信州ＴＬＯ Product Lineup

The present invention is a chemical synthesis technology for proanthocyanidins, specifically "epigallocatechin oligomers." Proanthocyanidins, "epigallocatechin oligomers," are a type of polyphenol that is expected to have metastasis-inhibiting effects on cancer cells, and there are expectations for the development of functional foods that have never been seen before, as well as their use as reagents.

• Organic Natural Materials

Fusicoccin, a diterpene glycoside isolated as a metabolic product of fungi that parasitize trees such as almonds, has been reported to irreversibly open plant stomata and induce continuous transpiration, leading to the death of the plant. In this invention, it has been revealed that under sufficient light and water supply, fusicoccin functions as a plant growth enhancer.

• others

Traditionally, methods for producing graphene have involved vapor-phase methods or exfoliation methods. Vapor-phase methods can produce highly crystalline graphene, but they have the challenge of high costs, while exfoliation methods are low-cost but result in graphene with low crystallinity. This technology involves a method for uniformly dispersing partially oxidized graphene with low oxygen content in a hydrophobic ionic liquid through the electrochemical exfoliation of graphite in a water-hydrophobic ionic liquid two-phase system. 【Features of the Technology】 - Two-phase system (water-hydrophobic ionic liquid) electrochemical exfoliation method - Surface oxygen concentration below 10%, eliminating the need for re-reduction treatment - Control of surface oxygen concentration is possible A wide range of materials can be applied to the graphite electrodes, and by exploring ways to reuse the ionic liquid, significant reductions in manufacturing costs are expected.

• Composite Materials

Introducing the "Electret Capacitor Sensor (ECS)." It is possible to manufacture thin and flexible electret capacitors using silica aggregate electrets. Even in contact with the target object, it can measure acoustic and ultrasonic waves, making it applicable for monitoring plant activities and bioacoustic sensing. 【Technical Features】 - Capable of wideband sensing (from below 1 Hz to above 200 kHz) - Pressure resistance, heat resistance, and moisture resistance - Suitable for air, biological systems, soft materials, and can also be applied underwater - Thin and flexible

• Other measurement, recording and measuring instruments

I would like to introduce "water-soluble porphyrin derivatives." Porphyrins are used in photodynamic diagnosis (PDD) and photodynamic therapy (PDT) for cancer diseases; however, porphyrins typically lack water solubility and biocompatibility, and they require time for metabolism. This technology allows for the synthesis of water-soluble porphyrin derivatives by combining porphyrins with sugar chains that exhibit excellent water solubility and biocompatibility. 【Features of the technology】 - Water solubility - Biocompatibility - Polymer derivatives (can be processed into films)

• Other polymer materials

Introducing the "Ultrasonic Pump." Conventional ultrasonic pumps have complex structures and are expensive. This technology features a very simple structure, making it possible to use in environments where it was previously difficult, as well as achieving compactness and low cost. ■ Features 〇 Simple Structure - Composed of three parts: ultrasonic vibration section, flow path parts (horn section), and opposing parts, resulting in a simple structure. - Miniaturization is also possible. 〇 No sliding or rotating parts like pistons or valves - No wear or damage. - Maintenance is easy. 〇 Usable over a wide temperature range - Does not use materials like rubber, allowing for a wide selection of materials. - Operates down to ultra-low temperatures like liquid nitrogen. - High-temperature range up to the operating range of the ultrasonic transducer (Curie temperature). - Depending on material selection, usage in strong magnetic fields is also possible. *For more details, please refer to the PDF document or feel free to contact us.

• others

Introducing a technology for the simple and highly accurate quantification of surface charge sites in nanomaterials. Conventional surface charge site quantification techniques have faced challenges such as being time-consuming and labor-intensive, and the high cost of automatic titration devices. In this technology, the sample size is extremely small compared to titration methods, and it can be executed using only highly versatile equipment. Additionally, it allows for rapid (within 2 hours) and simple operations, achieving measurement accuracy comparable to titration methods. **Features** - The sample size is extremely small compared to titration methods (0.5 to 2.5 mg per run). - Can be executed using only highly versatile equipment (centrifuge and visible light spectrophotometer). - Allows for rapid (within 2 hours) and simple operations, achieving measurement accuracy comparable to titration methods. - Enables individual quantification of strong acidic sites (sulfuric ester groups) and weak acidic sites (carboxyl groups). - Dye adsorption is completed in 2 hours. *For more details, please refer to the PDF document or feel free to contact us.*

• others

Introducing the creation of hydrogel fibers using microchannels. This technology allows for a gentle progression of the gelation reaction within a microchannel with a flow-focusing structure, making shape control easy. It enables the precise fabrication of single-strand hydrogel fibers (approximately 100μm in thickness). Additionally, scaling up through parallelization is also achievable. 【Features】 ■ Easy shape control ■ Gentle progression of the gelation reaction within a microchannel with a flow-focusing structure *For more details, please refer to the PDF document or feel free to contact us.

• others

We will introduce the technology for directly cultivating clay nanosheets with excellent adsorption properties using silica gel. Cation exchange materials are utilized by being packed into columns or dispersed in water, but in the latter case, it is important that the adsorbent can be easily recovered. In conventional technologies, recovery through filtration or centrifugation can be difficult when dealing with fine particles (at the nanoscale). In this technology, the material hardly delaminates even in solvents that typically cause swelling and delamination, making recovery from the solution easy. Since it thinly coats the silica surface, it is useful for separation in distribution systems. 【Features】 - Hardly delaminates even in solvents that cause swelling and delamination - Easy recovery from the solution - Thinly coats the silica surface, aiding in separation in distribution systems - Not dependent on the shape of the starting silica *For more details, please refer to the PDF document or feel free to contact us.

• others

We will introduce a translucent electrode made of photocatalytic powder and a "water-splitting tandem cell" using it. By using titania nanosheets as both an anchor and conductive layer for the powder, we have developed a novel method to create a translucent photoanode from photocatalytic powder materials. By using this translucent powder photoanode as the top cell and a powder photocathode for hydrogen generation as the bottom cell, we enable the construction of a powder material-based tandem cell capable of complete water splitting under sunlight irradiation. 【Features】 ■ Tandem structure ■ Reaction driven in a self-sustained state without wiring ■ No need for product separation ■ Steam splitting (potential use of seawater) ■ Useful energy carrier *For more details, please refer to the PDF document or feel free to contact us.

• others

We will introduce researchers and technological seeds suitable for your company's product/technology development/research. Since our establishment, we have supported the commercialization of various companies. We have extensive experience and achievements in commercializing technologies developed at universities and launching new businesses utilizing subsidies. Please feel free to contact us. ■ Technology Transfer Services - Introduction of researchers and technical information (such as patents) - Coordination of technical guidance by researchers - Mediation of joint research and commissioned research - Support for obtaining patents and rights ■ Commercialization Support Services - Mediation and contracting of grant projects - Implementation of lectures and basic courses - Support for interaction between companies and researchers

• Other services