ビーエムジー List of Products and Services

"Stem Cell Keep" is a vitrification freezing preservation solution optimized to maintain high vitrification ability while minimizing cytotoxicity, specifically designed for primate ES/iPS cells. Thanks to the high cell protection effect of a novel cryoprotectant with high safety and the ability to maintain a glassy state, it has become possible to freeze and preserve ES/iPS cell colonies more efficiently. 【Features】 - Does not contain DMSO or animal-derived protein components - Allows for freezing preservation of colonies through vitrification - Can freeze and preserve stem cells while maintaining their differentiation potential - Confirmed to be free from contamination by bacteria, fungi, and mycoplasma through sterility testing - Can be stored stably for long periods at 4°C (shelf life of 2 years) *For more details, please refer to the related links or feel free to contact us.

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"Cryoscalis DMSO-Free" is a cell freezing preservation solution that allows for approximately 90% survival rate even after thawing, while maintaining the differentiation potential of stem cells during cryopreservation. It does not contain proteins or DMSO and can be stored stably at 4°C for long periods. Due to the absence of toxicity from DMSO and the influence of proteins, cells can be cryopreserved safely with a high survival rate. 【Features】 ■ Contains no serum or protein components ■ Approximately 90% survival rate even after thawing ■ Stem cells can be cryopreserved while maintaining their differentiation potential ■ Confirmed to be free from bacterial, fungal, and mycoplasma contamination through sterility testing ■ Can be stored stably at 4°C for long periods *For more details, please refer to the related links or feel free to contact us.

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"Seriokeeper" is a DMSO-free preservation solution for skin and nerve tissues that can maintain the membrane morphology of physically fragile tissues and retain proliferation functions for 1 to 2 weeks under refrigeration. It is applicable not only to humans, mice, and rats but also to a wide range of mammalian tissues. In an unopened (pre-preparation) state, it can be stored at 4°C for about one year. 【Features】 - Preserves thin and fragile tissues due to the protective effect of green tea polyphenols. - Usable for epithelial and endothelial tissues, as well as nerve tissues. - Preserved tissues can be used for various experiments with appropriate media after washing. - Confirmed to be free of bacterial, fungal, and mycoplasma contamination through sterility testing. - In an unopened (pre-preparation) state, it can be stored at 4°C for about one year. *For more details, please refer to the related links or feel free to contact us.

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"Stem Cell Keep" is a vitrification freezing solution for primate ES/iPS cells that allows for the cryopreservation of stem cells while maintaining their pluripotency (undifferentiated state). It is optimized to maintain high vitrification capability while minimizing cytotoxicity. By using the vitrification method, cells can be cryopreserved in their colony form. Additionally, it is a product that does not contain DMSO or animal-derived protein components. 【Features】 ■ Does not contain DMSO or animal-derived protein components ■ Allows for cryopreservation in colony form using the vitrification method ■ Can cryopreserve stem cells while maintaining their pluripotency ■ Efficiently cryopreserves ES/iPS cell colonies ■ When used according to the protocol, it can preserve up to 100 vials *For more details, please refer to the related links or feel free to contact us.

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"BioDegmer Filament" is a 3D printer filament with excellent biocompatibility and biodegradability. It can be used in a wide range of applications in the medical field, such as scaffolds for implants and cell/tissue regeneration. By creating 3D models, it allows for hands-on examination of actual models, which is expected to shorten the time required for strength and precision verification, as well as testing and validation. [Features] - For research and development in the medical field - Filament diameter: 1.75mm - Consultation available for prototyping and evaluation of printed products, structural design, and 3D data creation *For more details, please refer to the materials. Feel free to contact us with any inquiries.

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"Biodegmar" is a medical-grade biodegradable and absorbable polymer that can be processed into a variety of shapes and is used in a wide range of applications in the medical field. Our company leverages over 20 years of experience under a strict manufacturing and quality control system based on the international quality management system ISO13485, which is required for medical devices, to provide a diverse range of high-quality custom-made polymers tailored to our customers' needs. We aim to be the ideal innovative solution provider to contribute to improving our customers' productivity and enhancing patients' quality of life (QOL). [Features] ■ Excellent biocompatibility and biodegradability ■ Flexible processing characteristics ■ Can be processed into various shapes, offering extensive application possibilities ■ Polymers can be polymerized according to requests regarding molecular weight and copolymer composition ratios *For more details, please refer to the PDF document or feel free to contact us.

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Poly-p-dioxanone (PDO) is obtained by using p-dioxanone as a monomer and performing ring-opening polymerization. It is mainly processed into biodegradable sutures and is also used as a raw material for new medical devices. Due to its flexible processing characteristics, it can be shaped into various forms. Our BioDegmer is produced in facilities compliant with ISO 13485, can be processed into a wide variety of shapes, and is used in a broad range of applications in the medical field. 【Features】 - Mainly processed into biodegradable sutures - Flexible processing characteristics - Capable of being shaped into various forms - Properties: crystalline, insoluble (except for low molecular weight variants), flexibility *For more details, please refer to the PDF document or feel free to contact us.

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The "L-lactic acid/ε-caprolactone copolymer (LCL)" is obtained by using L-lactide (the cyclic dimer of lactic acid) and ε-caprolactone as monomers and performing ring-opening polymerization of them. LCL (75:25) is primarily processed into biodegradable sutures and marketed, while LCL (50:50) is used as an artificial dura mater. When used as sutures, the filaments are flexible, allowing even thick filaments to be used as single monofilaments. Our BioDegmer is produced in facilities compliant with ISO 13485, can be processed into a variety of shapes, and is used in a wide range of applications in the medical field. 【Features】 ■ Mainly processed into biodegradable sutures ■ Flexible processing characteristics ■ Capable of being processed into various shapes ■ Properties: Amorphous, flexible *For more details, please refer to the PDF document or feel free to contact us.

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"Poly-DL-lactic acid (PDLLA)" is obtained by using lactide (the cyclic dimer of lactic acid) as a monomer and performing ring-opening polymerization. Unlike crystalline poly-L-lactic acid (PLLA) and poly-D-lactic acid, it has an amorphous structure with L-lactic acid units and D-lactic acid units arranged randomly. It is mainly used for (biodegradable) sutures and stent coatings, and recently, development for new absorbable devices is also underway. 【Features】 ■ Mainly used for sutures and stent coating applications ■ Flexible processing characteristics ■ Capable of being processed into various shapes ■ Properties: Amorphous, transparent *For more details, please refer to the PDF document or feel free to contact us.

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"Poly-D-lactic acid (PDLA)" is obtained by using lactide (the cyclic dimer of lactic acid) as a monomer and performing ring-opening polymerization. It has the same properties and performance as PLLA polymer and can be substituted for PLLA, so it is rarely used alone. When PLLA and stereo complex (scPLA) are formed, phenomena such as an increase in melting point and improvement in mechanical properties occur, leading to ongoing research and development of scPLA. Our BioDegmer is produced in facilities compliant with ISO 13485, can be processed into a wide variety of shapes, and is used in a broad range of applications in the medical field. [Features] ■ Has the same properties and performance as PLLA polymer ■ Flexible processing characteristics ■ Capable of being processed into various shapes ■ Properties: Crystallinity, transparency, heat resistance (when stereo complexed) *For more details, please refer to the PDF document or feel free to contact us.

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Poly-L-lactic acid (PLLA) is obtained by using lactide (the cyclic dimer of lactic acid) as a monomer and performing ring-opening polymerization. L-lactic acid and D-lactic acid have the same chemical properties, differing only in their stereostructure. Therefore, the PLLA polymer and PDLA polymer differ only in their stereostructure, with their properties being almost unchanged. However, the PDLLA polymer exhibits different properties due to its molecular chain stereostructure, which is distinct from both PLLA and PDLA polymers. Our BioDegmer is produced in facilities that comply with ISO 13485, can be processed into a wide variety of shapes, and is used in a broad range of applications in the medical field. [Features] - Mainly processed into biodegradable bone fixation materials - Also used as anti-adhesion membranes and stents - Flexible processing characteristics - Capable of being processed into various shapes - Properties: crystalline, transparent, heat-resistant (when stereocomplexed) *For more details, please refer to the PDF document or feel free to contact us.

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The "Glycolic Acid/Lactic Acid Copolymer (PGDLLA)" is obtained by using glycolide (the cyclic dimer of glycolic acid) and lactide (the cyclic dimer of lactic acid) as monomers and polymerizing them through ring-opening polymerization. Lactide can be classified into three types (L-lactide, D-lactide, and DL-lactide) due to its optical activity, so we refer to the copolymer of glycolide and DL-lactide as "PGDLLA." Our BioDegmer is produced in facilities compliant with ISO 13485, can be processed into a wide variety of shapes, and is used in a broad range of applications in the medical field. 【Features】 ■ Obtained through ring-opening polymerization ■ Flexible processing characteristics ■ Capable of being processed into various shapes ■ Properties: Insoluble (high glycolide content) *For more details, please refer to the PDF document or feel free to contact us.

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The "Glycolic Acid/L-Lactic Acid Copolymer (PGLA)" is obtained by using glycolide (the cyclic dimer of glycolic acid) and lactide (the cyclic dimer of lactic acid) as monomers and performing ring-opening polymerization of these compounds. Lactide can be classified into three types (L-lactide, D-lactide, and DL-lactide) due to its optical activity, so we refer to the copolymer of glycolide and L-lactide as "PGLA." Our BioDegmer is produced in facilities compliant with ISO 13485, can be processed into a wide variety of shapes, and is used in a broad range of applications in the medical field. 【Features】 ■ Obtained through ring-opening polymerization ■ Flexible processing characteristics ■ Capable of being processed into various shapes ■ Properties: Insoluble (high glycolide content) *For more details, please refer to the PDF document or feel free to contact us.

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Polyglutamic acid (PGA) is obtained by using glycolide (the cyclic dimer of glycolic acid) as a monomer and performing ring-opening polymerization. Our BioDegmer is produced in facilities compliant with ISO 13485, can be processed into a variety of shapes, and is used in a wide range of applications in the medical field. Its excellent biocompatibility, biodegradability, and flexible processing characteristics make it an ideal innovative solution to contribute to the improvement of patients' quality of life (QOL). [Features] - Can be used as an artificial dura mater reinforcement material, etc. - Flexible processing characteristics - Capable of being processed into various shapes - Properties: crystalline, poorly soluble (excluding low molecular weight variants) *For more details, please refer to the PDF document or feel free to contact us.

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Our company is engaged in the creation of biodegradable bio-medical related instruments and equipment. Biodegradable polymers, such as polylactic acid, are attracting attention as environmentally friendly materials, but issues regarding strength and heat resistance have been pointed out. We have established a new technology that enables radiation sterilization of biodegradable polymer materials, which was previously difficult, and imparts mechanical strength, heat resistance, and durability. Currently, we are working on the development of new applications for biodegradable resins utilizing this technology. 【Features】 ■ Enabled radiation sterilization of biodegradable polymer materials, which was previously difficult ■ Established a new technology that imparts mechanical strength, heat resistance, and durability ■ Developing new applications for biodegradable resins utilizing this technology *For more details, please refer to the PDF document or feel free to contact us.

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Our company is developing next-generation non-clasp denture base materials. When fixing partial dentures or complete dentures in the oral cavity, metal clasps or cast clasps are generally used. However, issues such as aesthetics, damage to the oral cavity and gums caused by the metal tips, and metal allergies have been pointed out. Additionally, since metal comes into contact with the gums, there can be pain and discomfort, leading to a demand for non-clasp denture bases made from materials that cause minimal irritation in the oral cavity. Our company is working on the development of non-clasp denture base materials that excel in aesthetics, fit, and biocompatibility by using acrylic resin, which is widely used as a general denture base material, while also possessing strength and flexibility. 【Features of the developed material】 - Uses acrylic resin, which is widely used as a general denture base material - Excellent in aesthetics, fit, and biocompatibility - Possesses strength and flexibility *For more details, please refer to the PDF document or feel free to contact us.

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Our company is engaged in the development and creation of high-elasticity biodegradable bone fixation materials. To overcome the challenges associated with currently clinically used poly-L-lactic acid (PLLA) bone fixation materials, we are working on the development of bone fixation materials with excellent mechanical strength. The technology under research and development utilizes PLLA as a matrix and employs fibers made into stereo-complex crystals, meeting the mechanical performance required in the early stages of treatment. We are developing materials that more closely approximate the strength characteristics of human bone, contributing to the improvement of patients' quality of life with high-strength, high-elasticity, and high bone affinity biodegradable bone fixation materials. 【Features】 - Engaged in the development of bone fixation materials with excellent mechanical strength. - Utilizes a new composite made from fibers in stereo-complex crystals, meeting the mechanical performance required in the early stages of treatment. - Developing materials that more closely approximate the strength characteristics of human bone. - Biodegradable bone fixation materials that are high-strength, high-elasticity, and have high bone affinity. *For more details, please refer to the PDF document or feel free to contact us.*

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"Acryshot" is a thermoplastic resin for denture bases that has less residual monomer compared to existing heat-polymerized resin denture bases. Since it does not contain bisphenol A in the raw material monomer like sulfonate resins, it has high biocompatibility and, due to the absence of polymerization shrinkage, it achieves good fit. Being an acrylic resin, it allows for repairs using immediate polymerization resin and rebasing with relining materials. 【Features】 ■ Less residual monomer compared to existing heat-polymerized resin denture bases ■ High biocompatibility as it does not contain bisphenol A in the raw material monomer ■ Good fit is achieved due to the absence of polymerization shrinkage ■ As an acrylic resin, it allows for repairs using immediate polymerization resin and rebasing with relining materials ■ Medical device certification number: 21600BZ Z00025000 *For more details, please refer to the PDF document or feel free to contact us.

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Our company is engaged in the development of "medical adhesive LYDEX(R)." LYDEX(R) is based on dextran, a polymer pharmaceutical ingredient with proven safety, and polylysine, a food additive. It consists of aldehyde-modified dextran and succinic anhydride-treated polylysine, each of which is subjected to simple modifications. By mixing these two components in appropriate ratios, we obtain a formulation that exhibits high adhesive performance, sealant effects, and hemostatic effects, which rapidly degrades and disappears in the body after use. 【Features】 ■ Combines strong adhesion with high flexibility ■ Uses raw materials with no risk of infection, ensuring excellent safety ■ A medical adhesive that can be formulated in various forms and used in many fields ■ Research and development of application technologies is primarily advancing in five areas *For more details, please refer to the PDF document or feel free to contact us.

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Our company handles "Absorbable Periodontal Tissue Regeneration Materials (GTR Membranes)." We manufacture membranes (porous films) through a unique production process and supply them to major dental medical device manufacturers. By using this membrane, the regeneration of periodontal connective tissue lost due to periodontal disease is induced. Additionally, this membrane is bioresorbable, eliminating the need for reoperation for removal after healing, making it a patient-friendly and groundbreaking treatment method for periodontal disease (periodontitis). [Features] ■ Membrane (porous film) produced through a unique manufacturing process ■ Induces the regeneration of periodontal connective tissue lost due to periodontal disease ■ Bioresorbable, eliminating the need for reoperation for removal after healing ■ Recognized as a patient-friendly and groundbreaking treatment method for periodontal disease (periodontitis) *For more details, please refer to the PDF document or feel free to contact us.

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Our company has developed a manufacturing technology for artificial joint sliding components with excellent wear resistance by improving the physical properties of ultra-high molecular weight polyethylene through the suppression of free radical generation caused by radiation sterilization. Additionally, we have developed a new technology that dramatically enhances conventional wear resistance by imparting molecular orientation that maximizes the characteristics of polymers. This related patent has been licensed to Biomet, Inc. in the United States, and the company obtained approval from the U.S. FDA in March 2005. We have also begun sales of the second generation of artificial joint products utilizing this technology. 【Features】 - Improved physical properties of ultra-high molecular weight polyethylene - Developed manufacturing technology for artificial joint sliding components with excellent wear resistance - Developed a new technology that dramatically enhances conventional wear resistance by imparting molecular orientation that maximizes the characteristics of polymers - Began sales of the second generation of artificial joint products utilizing this technology *For more details, please refer to the PDF materials or feel free to contact us.

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Our medical-grade biodegradable and absorbable polymers are produced in facilities compliant with ISO 13485 and are supplied worldwide under the brand name "BioDegmer." They can be processed into a wide variety of shapes and are suitable for a broad range of applications in the medical field. Additionally, their excellent biocompatibility, biodegradability, and flexible processing characteristics make them an ideal innovative solution for enhancing patients' quality of life (QOL). We also accommodate small quantity orders for sales. Please feel free to consult us. 【Product Lineup (Excerpt)】 ■ Polyglycolic acid "PGA" ■ Glycolic acid/L-lactic acid copolymer "PGLA" ■ L-lactic acid/ε-caprolactone copolymer "LCL" ■ Poly-L-lactic acid "PLLA" ■ Poly-p-dioxanone "PDO" *For more details, please refer to the PDF materials or feel free to contact us.

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BMJ Corporation is engaged in product development across a wide range of medical fields, including dental-related areas, and operates not only as a raw material supplier but also in the development and manufacturing of products in the medical device sector. In three areas—BioDegmer, New Products, and Research and Development—we support the advancement of technologies in the next generation of regenerative medicine and promote healthy living for people. 【Business Activities】 ■ BioDegmer Area - Research and development and manufacturing of medical biodegradable and absorbable polymers, including polymers for bioabsorbable sutures. ■ New Products Area - Development and manufacturing of products in the medical device sector, including dental-related products. ■ Research and Development Area - Development of cutting-edge medical technologies. *For more details, please refer to the PDF materials or feel free to contact us.

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