信和化工 List of Products and Services

The "ULTRON HF-ODS" is an ODS monolithic silica capillary column (USP L1) with a hierarchical porous structure, chemically bonded with C18 groups. The well-balanced hydrophilic/hydrophobic C18 modification suppresses dewetting, allowing for high reproducibility in water-rich mobile phase systems used in bioanalysis. Two types of columns are available: full end-capping and non-end-capping. The column inner diameter is 0.1 mm, making it suitable for nano/micro-LC/MS that requires high sensitivity detection. 【Features】 ■ Enables high reproducibility and high peak capacity in proteome analysis (shotgun method) ■ Achieves suppression of carryover through inert treatment of the silica surface ■ The column is protected by a PEEK column jacket, making it easy to handle ■ Analyzes thousands of proteins with long columns *There is also an unmodified monolithic bare silica capillary tube (ULTRON HF-MBS) available.

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This is a monolithic silica capillary column with a hierarchical porous structure, chemically bonded with low-adsorption functional groups (C4). It enables low-pressure and low-temperature analysis of intact proteins, making it suitable for LC/MS analysis under mild conditions. With high resolution, it allows for precise analysis of intact proteins and simultaneous analysis of various proteins. Please use it for research and development in the era of modality diversification, such as simultaneous LC/MS analysis of monoclonal antibodies, ADCs, and cell-expressed proteins. 【Features】 - Capable of separating intact proteins without enzymatic digestion. - Inactivation treatment on the silica surface suppresses carryover. - The column inner diameter is 0.1 mm, suitable for use with nano-flow LC. - The column is protected by a PEEK column jacket, making it easy to handle. *Unmodified monolithic silica capillary tubes (ULTRON HF-MBS) are also available. *For more details, please download the PDF or feel free to contact us. (Please also feel free to reach out if you would like a column demo.)

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"ULTRON HF-Phenyl" is a monolithic capillary column (USP L11) that chemically bonds low-adsorption phenyl groups to monolithic silica with a hierarchical porous structure. It can also be used for intact protein analysis via LC/MS. Mild low-temperature and low-pressure analysis can suppress protein denaturation. Due to the π-electron interactions of the phenyl groups, different separation patterns can be obtained compared to ODS columns and C4 columns. Please utilize it for research and development in the era of modality diversification, such as LC/MS analysis of monoclonal antibodies, ADCs, and cell-expressed proteins. 【Features】 ■ Realizes suppression of carryover through inert treatment of the silica surface ■ Expected to facilitate the exploration of unknown components and simultaneous analysis of various proteins ■ Column inner diameter is 0.1 mm, suitable for nano-flow LC ■ Suitable for LC/MS requiring high sensitivity detection ■ The column is protected by a PEEK column jacket, making it easy to handle *Unmodified capillaries (ULTRON HF-MBS) are also available. *For more details, please download the PDF or feel free to contact us. (If you would like a column demo, please feel free to reach out.)

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Shinwasorb is an original porous silica powder from Shinwa Chemical. It was designed and developed using monolithic silica technology, inspired by the widely used white diatomaceous earth (Chromosorb) in gas chromatography. It has an appearance, physical strength, and heat resistance similar to white diatomaceous earth. As a result, it addresses the issues associated with natural diatomaceous earth that requires soil mining (reproducibility, impurities, environmental impact). As a new material that aligns with the SDGs, it can be widely used as an alternative to diatomaceous earth for gas chromatography. ■ Features of Shinwasorb (as a carrier for gas chromatography) - There is no variation between lots since it is a chemically synthesized product. - There are almost no micropores (micro and mesopores), resulting in no adsorption of components. - It is high-purity silica and does not contain heavy metals or other impurities. - It has excellent physical strength and generates very little fine powder. - It has a specific surface area equal to or greater than that of diatomaceous earth carriers. - It can be coated with a variety of liquid phases (silicones) for gas chromatography.

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To realize a carbon dioxide-free hydrogen energy society, the production and utilization of high-purity hydrogen are required. Our original adsorbent "Shincarbon-ST" has a special structure that can adsorb and separate inorganic gases such as hydrogen. For example, when used as a column for gas chromatography, it enables the simultaneous analysis of H2, O2, N2, CO, CH4, and CO2. Please utilize "Shincarbon-ST" for gas research and development aimed at achieving a hydrogen energy society, including hydrogen quality inspection, hydrogen generation monitoring, and hydrogen gas purification.

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Lithium-ion secondary batteries are known to degrade the electrolyte and release gases due to repeated charging and discharging. The MICROPACKED-ST column is the optimal column for gas chromatography analysis of gas components generated from lithium-ion batteries (such as H2, O2, N2, CO, CH4, CO2, C2H4, C2H6, etc.). The MICROPACKED-ST column is filled with ShinCarbon-ST, an original product of Shinwa Chemical Industries. Various detectors such as TCD and MS can be used, making it widely useful for research and development as well as quality testing of lithium-ion secondary batteries.

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• Lithium-ion battery
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ULTRON ES-OVM-3 accelerates chiral separation and analysis using reverse-phase HPLC, a feature of ULTRON ES-OVM. It utilizes ovalbumin, an egg white protein, as a chiral recognition ligand, allowing for the chiral identification of many pharmaceuticals that dock with proteins. Chiral analysis of many pharmaceuticals, starting with Clopidogrel bisulfate, which utilizes ULTRON ES-OVM (USP L57), can be completed in 5 to 10 minutes. The following pharmaceuticals undergo ultra-fast reverse-phase chiral analysis in just under 5 minutes. For more details, please contact our company or your representative. - Clopidogrel bisulfate - Amlodipine - Atomoxetine hydrochloride - Carvedilol - Duloxetine hydrochloride - Tolperisone hydrochloride - Tolterodine

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ULTRON ES-OVM is designated as an evaluation column for Clopidogrel bisulfate and Escitalopram oxalate in the United States Pharmacopeia (USP). It also corresponds to the ovomucoid chemically bonded amino silica gel described in the Japanese Pharmacopoeia (JP). ■ULTRON ES-OVM (USP L57) It uses ovomucoid, which is resistant to denaturation, as the ligand. 〈Product Lineup〉 ULTRON ES-OVM ULTRON ES-OVM-3 can be used for UHPLC and LC/MS ULTRON ES-OVM-C for shipping inspection with Clopidogrel bisulfate (USP compliant) ULTRON ES-OVM-E for shipping inspection with Escitalopram oxalate (USP compliant) ■ULTRON ES-PEPSIN It uses pepsin, a polypeptide-degrading enzyme, as the ligand. It is effective for the chiral separation of β-blockers.

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The "Ultron ES-OVM" is an optical separation HPLC column that has many excellent features, such as being easy to use in reverse phase mode, having good peak shape, and being suitable for the study of trace metabolites. It uses amino-modified silica gel with proteins that are resistant to denaturation as the stationary phase, allowing for the analysis of plasma samples without any pre-treatment. This document includes the basic properties of the ligand, examples of separation degree adjustment, and case studies of compound analysis using the Ultron ES-OVM. We encourage you to read it. [Contents] ■ Basic properties of the ligand ■ Mechanism of separation ■ Selection of mobile phase ■ Relationship between pH and capacity factor ■ Relationship between salt concentration and capacity factor *For more details, please refer to the PDF document or feel free to contact us.

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The "ULTRON AF-HILIC" series consists of columns for hydrophilic interaction chromatography (HILIC), featuring high-polarity functional groups that are surface-modified to retain polar compounds that are difficult to retain in reverse phase mode. **Features** [ULTRON AF-HILIC-CD] - β-cyclodextrin is chemically bonded to a silica substrate via a spacer. - High selectivity for molecular structures, enabling high-resolution analysis of structural analogs and structural isomers of acidic to neutral compounds. - Optimization of the amount of β-cyclodextrin introduced achieves diverse separation selectivity along with excellent reproducibility and durability. - Adaptable for qualitative and quantitative analysis of sugars by suppressing the formation of Schiff bases and anomer separation. [ULTRON AF-HILIC-DA] - The filler is based on a silica substrate, introducing new amino groups via a spacer with diamines (primary, secondary). - Significantly improves retention while maintaining the characteristics of amino columns. - Strong retention for polar compounds. - Suitable for the separation of neutral to basic compounds.

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