信州ＴＬＯ List of Products and Services

Oligo DNA derived from the genomic sequences of beneficial microorganisms such as lactic acid bacteria forms a characteristic three-dimensional structure and functions as an aptamer that binds to target proteins. Muscle-forming type oligo DNA promotes muscle differentiation, enhances cardiomyocyte differentiation, and suppresses adipocyte differentiation, while bone-forming type oligo DNA promotes the differentiation of osteoblasts.

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This technology provides excellent functionality of the compound Chol-U-Pr-mPEG, which has a steroid group as the hydrophobic part and includes PEG as the hydrophilic part. The cholesteryl group is hydrophobic and can be coated onto the surfaces of hydrophobic resin materials such as polypropylene and polystyrene, which are widely used in medical materials, using the Grafting-to method. It is also known that among proteins, it suppresses the adhesion of platelets, making it expected to be utilized as an antithrombotic coating in circuits such as ECMO and artificial dialysis devices. 【Advantages】 ■ Reduction of chemical modification processes and labor ■ No residual by-products ■ Significantly suppresses protein (globulin) adsorption compared to PEG *For more details, please refer to the PDF document or feel free to contact us.

• Coating Agent

This is an innovative reverse osmosis membrane and spacer (RO membrane module flow channel material) that combines CNTs, which have antifouling properties, and CNFs, which have high permeability, to provide performance tailored to various applications. One type of this module, the "ultra-low pressure high permeability CNF/PA composite reverse osmosis (RO) membrane," has obtained the "ANSI58" certification from NSF (National Sanitation Foundation), a certification standard for water purification membranes in the United States. This is the first certification obtained in Japan, and it is expected to be applied to "purified water" water servers and other products, which are rapidly gaining demand, especially in developing countries.

• Pure water production equipment

In traditional taste evaluation methods, there were the following issues: - The relationship with overall deliciousness is unclear. - Deliciousness cannot be directly evaluated. This technology allows for the judgment and prediction of deliciousness with a focus on texture. (Features of the technology) - "Quantification of deliciousness" using a database that incorporates sensory evaluations (taste and texture). - The only measurement required for evaluation is "pressure distribution." - Construction of a database tailored to specific foods. (Expected applications) - Expansion into new foods such as cultured meat. - Development as a sales standard for agricultural products. - Application in quality control and product development. You can check the introduction materials for the Food Visualization Project (Utsunomiya University Robotics and Agricultural Technology Research Institute) at the related links below.

• Food Testing/Analysis/Measuring Equipment

Image recognition device and image recognition program It is possible to provide high recognition accuracy regardless of the resolution of the inspection images. Teacher data generation device, teacher data generation program It is possible to efficiently and easily execute the generation of teacher data. (Expected applications) - Support for exploring lesions in endoscopic images - Construction of a cancer cell image database - Development of a cytology screening system - Development of anomaly detection systems using image data from various fields

• Image analysis software

★Iron-based Plating Electrode★ - This is a technology for "platinum alternative materials" that achieves high cost performance. (Application) Alkaline water electrolysis devices / Hydrogen production ★Efficient Control of Enzymatic Browning (Water-soluble Tyrosinase Inhibitor)★ - This leads to prevention of skin photoaging, suppression of food browning, and prevention of microbial infections. (Application) Functional cosmetics, food browning inhibitors ★Power Circuit Breaker that Instantly Limits Overcurrent★ - It automatically enters current limiting and tripping operations while minimizing overcurrent, completing the trip in a short time. (Application) Power distribution systems, electric vehicles, data centers, etc. ★Evaluation Method for "Deformation Characteristics and Stability" of Rock Structures★ - Essential evaluations for rock structures can be assessed through "deformation anisotropy" and "simple shear." (Application) Foundation work, seismic design, maintenance management ★High-Efficiency Buck DC-DC Converter★ - Improved load response of existing buck DC-DC converters, increasing efficiency for high buck and large current applications. (Application) Many-core processors, non-volatile memory storage, etc. ★Photocatalysts and Photoelectrodes for Water Splitting★ - This is a technology for photocatalysts aimed at achieving high efficiency in "artificial photosynthesis." (Application) High-efficiency solar hydrogen production, decomposition of organic substances.

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A buck power supply circuit that improves the load response of existing buck DC-DC converters, enhances efficiency for high step-down and large current applications, and increases stability.

• power supply

Tyrosinase is an enzyme involved in pigmentation phenomena in nature. Inhibiting this enzyme can lead to prevention of skin photoaging, suppression of food browning, and prevention of microbial infections. In this technology, we have successfully developed a "new resorcinol derivative" that shows approximately 30 times stronger activity compared to the commercially available tyrosinase inhibitor, kojic acid. - Approximately 30 times the tyrosinase inhibitory activity compared to the commercially available tyrosinase inhibitor (kojic acid) - Possesses water-soluble properties with glycosides incorporating sugar chains such as glucose - Inhibitory activity can be adjusted by varying the length of the alkyl chain

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【Deformation Anisotropy】 "Method for identifying the orthotropic elastic properties of rock masses through uniaxial testing" - Can identify three principal axes + 9 parameters (not possible with conventional techniques) - Significantly fewer tests required (3 cylindrical specimens) - Applicable to prismatic specimens as well - Low cost, high precision 【Simple Shear】 "Simple shear testing of rock prismatic specimens using torsion" - The only testing method available in the country - Clarifies the deformation characteristics of rocks during earthquakes - Obtains data necessary for seismic design - Evaluation of repeated "shear" - Traffic loads from vehicles and trains - Foundations of offshore wind power affected by wave action

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This technology is a power circuit breaker that adopts a completely new operating principle, not an extension of conventional technology. By highly integrating fuses and semiconductor switches, it enables the realization of a "next-generation circuit breaker" that can instantly limit overcurrent. - It can reliably prevent and completely interrupt abnormal large currents every time. - It allows for instant current limiting and interruption (AC, DC, overcurrent). - High-speed re-energization is possible. - High versatility (operating voltage 0.1 to 10 kV). - Due to high design flexibility, optimization for specific applications is easy. Comparison with existing circuit breakers for railways: - Interrupt time (approximately 40% reduction). - Device size (approximately 95% miniaturization). - Price (approximately 90% reduction). By dramatically reducing the risk of electrical equipment failure and improving current resistance, benefits such as miniaturization and cost reduction of electrical systems can be anticipated.

• Circuit breakers and switches

★Variable Flux Motor★ - A highly efficient motor in high-speed regions. (Application) Applicable to inverter-equipped motors such as refrigerators, air conditioners, and main motors for EVs. ★Expandable Panel Unit★ - A panel unit with a scissor structure that can expand and contract both vertically and horizontally. (Application) Emergency temporary bridges (alternative routes for roads or bridges damaged by disasters). ★Gently grasp and rotate! A "Soft Robot" useful for agriculture★ - Enables rotation and movement while holding an object due to internal expansion and contraction. (Application) For harvesting vegetables and fruits. ★Storage method for arbuscular mycorrhizal fungi★ - Refrigerated storage of pure cultured mycorrhizal fungi is made possible by adding fatty acids to the culture medium. (Application) Aids in "quality stabilization" following mass production of microbial materials. ★Wet Bulb Globe Temperature (WBGT) Meter (Easily measures heat stress and thermal environments)★ - Capable of measuring wet bulb globe temperature (WBGT) despite its simple structure. (Application) Easily utilized for heat stress prevention by understanding WBGT. ★Plant growth regulator using the stomatal opening effect of Fusicoccin★ - Fusicoccin can be utilized as a plant production enhancer. (Application) Production enhancer for crops and growth management in hydroponics.

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The representative arbuscular mycorrhizal fungi coexist with the roots of various crops, absorbing nutrients (especially phosphorus) from the soil and supplying them to the crops. Therefore, they are utilized as environmentally friendly microbial materials to reduce phosphorus fertilizer usage. The current materials are obtained through "co-cultivation," but there are challenges remaining in mass production and quality stabilization, leading to considerations for materialization through "pure culture." Our group has discovered an efficient pure culture method by adding fatty acids such as myristic acid to the medium during the cultivation of parent spores. However, since the microbial materials obtained from pure cultures are stored in refrigeration until they are used in the field, we are investigating production conditions for next-generation spores that can maintain sufficient germination rates even after refrigeration. By adding not only myristic acid but also palmitic acid to the medium, we can approach the germination rates achieved in co-cultivation, which will contribute to the "quality stabilization" following the mass production of microbial materials. [Summary] - Established an efficient pure culture method for mycorrhizal fungi by adding fatty acids to the medium. - Further innovations in the fatty acids added to the medium will lead to the materialization of spores suitable for refrigeration storage. - Technical guidance for materialization towards the unique strains held by various companies, rather than a monopoly on technology by a single company, is possible.

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At the Shinshu University Faculty of Engineering, the Arai-Shimizu Laboratory develops unique technologies, including "CNT composite plating technology," which creates plating films composed of carbon nanotubes and metals, and "roughening plating treatment," which enhances adhesion between steel and resin. If you are interested in collaborative research aimed at practical application, please feel free to contact us. 【Research Content】 ■ CNT Composite Plating Technology - Creation of plating films composed of carbon nanotubes and metals - Considering use as an electron emission source for displays ■ Roughening Plating Treatment - Achieving bonding and adhesion enhancement between dissimilar materials (steel/resin) 【Keywords】 Lithium-ion battery materials, storage battery materials, bonding of dissimilar materials (metal and resin), display materials, wear-resistant materials, high thermal conductivity materials, etc. *For more details, please refer to the PDF document or feel free to contact us.

• Other services

★Sugar-derived aldehyde compounds★ - Aldehyde compounds obtained by oxidizing sugars (Application) All fields that use volatile aldehyde compounds ★Curved surface robot that can control shape★ - A device/product with a curved surface that can control its shape according to the individual user or scene! (Application) Support system for laparoscopic surgery ★Foldable emergency temporary bridge★ - A panel unit with a scissor structure that can expand and contract both vertically and horizontally. (Application) Emergency temporary bridge (alternative route for roads or bridges damaged by disasters) ★Multipoint pulse wave measurement system using photoelectric volumetric pulse wave sensor★ - Health management technology for estimating blood pressure with low error using photoelectric volumetric pulse wave (PPG) (Application) Continuous blood pressure monitoring in daily life using wearable devices ★Ultrasonic pump without valves or sliding parts★ - A pump with a very simple structure that can operate in harsh environments due to the absence of valves or sliding parts (Application) Pumps for special conditions such as high temperature, low temperature, and strong magnetic fields

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We introduce a method for estimating blood pressure using photoplethysmography and a computer program for blood pressure estimation. In the conventional method of estimating blood pressure using photoplethysmography, there were significant estimation errors due to individual differences and issues related to the black-box nature of nonlinear models, which prevented widespread use. This technology alleviates estimation errors caused by individual differences by introducing normalization of features and bias adjustment for blood pressure, thereby generating a generalized model. To address the black-box issue of nonlinear models, we utilized a multiple regression model to facilitate the interpretation of the blood pressure estimation model. As a result, depending on the training data, it has become possible to construct a generalized blood pressure estimation model with an estimation error of 10 mmHg or less. [Keywords] Health management / Wearable devices / Medical devices / Machine learning / Work style reform *For more details, please refer to the PDF document or feel free to contact us.

• Other electronic measuring instruments

As a surface-shaped device or product that can control its form according to the user's personal preferences or the scene, examples include deformable clothing, fabric products, architecture, and Virtual Reality products. The potential of "shape-integrating devices" is being explored as the next innovation that will transform daily life after the widespread adoption of smartphones. This technology is: ◆ A surface version of the piecewise constant curvature model of a curved shape manipulator (a commonly used model). ◆ Instead of specifying the positions of control points like in NURBS, it adopts a method of specifying the curvature and elongation of actuators. This is suitable for controlling robots.

• Other industrial robots

★Quality Control of Nanocellulose★ - A technology for conveniently and accurately quantifying surface charge groups of nanomaterials (Application) Measurement of surface charge groups of nanocellulose ★Foldable Emergency Temporary Bridge★ - A panel unit with a scissor structure that can expand and contract both vertically and horizontally! A technology applicable from rapid disaster recovery to space development. (Application) Emergency temporary bridge (alternative routes for roads or bridges affected by disasters) Temporary equipment (scaffolding), gangways, etc. Space structures (space-saving storage areas) ★Safe Water for People Around the World★ - Technology for producing water treatment membranes (polymer grafting via ATRP) (Application) Water quality management ★Reduction of Manufacturing Costs for Biosensors★ - Flow path mechanism for sensors (Application) Biosensors, biological measurements, environmental measurement devices, etc. ★Reducing Environmental Impact Without Emulsifiers★ - Emulsification technology that does not use surfactants (Application) Emulsifier-free cosmetics, pharmaceuticals, food ★High-Speed! High-Resolution! Wide-Range! Surface Inspection Device★ - Surface shape measurement using optical combs (Application) Inline full inspection, surface inspection, film and sheet inspection, etc.

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We have achieved the advancement of non-destructive internal inspection of concrete structures using microwave radar. The aging of social infrastructure is becoming a serious social issue, with many problems related to the safety and security of concrete structures, such as the health diagnosis of tunnels and bridges, seismic performance evaluation of concrete buildings, and deterioration inspection of rebar and piping within concrete. While construction technology for concrete structures has made remarkable progress, effective diagnostic techniques for their maintenance have not yet been found. This technology achieves high precision in radar imaging (position and shape estimation) and improved estimation performance of embedded material properties (such as material type and degree of deterioration) through the advancement of microwave propagation time estimation and the refinement of microwave propagation and reflection models.

• X-ray inspection equipment

We would like to introduce university technology seeds related to measurement and metrology. Please feel free to visit our booth (No. I-63). －★Environmental Related★－ ○ Underwater Fluoride Concentration Measurement Kit (Shinshu University) It enables the measurement of fluoride ion concentration using visible light! ○ pH Sensor Film (Tokyo Denki University) This is a manufacturing technology for pH indicator materials that do not leach dye! Various applications related to pH measurement are expected. －★Nanomaterials Related★－ ○ Surface Charge Base Quantification Kit (Shinshu University) This technology allows for simple and highly accurate quantification of the surface charge base of nanomaterials! －★Non-Destructive Testing Related★－ ○ Concrete Structure Inspection using Microwave Radar (Shinshu University) This is a measurement technology for the safety and security of society! It is a non-destructive testing technology for concrete structures, such as aging social infrastructure, which are becoming a concern. It has realized advanced non-destructive internal inspection of concrete structures using microwave radar. ○ Surface Shape Measurement using Optical Combs (Saitama University) This technology achieves extensive and high-speed surface defect detection! The development of inspection devices capable of simultaneously measuring optical properties such as reflectivity is expected.

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This is a panel unit with a scissor structure designed for high intensity and long spans. This panel unit is foldable and can achieve length adjustment by combining units, making it suitable for applications in highly mobile emergency temporary bridges and space structures. Given the recent frequent collapses of bridges due to heavy rain disasters, we encourage you to consider utilizing this technology.

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This technology achieves emulsification using ultrasound without the use of surfactants. Generally, to emulsify a mixture of water and oil that has separated into two layers, amphiphilic substances such as surfactants are used in combination with physical methods like homogenizers and mixers, and the resulting emulsified products are provided. On the other hand, surfactants impose a burden on the environment, and in recent years, there has been a growing demand for emulsified products that not only reduce the amount of surfactants used but also do not use surfactants at all. This technology not only reduces the environmental burden by not using surfactants but also has the potential to create emulsified products that have never been seen before.

• Emulsifier/Disperser

To understand thermal (heat) environments, the Wet Bulb Black Globe Temperature (WBGT) is used, which is calculated from the temperature of a device called a black globe. However, since it is a specialized device and not easy to handle, it has not been widely adopted. This technology allows for the measurement of Wet Bulb Black Globe Temperature (WBGT) despite its simple configuration. Additionally, it can be easily used by anyone, making it straightforward to utilize for the prevention of heat-related illnesses by understanding WBGT. 【Features of the Technology】 - No need for specialized black globe thermometers or difficult-to-handle wet bulb thermometers (can be created using commercially available components) - Direct reading of thermal (heat) environments - Stationary and all-weather type - No prediction errors due to installation methods - Provides data more reflective of reality in the morning and evening compared to black globe wet bulb temperature (WBGT) This technology is expected to lead to the development of a "wet black globe water thermometer" that allows anyone to accurately, easily, and affordably understand thermal environments. We are looking for "users willing to try it out" and "manufacturers considering commercialization."

• Other environmental analysis equipment

In manufacturing production lines, it is necessary to detect surface and coating defects in all individual items. However, conventional inspection devices have faced challenges in achieving extensive and high-speed high-resolution sampling measurements. This technology realizes extensive and high-speed measurement of three-dimensional surface structures through optical frequency comb (optical comb) single-shot tomographic imaging technology. 【Features of the Technology】 - The optical comb enables measurement of three-dimensional structures over a wide area and at high speed. - The optical comb allows for non-contact measurement of object shapes. - It is possible to simultaneously measure attribute information of the measurement target (such as refractive index, transmittance, reflectance, etc.). - High-speed one-dimensional scanning is unnecessary, making it resistant to vibrations. 【Verification Examples in the Laboratory】 - Verification of surface structure measurements using various materials. - Measurement of two-dimensional cross-sectional images (in the depth direction) of laminated materials and compositional analysis, etc. This technology is expected to lead to the development of inspection devices capable of extensive and high-speed surface defect detection while simultaneously measuring optical properties such as reflectance.

• Defect Inspection Equipment

Conventional pH measurement methods (litmus paper, glass electrode meters) have the issue of internal reagents leaching into the measurement solution. This technology has achieved a pH indicator copolymer that does not leach into the measurement solution by polymerizing pH dyes. 【Features of the Technology】 - Repeated measurements and long-term monitoring are possible. - There is no dye leaching into the measurement target. - Design for pH ranges (entire range, acidic, neutral, basic) is possible. - It can be made into films and fibers. 【Applications of the Technology】 - Development of pH sensors We are advancing the development of pH sensors through colorimetric measurement of the film-formulated pH indicator copolymer. - Fiberization By introducing it into chemical fibers, it is possible to realize fibers and non-woven fabrics with pH indicator functions. By film-forming and fiberizing the pH indicator copolymer, various application developments are expected.

• Other polymer materials

The "Variable Magnetic Flux Motor (MC Motor)" utilizes the properties of magnetic composite materials, including "low iron loss," "high strength," and "low saturation magnetic flux density." Compared to the reference IPM motor, the high-efficiency range (over 96%) has been expanded into the high-speed region. Copper loss is reduced by 40%, and iron loss and magnetic eddy current loss are reduced by 50%. Applications are expected in products equipped with inverter motors, such as washing machines, refrigerators, air conditioners, dishwashers, and main motors for electric vehicles. 【Features】 - Utilizes "low iron loss," "high strength," and "low saturation magnetic flux density" - High-efficiency range (over 96%) expanded into the high-speed region compared to the reference IPM motor - Copper loss reduced by 40% - Iron loss and magnetic eddy current loss reduced by 50% - High efficiency across a wide speed and torque range *For more details, please refer to the PDF materials or feel free to contact us.

• DC Motor

Formalin (a solution of formaldehyde) is used as a component in adhesives across various fields, but it is a substance that causes health issues, exemplified by sick house syndrome. To solve this problem, it is necessary to discover substances that have two or more aldehyde groups, are water-soluble and non-volatile, and do not rely on fossil resources. Therefore, we propose aldehyde compounds obtained by oxidizing sugars. These can be industrially produced through the oxidation of sugars using sodium periodate. [Issues] - While it is used as a component in adhesives across various fields, it is a substance that causes health issues, represented by sick house syndrome. - There are concerns about future depletion since the raw material is natural gas (methane). *For more details, please refer to the PDF document or feel free to contact us.*

• glue

Hydrogen is gaining attention as a clean energy source, and methods for producing hydrogen with low environmental impact are in demand. Artificial photosynthesis using photocatalysts to directly generate hydrogen from sunlight realizes a sustainable energy system. Modification of silane coupling agents with phosphonyl groups also promotes similar proton supply in photocatalytic hydrogen production. 【Research Content (Partial)】 ■CTGS - Recently attracting attention as a high-efficiency thin-film solar cell material - Constituent elements are inexpensive, safe, and zinc-free - Gradual control of the band gap according to the Sn/Ge ratio *For more details, please refer to the PDF document or feel free to contact us.

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We will introduce the technology for producing membranes for water treatment that allows for advanced control. A challenge has been the decrease in membrane performance due to the adhesion of organic substances, making it difficult to achieve the precise control of pore size necessary for improving permeability and separation performance. To address this, we produced water treatment membranes using polymer grafting via ATRP. Surface modification using functional polymers (MEDSAH) is effective in suppressing the adhesion of proteins and microorganisms, and by controlling the immobilization density and length of the polymers, we can control membrane performance. [Challenges] ■ Adhesion suppression: Membrane performance decreases due to the adhesion of organic substances. ■ Pore size control: Precise control of pore size, which is necessary for improving permeability and separation performance, is difficult. *For more details, please refer to the PDF document or feel free to contact us.

• Other polymer materials

We will introduce the results of the development of a new acid catalyst aimed at the efficient synthesis of "cyclic carbonate," used in electrolytes for lithium-ion batteries, and "oxazolidinone," which is widely present in pharmaceuticals. Conventional technologies have left challenges such as requiring high-temperature heating and having limited substrate generality. In this context, we successfully used magnesium iodide as a metal salt in reactions employing isocyanates to obtain oxazolidinone with good yields under mild conditions of 35°C. The production and sale of this catalyst, aimed at use in the manufacturing processes of organic materials and pharmaceuticals, is anticipated. 【Conventional Technology and Challenges】 ■ There are relatively few reports of reactions involving the mild conditions of atmospheric carbon dioxide through the simple operation of adding ligands to commercially available metal salts. ■ Requires high-temperature heating. ■ Limited substrate generality. *For more details, please refer to the PDF document or feel free to contact us.

• Other polymer materials

Bacterial cellulose (BC) is produced by microorganisms and is 100 to 1000 times thinner than plant-derived cellulose, with excellent biodegradability and water retention properties. This study explored methods that could lead to the mass production of materials expected to have various applications. Since the microorganisms originally do not have the ability to produce BC, it is difficult to expect sufficient production levels of BC, and the cost becomes a challenge when seeking mass production. In the method for mass production of BC derived from research results, cases were confirmed where a symbiotic relationship is established between cellulose-producing bacteria and photosynthetic microorganisms. This enables the production of BC using microorganisms that can be cultured in the field. 【Conventional Technology and Issues】 ■ Difficulties in outdoor cultivation and management ■ Since the microorganisms originally do not have the ability to produce BC, it is difficult to expect sufficient production levels of BC ■ High costs associated with seeking mass production *For more details, please refer to the PDF document or feel free to contact us.

• Other polymer materials

The present invention is a chemical synthesis technology for proanthocyanidins, specifically "epigallocatechin oligomers." Proanthocyanidins, "epigallocatechin oligomers," are a type of polyphenol that is expected to have metastasis-inhibiting effects on cancer cells, and there are expectations for the development of functional foods that have never been seen before, as well as their use as reagents.

• Organic Natural Materials

Fusicoccin, a diterpene glycoside isolated as a metabolic product of fungi that parasitize trees such as almonds, has been reported to irreversibly open plant stomata and induce continuous transpiration, leading to the death of the plant. In this invention, it has been revealed that under sufficient light and water supply, fusicoccin functions as a plant growth enhancer.

• others

Traditionally, methods for producing graphene have involved vapor-phase methods or exfoliation methods. Vapor-phase methods can produce highly crystalline graphene, but they have the challenge of high costs, while exfoliation methods are low-cost but result in graphene with low crystallinity. This technology involves a method for uniformly dispersing partially oxidized graphene with low oxygen content in a hydrophobic ionic liquid through the electrochemical exfoliation of graphite in a water-hydrophobic ionic liquid two-phase system. 【Features of the Technology】 - Two-phase system (water-hydrophobic ionic liquid) electrochemical exfoliation method - Surface oxygen concentration below 10%, eliminating the need for re-reduction treatment - Control of surface oxygen concentration is possible A wide range of materials can be applied to the graphite electrodes, and by exploring ways to reuse the ionic liquid, significant reductions in manufacturing costs are expected.

• Composite Materials

Introducing the "Electret Capacitor Sensor (ECS)." It is possible to manufacture thin and flexible electret capacitors using silica aggregate electrets. Even in contact with the target object, it can measure acoustic and ultrasonic waves, making it applicable for monitoring plant activities and bioacoustic sensing. 【Technical Features】 - Capable of wideband sensing (from below 1 Hz to above 200 kHz) - Pressure resistance, heat resistance, and moisture resistance - Suitable for air, biological systems, soft materials, and can also be applied underwater - Thin and flexible

• Other measurement, recording and measuring instruments

I would like to introduce "water-soluble porphyrin derivatives." Porphyrins are used in photodynamic diagnosis (PDD) and photodynamic therapy (PDT) for cancer diseases; however, porphyrins typically lack water solubility and biocompatibility, and they require time for metabolism. This technology allows for the synthesis of water-soluble porphyrin derivatives by combining porphyrins with sugar chains that exhibit excellent water solubility and biocompatibility. 【Features of the technology】 - Water solubility - Biocompatibility - Polymer derivatives (can be processed into films)

• Other polymer materials

Introducing the "Ultrasonic Pump." Conventional ultrasonic pumps have complex structures and are expensive. This technology features a very simple structure, making it possible to use in environments where it was previously difficult, as well as achieving compactness and low cost. ■ Features 〇 Simple Structure - Composed of three parts: ultrasonic vibration section, flow path parts (horn section), and opposing parts, resulting in a simple structure. - Miniaturization is also possible. 〇 No sliding or rotating parts like pistons or valves - No wear or damage. - Maintenance is easy. 〇 Usable over a wide temperature range - Does not use materials like rubber, allowing for a wide selection of materials. - Operates down to ultra-low temperatures like liquid nitrogen. - High-temperature range up to the operating range of the ultrasonic transducer (Curie temperature). - Depending on material selection, usage in strong magnetic fields is also possible. *For more details, please refer to the PDF document or feel free to contact us.

• others

Introducing a technology for the simple and highly accurate quantification of surface charge sites in nanomaterials. Conventional surface charge site quantification techniques have faced challenges such as being time-consuming and labor-intensive, and the high cost of automatic titration devices. In this technology, the sample size is extremely small compared to titration methods, and it can be executed using only highly versatile equipment. Additionally, it allows for rapid (within 2 hours) and simple operations, achieving measurement accuracy comparable to titration methods. **Features** - The sample size is extremely small compared to titration methods (0.5 to 2.5 mg per run). - Can be executed using only highly versatile equipment (centrifuge and visible light spectrophotometer). - Allows for rapid (within 2 hours) and simple operations, achieving measurement accuracy comparable to titration methods. - Enables individual quantification of strong acidic sites (sulfuric ester groups) and weak acidic sites (carboxyl groups). - Dye adsorption is completed in 2 hours. *For more details, please refer to the PDF document or feel free to contact us.*

• others

Introducing the creation of hydrogel fibers using microchannels. This technology allows for a gentle progression of the gelation reaction within a microchannel with a flow-focusing structure, making shape control easy. It enables the precise fabrication of single-strand hydrogel fibers (approximately 100μm in thickness). Additionally, scaling up through parallelization is also achievable. 【Features】 ■ Easy shape control ■ Gentle progression of the gelation reaction within a microchannel with a flow-focusing structure *For more details, please refer to the PDF document or feel free to contact us.

• others

We will introduce the technology for directly cultivating clay nanosheets with excellent adsorption properties using silica gel. Cation exchange materials are utilized by being packed into columns or dispersed in water, but in the latter case, it is important that the adsorbent can be easily recovered. In conventional technologies, recovery through filtration or centrifugation can be difficult when dealing with fine particles (at the nanoscale). In this technology, the material hardly delaminates even in solvents that typically cause swelling and delamination, making recovery from the solution easy. Since it thinly coats the silica surface, it is useful for separation in distribution systems. 【Features】 - Hardly delaminates even in solvents that cause swelling and delamination - Easy recovery from the solution - Thinly coats the silica surface, aiding in separation in distribution systems - Not dependent on the shape of the starting silica *For more details, please refer to the PDF document or feel free to contact us.

• others

We will introduce a translucent electrode made of photocatalytic powder and a "water-splitting tandem cell" using it. By using titania nanosheets as both an anchor and conductive layer for the powder, we have developed a novel method to create a translucent photoanode from photocatalytic powder materials. By using this translucent powder photoanode as the top cell and a powder photocathode for hydrogen generation as the bottom cell, we enable the construction of a powder material-based tandem cell capable of complete water splitting under sunlight irradiation. 【Features】 ■ Tandem structure ■ Reaction driven in a self-sustained state without wiring ■ No need for product separation ■ Steam splitting (potential use of seawater) ■ Useful energy carrier *For more details, please refer to the PDF document or feel free to contact us.

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We will introduce researchers and technological seeds suitable for your company's product/technology development/research. Since our establishment, we have supported the commercialization of various companies. We have extensive experience and achievements in commercializing technologies developed at universities and launching new businesses utilizing subsidies. Please feel free to contact us. ■ Technology Transfer Services - Introduction of researchers and technical information (such as patents) - Coordination of technical guidance by researchers - Mediation of joint research and commissioned research - Support for obtaining patents and rights ■ Commercialization Support Services - Mediation and contracting of grant projects - Implementation of lectures and basic courses - Support for interaction between companies and researchers

• Other services