メルク株式会社ライフサイエンス（シグマ アルドリッチ ジャパン合同会社） List of Products and Services

High-sensitivity biomarker detection can be achieved in a benchtop size using the conventional sandwich ELISA-based single molecular counting (SMC) technology.

Single Molecule Counting (SMC) immunoassays quantitatively measure target proteins with a wide dynamic range and excellent precision. SMC technology is widely adopted by researchers and pharmaceutical companies around the world to accelerate scientific discoveries and drug development in various disease areas. Our "Custom SMC Services" meet the needs of those who do not have the time or resources to dedicate to assay development for target proteins or measurement of critical samples. 【Possibilities of Custom Services】 ■ Biomarker discovery and development ■ Biopharmaceutical development ■ Reagent selection ■ Sample measurement ■ Development of custom assays *For more details, please refer to the PDF document or feel free to contact us.

This document is the 3rd edition of the Antibody Guidebook. It provides a concise overview of the main features of antibody use and immunochemical techniques in biological research. It clearly explains topics such as "theory of antibodies," "practical use of antibodies," "applications of antibodies," and "examples of protocols" using graphs and illustrations. Please feel free to download and take a look. 【Contents】 ■ Theory of antibodies ■ Practical use of antibodies ■ Applications of antibodies ■ Examples of protocols ■ Appendix ■ Glossary *For more details, please refer to the PDF document or feel free to contact us.

This document introduces our company's "Custom Monoclonal Antibody Production." It includes "Rabbit Recombinant Monoclonal Antibodies," as well as "DNA Immunization Rat and Mouse Monoclonal Antibodies," and "Rat and Mouse Monoclonal Antibodies." We fully transfer the intellectual property and rights of the produced antibodies and provide reliable full support from our technicians. We encourage you to read on. [Contents (partial)] ■ Rabbit Recombinant Monoclonal Antibodies - High-efficiency and high-quality antibody acquisition through Single Cell Picking Technology - Convenient for applications with recombinant antibodies ■ DNA Immunization Rat and Mouse Monoclonal Antibodies - Antibody acquisition for difficult-to-produce membrane proteins and others - Antibodies usable for advanced applications *For more details, please refer to the PDF document or feel free to contact us.

We would like to introduce the "Post-Translational Modification Custom Antibody Production Service" provided by Sigma Aldrich. It is possible to produce antibodies specific to post-translational modifications such as phosphorylation, methylation, and acetylation through our custom services. You can choose from a wide range of services tailored to your needs, including "Rabbit Polyclonal Antibodies," which are all-in-one, hassle-free, and cost-effective, as well as "Rat/Mouse Monoclonal Antibodies" and "Rabbit Monoclonal Antibodies." 【Production Method Line-Up】 ■ Rabbit Polyclonal Antibodies - All-in-one, hassle-free, and cost-effective production ■ Rat/Mouse Monoclonal Antibodies - Antibodies produced through the iliac lymph node method that meet your satisfaction ■ Rabbit Monoclonal Antibodies - Pursuing high quality and excellent consistency *For more details, please refer to the PDF materials or feel free to contact us.

Single Molecule Counting (SMC) immunoassays quantitatively measure target proteins with a wide dynamic range and excellent accuracy. SMC technology is widely adopted by researchers and pharmaceutical companies around the world to accelerate scientific discoveries and drug development in various disease areas. Our "Custom SMC Services" meet the needs of those who do not have the time or resources to dedicate to assay development for target proteins or measurement of critical samples. 【Possibilities of Custom Services】 ■ Biomarker discovery and development ■ Development of biopharmaceuticals ■ Selection of reagents ■ Sample measurement ■ Development of custom assays *For more details, please refer to the PDF document or feel free to contact us.

This catalog introduces the "Immunoassay Platform" that our company handles. It features a "Multiplex Assay System" that can simultaneously measure up to 500 types of proteins with a small amount of sample, as well as a "High-Sensitivity Immunoassay System" and "Immunoassay Analysis Software." Additionally, information about free on-demand webinars is also included. [Contents] ■ Multiplex Assay System ■ High-Sensitivity Immunoassay System ■ Immunoassay Analysis Software ■ Conferma ELISA Kit ■ MILLIPLEX Multiplex Assay Kit ■ Free On-Demand Webinars *For more details, please refer to the PDF document or feel free to contact us.

This document is the first edition of the Inhibitor Handbook. It has been created as a basic guideline for the use of inhibitors in biological research to serve as a reference for your studies. It includes information on "enzyme inhibitors," "receptor agonists & antagonists," and "how to use inhibitors: a technical guide." Please feel free to download and take a look. [Contents] ■ Enzyme Inhibitors ■ Receptor Agonists & Antagonists ■ How to Use Inhibitors: A Technical Guide ■ Glossary *For more details, please refer to the PDF document or feel free to contact us.

The "multiplex assay (simultaneous analysis of multiple items)" is a method that allows for the measurement of numerous samples and multiple proteins at once. With only a small sample volume of 25μL from serum, plasma, or cell culture supernatant, it is possible to rapidly quantify multiple target proteins. Additionally, the xMAP technology utilizes immune reactions to detect up to 500 different types of proteins per well. 【Features】 ■ It is possible to rapidly quantify multiple target proteins with a small sample volume of 25μL from serum, plasma, or cell culture supernatant. ■ It enables the simultaneous measurement of numerous samples and multiple proteins. *For more details, please download the PDF or feel free to contact us.

We would like to introduce our "mPAGE Mini Gel System." This system allows for the simultaneous production of up to two mini gels, enabling electrophoresis with high-resolution precast or hand-cast gels, and provides a leak-free solution for transferring to blotting membranes. The gel size is 8cm x 10cm, with thickness options of 0.75mm, 1.0mm, or 1.5mm, and you can choose between 10-well or 15-well formats for sample loading. 【Features】 ■ Designed for easy leak-free production of mini gels ■ Capable of performing electrophoresis using hand-cast and precast polyacrylamide gels ■ Offers excellent resolution and reduces experimental time *For more details, please download the PDF or feel free to contact us.

This document is a selection guide for budget applications for cell and protein research equipment for the fiscal year 2025. It features a variety of products, including the "xMAP INTELLIFLEX System," which can simultaneously measure up to 500 types of proteins from small sample volumes, and the "SMCxPRO," which achieves biomarker quantification at the femtogram (fg/mL) level. The guide includes photos along with features and system specifications, making it a useful reference when selecting products. We encourage you to take a look. [Contents (partial)] ■ xMAP INTELLIFLEX System ■ Luminex 200 System ■ FLEXMAP 3D System ■ SMCxPRO ■ Auto2D *For more details, please download the PDF or feel free to contact us.