東ソー Product Lineup

This data collection introduces analysis examples of the main items for which high-performance liquid chromatography and ion chromatography are used, among the testing methods listed in "Fertilizer Testing Methods (2019)." [Main harmful components and nitrate-reducing agents included in the analysis (excerpt)] ● Sulfamidic acid and ammonium thiocyanate (simultaneous analysis) ● Biuret nitrogen ● Dicyandiamide nitrogen ● 2-Amino-4-chloro-6-methylpyrimidine ● Melamine *For more details, please refer to the PDF document or feel free to contact us.

• Other environmental analysis equipment

■ High-speed analysis column "TSKgel FcR-IIIA-NPR" - Capable of recognizing differences in the N-linked glycan structures of the antibody Fc region and separating antibodies with different ADCC activities. - Liganded with recombinant human Fcγ receptor IIIa, offering improved stability compared to the native type. - Allows for direct separation of antibody samples without the need for purification or pre-treatment. - Separation can be achieved in a short time (20 minutes). (Including equilibration time, measurements can be made in 30 minutes per cycle.) ■ Preparative column "TSKgel FcR-IIIA-5PW" - Demonstrates equivalent separation selectivity as it uses the same ligand as TSKgel FcR-IIIA-NPR. - Capable of loading approximately 5 mg of antibody sample. - Allows for the collection of the amount necessary for structural analysis and activity measurement in a single preparative chromatography run. *For more details, please refer to the PDF document or feel free to contact us.*

• others

This document introduces the high-performance AFC column "TSKgel FcR-IIIA-NPR" handled by Tosoh Corporation. It includes the basic properties of the product, standard separation conditions, application examples, and usage precautions. The new measurement method using this column allows for very simple and quick results with good reproducibility. Additionally, this column can be used not only for quality control of antibody drugs but also for screening production cell lines, optimizing cell culture medium composition, and process analysis of culture processes. 【Contents (partial)】 ■ Introduction ■ Basic Properties - Properties of the packing material - Standard separation conditions - Effects of eluent composition - Effects of sample load amount - Durability - Cleaning methods - Lot-to-lot variation of packing material - Storage stability, etc. *For more details, please refer to the PDF document or feel free to contact us.

• others

"TSKgel Protein A-5PW" is an affinity chromatography column filled with a recombinant Protein A introduced into a porous hydrophilic polymer substrate. The substrate with a particle size of 20μm has high mechanical strength, allowing for high-speed analysis of IgG. It has a high IgG adsorption capacity and a wide quantification range. Additionally, the column material uses PEEK, resulting in low nonspecific adsorption. 【Features】 ■ The substrate with a particle size of 20μm has high mechanical strength, enabling high-speed analysis of IgG. ■ It has a high IgG adsorption capacity and a wide quantification range. ■ Durable column. ■ It has the same ligand as the separation and purification carrier TOYOPEARL AF-rProtein A HC-650F, providing similar separation selectivity. *For more details, please refer to the PDF document or feel free to contact us.

• others

This document is the product catalog for TOYOPEARL and TSKgel series. In "Process Chromatography for Antibodies," we present the characteristics of various chromatography separation modes, as well as key TOYOPEARL products for antibody purification, using tables. Furthermore, the product list categorizes numerous products under each item. [Contents (Excerpt)] <TOYOPEARL> ■ Process Chromatography for Antibodies Characteristics of various chromatography separation modes Key TOYOPEARL products for antibody purification Protein A and Protein L carriers Ion exchange carriers ■ Product List (Process Chromatography) *For more details, please refer to the PDF document or feel free to contact us.

• others

This document is a technical material that explains liquid chromatography. Liquid chromatography has become an essential method for the separation and analysis of biological samples. This guide provides a comprehensive explanation of various separation modes of liquid chromatography, their principles, and features, ranging from the basics to actual measurements. [Contents (excerpt)] - Properties of proteins and nucleic acids - Separation methods for biopolymers - Liquid chromatographs used for measuring biopolymers - Size exclusion chromatography - Ion exchange chromatography *For more details, please refer to the PDF document or feel free to contact us.

• others

The latest column is the UP-SW3000-LS. Please refer to that as well. The "TSKgel UP-SW3000" is a size exclusion chromatography column for the separation of biomacromolecules, using a packing material that chemically bonds diol groups to the surface of silica gel particles with a diameter of 2μm. Due to the fine particle packing material, rapid analysis (15cm column) and high-resolution analysis (30cm) of biomacromolecules such as proteins, antibodies, and enzymes are possible. 【Features】 ■ Enables rapid analysis (15cm column) and high-resolution analysis (30cm) ■ Surface characteristics of the packing material are similar to existing TSKgel SW types ■ Optimized for the separation of antibody (IgG) dimers, monomers, and fragments ■ Compatible with both UHPLC and HPLC systems *For more details, please refer to the PDF document or feel free to contact us.

• others

● The surface properties of the packing material are similar to the existing TSKgel SW type. ● It is suitable for the separation of low molecular weight proteins, fragments, peptides, and oligonucleotides. 【Features】 ■ Rapid analysis (15 cm column) and high-resolution analysis (30 cm) are possible. ■ The surface properties of the packing material are similar to the existing TSKgel SW type. ■ Optimized for the separation of antibody (IgG) dimers, monomers, and fragments. ■ Compatible with both UHPLC and HPLC systems. *For more details, please refer to the PDF document or feel free to contact us.*

• others

"TOYOPEARL AF-rProtein L-650F" is a packing material for protein L immobilized affinity chromatography for the purification of antibodies and fragment antibodies containing light chains. Compared to existing commercial products, the adsorption capacity and alkali resistance have been significantly improved. Additionally, it enables affinity purification of antibodies that do not have an Fc region, which cannot be applied with protein A packing materials. 【Features】 ■ Novel recombinant protein L ligand immobilization ■ Improved adsorption capacity and alkali resistance compared to existing commercial products ■ High mechanical strength ■ Usable at high flow rates ■ Easy to scale up *For more details, please refer to the catalog or feel free to contact us.

• others

This catalog is a comprehensive guide to the hydrophilic polymer packing material "TOYOPEARL," suitable for chromatography from lab scale to production scale. We offer types with average particle diameters of 35μm (some at 30μm), 65μm (some at 75μm), and 100μm, allowing you to use them according to your needs for initial purification, intermediate purification, and high-resolution separation processes. [Contents] ■ Product Overview ■ Size Exclusion Chromatography ■ Ion Exchange Chromatography ■ Hydrophobic Chromatography ■ Mixed-Mode Chromatography ■ Affinity Chromatography ■ Usage and Packing Methods for TOYOPEARL *For more details, please refer to the PDF document or feel free to contact us.

• others

This document is a technical material explaining the TSKgel STAT series columns for high-performance ion exchange chromatography. It introduces the basic characteristics and application examples. [Contents] ■ Introduction ■ Basic properties of the column - Characteristics of the packing material - Column pressure - Separation of standard proteins - Separation of nucleic acids - Sample loading amount ■ Application examples of anion exchange columns ■ Application examples of cation exchange columns ■ Conclusion *For more details, please refer to the PDF document or feel free to contact us.

• others

This document is a technical material explaining the TSKgel Protein C4-300, a high-performance reversed-phase chromatography column for the separation of biomacromolecules. It introduces the basic properties, the impact of measurement conditions on separation, comparisons with other RPC columns, and examples of separations. 【Contents (excerpt)】 ■ Introduction ■ Features ■ Basic Properties ■ Separation Examples ■ Conclusion *For more details, please refer to the PDF document or feel free to contact us.

• others

This document is a technical material explaining the high-performance normal phase chromatography (NPC) / hydrophilic interaction chromatography (HILIC) column TSKgel Amide-80 2μm. We introduce the TSKgel Amide-80 2μm, which improves separation performance compared to the conventional TSKgel Amide-80 by reducing the particle size to 2μm. [Contents (excerpt)] ■ Introduction ■ Features ■ Basic Properties ■ Separation Examples ■ Conclusion *For more details, please refer to the PDF document or feel free to contact us.

• others

The latest column is UP-SW3000-LS. Please refer to that as well. This document is a technical material that explains the high-performance SEC column TSKgel UP-SW3000. We will introduce the basic characteristics and examples of separation. [Contents (excerpt)] ■ Introduction ■ Basic characteristics of TSKgel UP-SW3000 ■ Application examples - Precise analysis of antibody drugs - Separation example of antibody papain digests ■ Conclusion *For more details, please refer to the PDF document or feel free to contact us.

• others

This document is a technical material explaining the high-performance affinity chromatography column TSKgel Protein A-5PW. It introduces basic properties, features, and separation examples. [Contents (excerpt)] ■ Introduction ■ Basic properties ■ Separation examples ・ High-speed analysis ・ Quantification of monoclonal IgG (spike recovery test) ■ Conclusion *For more details, please refer to the PDF document or feel free to contact us.

• others

This document is a technical material that explains the TSKgel ODS-100V 3μm column for reversed-phase chromatography. It introduces the basic characteristics and examples of separation. [Contents] ■ Introduction ■ Basic characteristics of TSKgel ODS-100V 3μm - Characteristics of the packing material - Liquid flow characteristics (H/u curve) - Ionicity - Effects of the mobile phase in LC/MS(/MS) analysis ■ Application examples ■ Conclusion *For more details, please refer to the PDF document or feel free to contact us.

• others

This document is a technical material that explains reverse phase chromatography. High-performance liquid chromatography is a fundamental technique used to separate components in liquids and is utilized in a wide range of fields such as the environment, food, chemistry, and pharmaceuticals. This document focuses on reverse phase chromatography and hydrophilic interaction chromatography, explaining everything from the principles to application examples of high-performance liquid chromatography, which can be considered a classical analytical method. [Contents (excerpt)] ■ What is liquid chromatography? ■ Selection of columns ■ Preparation of elution solutions ■ Setting analytical conditions ■ Sample pretreatment *For more details, please refer to the PDF document or feel free to contact us.

• others

This document contains information on the separation modes of HPLC columns. Liquid chromatography is a separation method that utilizes the difference in the rate of movement caused by the interaction differences between substances and both phases in a stationary field consisting of a packing material (stationary phase) and a moving solvent (mobile phase). In this document, we introduce not only the representative separation modes used in liquid chromatography but also column selection methods categorized by target substances. [Contents (excerpt)] ■ Separation modes ■ Column selection methods by target substances - Low molecular weight organic compounds - Peptides - Proteins - Low molecular weight nucleic acids - High molecular weight nucleic acids *For more details, please refer to the PDF document or feel free to contact us.

• others

The "HLC-8321GPC/HT" is a high-temperature GPC dedicated device designed with a basic concept prioritizing practicality, considering stability, high sensitivity, and fast startup, while also taking into account environmental and safety aspects. It demonstrates its power in analyzing high-temperature soluble samples that are difficult to measure with general-purpose GPC devices. Measurements can be conducted from 40°C in the ambient temperature range to ultra-high temperatures of 220°C. It is compatible with samples that have high dissolution temperatures, including polyethylene, polypropylene, and PPS. 【Features】 ■ Covers ultra-high temperatures (up to 220°C) ■ Stable baseline ■ Fast startup ■ Comprehensive safety mechanisms ■ Excellent operability ■ Compliant with FDA 21 CFR Part 11 *For more details, please refer to the PDF document or feel free to contact us.

• Analytical Equipment and Devices

The "HLC-8420GPC" is an integrated high-speed GPC device equipped with the necessary functional equipment for accurate molecular weight distribution measurement. Each unit, including the delivery pump, degassing section, and column oven, has been completely revamped to achieve excellent stability and reproducibility. By using options such as a solvent stocker and temperature-controlled sampler table unit, it can further enhance baseline stability and accommodate measurements of samples over time. 【Features】 ■ High stability and reproducibility ■ Fast startup ■ High speed, high separation, and solvent-saving ■ Excellent operability ■ Compliance with data integrity, including FDA 21CFR Part 11 *For more details, please refer to the PDF materials or feel free to contact us.

• Analytical Equipment and Devices

This document is a technical material that explains size exclusion chromatography (SEC). We will introduce the basic principles of SEC, measurement methods, and examples of measurements of actual samples. [Contents (excerpt)] - Physical properties and molecular weight of polymers, molecular weight distribution - Measurement methods for average molecular weight and molecular weight distribution - Molecular weight measurement using SEC - Column selection methods - Elution solvents - Sample concentration and injection volume - SEC measurement of super high molecular weight - High-temperature SEC *For more details, please refer to the PDF document or feel free to contact us.

• others

In addition to general-purpose GPC columns, we also introduce specialized SEC columns such as the ultra-fast SEC columns "SuperHZ Series" and "HXL Series," along with guidance on how to differentiate between SEC columns. 【Features】 <SuperMultiporeHZ Series> ■ Pore size-distributed semi-micro SEC column ■ Excellent linearity of calibration curves ■ No inflection points, resulting in undistorted chromatograms ■ Three grades available with different molecular weight fraction ranges *For more details, please refer to the PDF materials or feel free to contact us.

• others

This document is a technical material explaining the TSKgel SuperIC-Anion HR, a high-performance anion analysis column. We will introduce the anion analysis column that has improved separation performance compared to the conventional TSKgel SuperIC series. [Contents (excerpt)] ■ Introduction ■ Product Specifications ■ Basic Properties ■ Analysis Examples ■ Conclusion *For more details, please refer to the PDF document or feel free to contact us.

• others

This document is a technical material explaining the TSKgel SuperIC HS series columns for high-performance ion chromatography. It introduces the basic characteristics of the packing materials and columns, separation characteristics, and application examples. [Contents (excerpt)] ■ Introduction ■ List of column specifications ■ About the anion analysis column "TSKgel SuperIC-Anion HS" ■ About the cation analysis column "TSKgel SuperIC-Cation HS" ■ Conclusion *For more details, please refer to the PDF document or feel free to contact us.

• others

This document contains information on HPLC columns for normal phase chromatography and multi-mode chromatography. In addition to the characteristics of each mode, it introduces the main target substances. Furthermore, it includes charts and tables for separation and comparison. [Contents (excerpt)] ■ Normal Phase Chromatography ■ Multi-Mode Chromatography ■ Columns for LC/MS ■ Reverse Phase Chromatography *For more details, please refer to the PDF document or feel free to contact us.

• others

This document explains ion chromatography of HPLC columns. It provides an explanation of the separation and analysis of both anion analysis columns and cation analysis columns, using diagrams and tables. 【Contents (excerpt)】 ■ Anion analysis column (for IC-2010) ■ Cation analysis column (for IC-2010) ■ Anion analysis column (non-suppressor type) ■ Anion analysis eluent ■ Cation analysis column (non-suppressor type) *For more details, please refer to the PDF document or feel free to contact us.

• others

This document explains size exclusion chromatography (SEC) for HPLC columns. It includes features of SEC columns and a list of compatible H-type solvents. Additionally, the section on SEC column selection provides a detailed explanation of both aqueous SEC column selection (for synthetic polymers) and organic solvent-based SEC column selection, using tables for clarity. 【Contents (excerpt)】 ■ Features of SEC columns ■ List of compatible H-type solvents ■ SEC column selection ■ Aqueous SEC columns (for proteins, peptides, and nucleic acids) ■ Aqueous SEC columns (for synthetic polymers, polysaccharides, oligosaccharides, and nucleic acids) *For more details, please refer to the PDF document or feel free to contact us.

• others

This document explains the IEC, HIC, and affinity of HPLC columns. It introduces the characteristics of ion exchange chromatography columns, as well as basic physical properties. Additionally, it explains each product series using tables. Furthermore, it also includes information on hydrophobic chromatography and affinity chromatography. 【Contents (excerpt)】 ■ Ion Exchange Chromatography ■ Hydrophobic Chromatography ■ Affinity Chromatography *For more details, please refer to the PDF document or feel free to contact us.

• others

"TSKgel Protein C4-300" is a reverse phase chromatography column for the separation of biomacromolecules, using a packing material with silica gel of particle size 3μm and pore size 30nm, with butyl groups (C4) immobilized. It exhibits strong protein retention and excellent separation selectivity. 【Features】 ■ Strong protein retention and excellent separation selectivity ■ High recovery rate for general water-soluble proteins, with superior peak shape ■ Due to the use of fine particle packing material (3μm), it enables high throughput, high separation, and high sensitivity measurements ■ The 2mm inner diameter column is suitable for LC/MS (/MS) measurements *For more details, please refer to the PDF document or feel free to contact us.

• others