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In a study using a ligament injury model rabbit, improvements in items related to joint stability, such as the elastic modulus, cross-sectional area, and maximum deformation of the knee ligament, were observed in the group that consumed bonito elastin. Elastic modulus = stability Cross-sectional area = thickness Maximum deformation = stretchability The stabilization of ligaments through the intake of bonito elastin is closely related to the stability of the knee joint, and it is expected to help prevent a decline in walking ability in pets and the onset of osteoarthritis in the knee. There are also examples of its use in pet food and pet supplements. *Please feel free to contact us for recommended intake amounts for pets.*

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We would like to introduce the effects of "Hishi extract" on hair. ■ Effects on the Hair Growth Phase Hishi extract may have the potential to decompose and suppress advanced glycation end products (AGEs) that accumulate in the scalp and inhibit hair growth, thereby maintaining a normal hair growth phase. In mouse studies, improvements in hair growth and cuticle conditions were confirmed when diabetic model mice were given the extract. ■ Effects on the Growth Phase Hishi extract has been confirmed to have inhibitory activity against 5α-reductase, which is a cause of androgenetic alopecia (AGA), suggesting it may help maintain normal hair growth. 【Effects on Hair】 ■ Hair growth improvement effects ■ Cuticle improvement effects ■ Hair follicle formation improvement effects *For more details, please refer to the PDF document or feel free to contact us.

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The intake of 75mg/day of bonito-derived elastin has received the following functional claims. ■ Functional Health Claim "It has been reported that bonito-derived elastin peptides help maintain skin elasticity and peripheral blood flow, and protect skin moisture, contributing to skin health." In human clinical trials, improvements in skin elasticity, blood flow, and moisture levels have been confirmed, along with enhanced subjective experiences regarding skin dryness and sagging around the eyes and mouth! Recommended for those concerned about "skin dryness" and "sagging" due to dryness. 【Elastin Functional Effects】 ● Improvement of skin elasticity ● Improvement of skin moisture levels ● Improvement of skin blood flow We also provide support for notifications regarding the above health claims. *For more details, please refer to the PDF document or feel free to contact us.

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The intake of 75mg/day of bonito elastin has received the following functional claims. ■ Functional Health Claims "It has been reported that elastin peptides derived from bonito help maintain the flexibility of blood vessels (the degree of expansion of blood vessels after being constricted), which decreases with aging." "It has been reported that elastin peptides derived from bonito help maintain the elasticity of blood vessels (the degree of expansion of blood vessels after being constricted), which decreases with aging." In human clinical trials, improvements in endothelial function and vascular elasticity have been confirmed, making it recommended for addressing symptoms such as cold extremities and fatigue caused by vascular issues. Furthermore, bonito elastin is the only material that can be labeled as "bonito vascular component." This makes it easy to associate with the image that "because it is a vascular component, it is good for blood vessels!" 【Elastin Functional Effects】 ● Improvement of endothelial function ● Improvement of vascular elasticity We provide support for the notification of the above health claims. *For more details, please refer to the PDF document or feel free to contact us.

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The intake of 75mg/day of bonito-derived elastin has been accepted for the following functional claims. ■ Functional Health Claims "It has been reported that bonito-derived elastin peptides support the movement of healthy middle-aged and older adults who experience discomfort in their knee joints and alleviate discomfort in the knee joints." 【Elastin Functional Effects】 ● Involvement in joint stabilization ● Knee pain reduction effect Due to its knee pain reduction effect, we recommend its inclusion in products aimed at sports and locomotive syndrome. We provide support for the notification of the above health claims. *For more details, please refer to the PDF document or feel free to contact us.

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■Inhibition of AGEs Generation Among 791 types of plant extracts, it has been found that there is a high activity to inhibit the formation of glycation proteins (AGEs), which are the cause of glycation stress. ■Decomposition of Generated AGEs Due to its activity to cleave the characteristic α-dicarbonyl bond of AGEs, it may have the potential to decompose the generated AGEs. ■Suppression of Blood Sugar Levels By inhibiting the activity of α-glucosidase, which is involved in sugar absorption, it has the effect of suppressing the rise in blood sugar levels, potentially preventing hyperglycemic conditions that promote glycation stress. *For more details, please refer to the PDF document or feel free to contact us.*

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We would like to introduce the effects of "Hishi extract" on frequent urination. In the Edo period book "Honchō Shokkan," there is a mention in the section on Hishi stating that it "stops excessive urination (frequent urination due to diabetes, etc.)." The Hishi extract, made from this Hishi, is also expected to have effects on frequent urination. Therefore, we confirmed the effects of Hishi extract on frequent urination through various tests. As a result, it was suggested that Hishi extract has effects on frequent urination through three actions: inhibition of 5α-reductase activity, inhibition of α-glucosidase activity, and antioxidant effects. [Effects on Frequent Urination] ■ Inhibition of prostate enlargement ■ Inhibition of blood sugar level increase ■ Antioxidant effects *For more details, please refer to the PDF document or feel free to contact us.

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We would like to introduce the breath odor prevention effects of Ascofilan HS. The main cause of bad breath is said to be volatile sulfur compounds (VSC). These substances are produced by oral bacteria, and it is also said that factors such as periodontal disease can worsen bad breath. In a study on the intake of supplements containing Ascofilum nodosum, it was confirmed that there is an effect of suppressing the formation of plaque and tartar, which are causes of periodontal disease, as well as an effect of suppressing VSC, the substance responsible for bad breath. [Effects on Bad Breath] ■ Suppression of plaque and tartar formation ■ Suppression of VSC Therefore, it is suggested that Ascofilan HS, made from Ascofilum nodosum, also has breath odor prevention effects. *For more details, please refer to the PDF document or feel free to contact us.

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We conducted anti-pneumonia tests in mice using Ascofillin, cell experiments using HIV, and immune activation tests in humans regarding "Infectious Disease Prevention." The results suggest the potential to prevent infectious diseases such as pneumonia. The activation of immune cells has been confirmed through human trials. 【Overview of Tests and Experiments】 ■ Anti-pneumonia effect: Anti-pneumonia tests in mice ■ Antiviral effect: Cell experiments using HIV ■ Immune activation tests in humans: Immune cell activation effect *For more details, please refer to the PDF document or feel free to contact us.

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We would like to introduce the GLP-1 secretion promoting effect of Ascofilan HS. Ascofilan HS has been confirmed to promote GLP-1 production in the intestines through cell tests. GLP-1 is a hormone produced by intestinal cells that acts on the hypothalamus, stomach, and pancreas, and the following three effects are expected: - Appetite suppression - Prolongation of food retention time in the stomach - Promotion of insulin production From the above, the intake of Ascofilan HS is expected to support weight loss. Additionally, tests using cells and clinical trials in humans have also been conducted. [Cell Tests] - Promotion of GLP-1 production from intestinal-derived cells [Clinical Trials] - Potential to suppress postprandial blood sugar spikes and improve HbA1c levels - Confirmation of weight loss before and after intake in monitoring tests *For more details, please refer to the PDF document or feel free to contact us.

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I will introduce the effects of elastin on blood vessels. Elastin is distributed in tissues that require elasticity and extensibility, with elastin fibers making up about 50% of the aorta. Elastin in blood vessels decreases and ruptures with aging, becoming one of the causes of arteriosclerosis. In human clinical trials, there were improvements in vascular elasticity and endothelial function. [Results of Human Clinical Trials] ■ Vascular elasticity significantly improved ■ Vascular dilation significantly improved *For more details, please refer to the PDF document or feel free to contact us.

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Here is an introduction to the effects of elastin on the lungs. Elastin is an important protein for maintaining the normal function of the lungs, and it makes up about 20% of the elastin fibers in the lungs. The lung structure becomes more fragile with aging, which is closely related to qualitative changes in elastin and collagen, accompanied by a decrease in elastic recoil. As lung function declines, vital capacity and gas exchange ability decrease, leading to shortness of breath and difficulties during exercise. However, tests on human lung fibroblasts using PG showed that bonito elastin has an activating effect on lung cells. 【Cell Test Results】 ■ Maintenance and improvement of exercise performance ■ Activation of lung cells 【Animal Test Results】 ■ Shortened recovery time for blood oxygen saturation after exercise in aging mice ■ Promoting healing effects on lung tissue in lung injury model mice *For more details, please refer to the PDF document or feel free to contact us.

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Here is an introduction to the effects of elastin on the skin. The skin is composed of the epidermis, dermis, and subcutaneous tissue, and elastin in the skin exists in the dermis, bundling collagen fibers to provide elasticity and firmness. However, the amount of elastin in the skin peaks in the 20s and decreases sharply after the 30s. In a double-blind oral intake study of elastin involving 20 Japanese women in their 20s, divided into two groups of 10, it was found that elastin has effects on increasing cheek elasticity and improving crow's feet and overall sensation. [Results of the double-blind oral intake study of elastin] ■ Increase in cheek elasticity ■ Improvement of crow's feet and overall sensation *For more details, please refer to the PDF document or feel free to contact us.

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We would like to introduce the beauty bust effects of elastin. As we age, the Cooper's ligaments stretch, causing the bust to sag. Elastin is a component of these ligaments and provides elasticity. We conducted a human clinical trial focusing on bust sagging during dieting, selecting women with a BMI of 22 to 25 (slightly overweight), as it is believed that the Cooper's ligaments are stretched due to the load from fat. As a result, we confirmed that the suppression of bust sagging and lift-up effects depended on the amount of elastin intake. [Results of the human clinical trial focusing on bust sagging] ■ Lift-up effect confirmed ■ High subjective experience regarding bust droop and firmness was obtained *For more details, please refer to the PDF document or feel free to contact us.

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A study was conducted using a double-blind method on 21 Japanese men and women aged 45 to 75 with self-reported knee joint pain (7 in each group) to examine the effects of an elastin-containing supplement and an elastin plus glucosamine supplement on reducing knee pain. Each day, the elastin group received 75 mg of bonito elastin, while the elastin plus glucosamine group received 75 mg of bonito elastin and 1,000 mg of glucosamine. As a result, effects such as a reduction in knee joint pain and improvement in knee pain were observed. [Double-blind study results] ■ Reduction in knee joint pain ■ Improvement in knee condition *For more details, please refer to the PDF document or feel free to contact us.

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Glycation of LDL has been reported to interfere with the normal metabolism of cholesterol and is involved in thrombus formation, which contributes to the progression of atherosclerosis. When human serum-derived LDL was glycated with glyoxal, the amount of CML produced was measured, and it was confirmed that the addition of Hishi extract inhibited the generation of GML in LDL in a concentration-dependent manner. Additionally, it was confirmed that the addition of Hishi extract promoted cell differentiation and increased the concentration of adiponectin within the cells. 【Glycation of LDL and the Effects of Hishi Extract】 ■ Inhibitory effect of Hishi extract on LDL glycation ■ Reduction of LDL-C through Hishi extract intake *For more details, please refer to the PDF document or feel free to contact us.

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The yellowing caused by glycation leads to a yellowish dullness in the skin. Therefore, we conducted a study on the intake of water chestnut extract, which reduces browning and fluorescence, in relation to glycation levels and skin condition. As a result, significant improvements were observed in skin firmness and elasticity, as well as in skin transparency, suggesting that the intake of water chestnut extract may reduce glycation levels and improve dullness and transparency. [Test Results] ■ The change rate of AGEs sensors significantly decreased. ■ There was a significant improvement in overall facial dullness and transparency. ■ There was a noticeable improvement in skin firmness and elasticity. *For more details, please refer to the PDF document or feel free to contact us.

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"Hishiekisu" is a plant-derived polyphenol carefully selected from 791 samples, possessing high anti-glycation activity and AGE decomposition activity. AGEs (advanced glycation end products) are substances generated in the body when sugars react with proteins, and they are known to be causes of aging and diseases, such as decreased skin elasticity, skin yellowing, and complications of diabetes. 【List of Efficacy】 ■ Improvement of skin yellowing ■ Improvement of skin elasticity and sagging ■ Confirmation of suppression of blood sugar level rise ■ Improvement of lipid metabolism disorders 【Features】 ■ Use of main ingredients with a history of safe consumption ■ Acquisition of abundant efficacy and safety data

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"Ascofilan HS" is a functional food ingredient rich in the seaweed-derived polysaccharide "Ascofilan," which has properties for preventing infections and enhancing immunity. It is extracted from the seaweed Ascophyllum nodosum, which grows naturally along the North Atlantic coast, particularly in Nordic regions. This extract has a low odor, is easily soluble in water, and has low viscosity. 【List of Efficacy】 ■ Improvement of immune function (immunostimulatory effect) ■ Prevention of pneumonia ■ Prevention of viral infections (HIV virus) ■ Suppression of blood sugar level increase (GLP-1) ■ Anti-cancer (anti-tumor) effect 【Features】 ■ Uses raw materials with a history of safe consumption ■ Low odor, easily soluble in water, and low stickiness ■ Abundant efficacy and safety data obtained

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【Functional Display Food Compatible】Marine Elastic Component "Elastin" Elastin is a type of protein that is widely distributed in tissues requiring elasticity, such as skin, blood vessels, and ligaments, and it functions to provide elasticity. 【List of Efficacy】 ■ Improves skin elasticity and sagging ■ Alleviates pain and discomfort in knee joints (ligaments) ■ Improves vascular elasticity ■ Suppresses breast sagging and provides lifting effect ■ Improves lung function 【Features】 ■ Uses main ingredients with a history of consumption ■ Low odor and easily soluble in water ■ Abundant efficacy and safety data obtained

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