinary pharmaceuticals. Starting with "Acepromazine - (Dimethyl-d6) Maleate," it also includes "Carbazole," "Corterol - (tert-Butyl-d9) Acetate," "Corticosterone," "β-Estradiol 17-Acetate," and more. Please take a moment to read it. [Contents (Excerpt)] ■ Acrylamide ■ Iopamidol ■ Equilin ■ Oxacillin Sodium Salt Monohydrate ■ Caspofungin Hydrochloride *For more details, please refer to the PDF document or feel free to contact us.

This catalog provides a detailed list of plant-derived food-based bioactive substances and functional food components, particularly nutrients that demonstrate physiological effects beyond normal nutritional value. It features tools to promote nutrient analysis, including high-purity biochemical substances for in vivo and in vitro research, as well as analytical standards. Please use this for product selection. [Contents] ■ Introduction ■ Plant-derived chemicals ■ Functional food components ■ Products for plant-based research ■ Standard substances for mass spectrometry metabolite library *For more details, please refer to the PDF document or feel free to contact us.

Our company provides pharmaceutical secondary standard substances, available as a convenient and affordable alternative to primary standard substances, for those engaged in the manufacturing and research of pharmaceuticals. By using secondary standard substances, there is no need for you to prepare practical standard substances yourself. Furthermore, our secondary standard substances are offered in larger quantities at lower prices than primary standard substances, allowing you to reduce costs, effort, and time. We currently offer over 700 items of secondary standard substances and will continue to expand our lineup in the future. 【Features】 ■ Traceable to the extent possible to the standards of the United States Pharmacopeia (USP), European Pharmacopoeia (EP), and British Pharmacopoeia (BP) ■ Analyzed using GMP-compliant equipment and pharmacopoeial standards ■ Certified values according to the gravimetric method, in accordance with ISO Guide 34 and ISO 17025 ■ Accompanied by a certificate in accordance with ISO Guide 31 *For more details, please refer to the PDF materials or feel free to contact us.

"Trace CERT(R)" is a certified reference material (CRM) manufactured under dual accreditation of ISO/IEC 17025 and ISO Guide 34. It is traceable to at least two international standards (such as NIST(R), BAM, SI unit kg). It provides a certificate that includes uncertainty and expiration date, created in accordance with ISO Guide 31. Additionally, the certificate for the ICP standard displays measurement results for approximately 70 types of trace impurities. [Features] - Manufactured under dual accreditation of ISO/IEC 17025 and ISO Guide 34 - Traceable to international standards (such as NIST(R), BAM, SI unit kg) - Certificate includes uncertainty and expiration date, created in accordance with ISO Guide 31 - The certificate for the ICP standard displays measurement results for approximately 70 types of trace impurities *For more details, please refer to the PDF document or feel free to contact us.

This catalog features a wide range of "Natural/Phytochemical Standard Substances" handled by Sigma Aldrich Japan. An INDEX is provided for searching in alphabetical order by plant name and substance name, making it easy to identify the corresponding catalog number at a glance. Our company offers standard substances and certified standard substances for active ingredients and markers from medicinal plants. Currently, our product lineup exceeds 600, and we are continuously expanding our new products. New products can be checked on the linked homepage. Please take a look. 【Contents ■ Phytochemical Standard Substances ■ Product List (Plant Name / Alphabetical Order) ■ Standard Substances of Plant Extracts ■ Substance Name: Index (Alphabetical Order) ■ Plant Name: Index (Alphabetical Order) *For more details, please refer to the PDF materials or feel free to contact us.

This catalog features a wide range of "pesticide standard substances" handled by Sigma Aldrich Japan. You can search for product names in alphabetical order from the INDEX, and easily see information such as concentration, CAS number, and desired selling price at a glance. We offer a selection of over 40,000 items, including analytical standard substances and certified reference materials (CRM). [Pesticide Substances (Excerpt)] ■ Aioxynil ■ Sulfur ■ Uniconazole ■ Edifenphos ■ Eugenol *For more details, please refer to the PDF document or feel free to contact us.

We handle "food-derived allergen proteins" from Indoor Biotechnologies. These proteins are purified using either affinity chromatography, HPLC, or both, and their identity and amino acid composition are confirmed by InBioMS (mass spectrometry) and amino acid analysis. Additionally, their immunoreactivity is validated using monoclonal antibodies, and the purified allergens are also verified with IgE antibodies. The purified allergens are processed and validated under a quality management system certified to ISO 9001:2015, ensuring the provision of high-quality and stable allergen proteins. *For more details, please refer to the PDF document or feel free to contact us.*

N-nitrosamines are chemical substances that contain a nitroso group (-N=O). This document introduces the standard substances of nitrosamines that our company handles. Product grades such as "USP standards" from the United States Pharmacopeia and "EP standards" from the European Pharmacopoeia are also listed. According to the International Agency for Research on Cancer (IARC) of the World Health Organization (WHO), many nitrosamines are carcinogenic and genotoxic to animals, and they are considered to have potential carcinogenicity in humans, leading to analysis in various fields. [Contents (excerpt)] ■ N-Nitrosodi-n-butylamine (NDBA) ■ N-Nitrosodiethylamine (NDEA) ■ N-Nitrosodiisopropylamine (DIPNA, NDIPA) ■ N-Nitrosodimethylamine (NDMA) ■ N-Nitrosodi-n-propylamine (NDPA) *For more details, please refer to the PDF document or feel free to contact us.

This document includes standard substances for the analysis of nitrofurans that we handle. Products are introduced by item, such as "Nitrofurazone/SEM," "Fluoroquinolone/AOZ," and "Fluralaner/AMOZ." Nitrofurans are synthetic antibacterial agents and are regulated in Japan as "substances that are not detectable in food as pesticide components," due to their carcinogenic or genotoxic properties, with each of their metabolites being regulated. 【Contents】 ■ Nitrofurazone/SEM ■ Fluoroquinolone/AOZ ■ Fluralaner/AMOZ ■ Nitrofurantoin/AHD ■ Derivatization reagents *For more details, please refer to the PDF document or feel free to contact us.

"Perfluoro and polyfluoroalkyl substances (PFAS)" are artificially created chemicals that have been widely used in industrial products and consumer goods around the world since the 1950s. However, research has shown that they can accumulate in the human body and persist for long periods, potentially causing harmful health effects. As a result, this group of substances is regulated and monitored globally. Our company provides standard materials for both undiluted and solution forms to ensure accurate PFAS analysis. [Product Lineup (Excerpt)] ■Perfluorobutanoic acid ■Perfluoropentanoic acid ■Perfluorohexanoic acid ■Perfluorooctanoic acid *For more details, please refer to the PDF document or feel free to contact us.