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ε-Polylysine (hereafter referred to as Polylysine) is a homopolymer consisting of 25 to 35 linked ε-amino groups of L-lysine, an essential amino acid for humans, and α-carboxyl groups through amide bonds. With over 30 years of manufacturing experience, it is an amino acid-derived preservative widely used as a food preservative, making it applicable in sanitary materials and more. For example, it is expected to reduce synthetic polymers in everyday items closely related to daily life, such as wet wipes, toothpaste, shampoo, and scalp care products. Even in the presence of chelating agents used as antioxidants in cosmetics, various detergents, chemicals, and pharmaceuticals, it exhibits excellent antibacterial properties. Additionally, it is utilized in preventing bacterial contamination during the manufacturing process of food raw materials, removing anionic substances by leveraging the characteristics of cationic polymers, and in applications for electronic materials and semiconductor manufacturing. 【Features】 ■ A safe material produced through fermentation by natural microorganisms (not genetically modified organisms) ■ Provides a positive image as a natural fermentation product ■ Listed in the existing additive inventory as a food preservative ■ Can be used as an additive in cosmetics, sanitary materials, and daily necessities ■ A safe domestic product ■ A natural cationic polymer

ε-Polylysine (hereafter referred to as Polylysine) is a substance officially known as ε-Poly-L-lysine. It has over 30 years of manufacturing history since 1989 and is widely used as a preservative in food. Polylysine is a natural food preservative produced through fermentation. Due to its high safety, we have received numerous requests to use it for various antibacterial applications. In response to customer feedback, we have started selling it as a reagent. The reagent can be purchased from Fujifilm Wako Pure Chemical Corporation. For example, it is expected to reduce synthetic polymers in everyday products closely related to daily life, such as wet wipes, toothpaste, shampoo, and scalp care. 【Features】 ■ Safe natural microbial fermentation product (not genetically modified organism) ■ Provides a positive image as a natural fermentation product ■ Listed in the existing additive inventory as a food preservative ■ Can be used as an additive in cosmetics, hygiene materials, and daily necessities ■ A safe domestic product *For more details, please download the PDF or feel free to contact us.

ε-Polylysine (hereinafter referred to as Polylysine) is a substance formally known as ε-Poly-L-lysine. It is a homopolymer consisting of 25 to 35 units linked by amide bonds, formed from the amino group at the ε position and the carboxyl group at the α position of the essential amino acid L-lysine. Since 1989, it has over 30 years of manufacturing experience and is widely used as a food preservative. Here, we introduce the safety of Polylysine. Polylysine has been confirmed to have high safety through acute toxicity, subacute toxicity, chronic toxicity, mutagenicity, and pharmacokinetic tests in accordance with the guidelines of the Ministry of Health, Labour and Welfare. 【Content Overview】 ■ Acute toxicity test (rats) ■ Carcinogenicity test (rats) ■ Mutagenicity test (microorganisms) ■ 3-month repeated dose toxicity test (rats) ■ Teratogenicity and reproductive test (rats) ■ Chronic toxicity/carcinogenicity combined test (rats) *For more details, please download the PDF or feel free to contact us.

ε-Polylysine (hereinafter referred to as Polylysine) is a substance officially known as ε-Poly-L-lysine. It is a homopolymer consisting of 25 to 35 units linked by amide bonds, formed from the ε-amino group of the essential amino acid L-lysine and the α-carboxyl group. Since 1989, it has over 30 years of manufacturing history and is widely used as a preservative in food. We will introduce the effects of heat treatment on the antibacterial effect of Polylysine. The antibacterial effect of Polylysine does not change even after heating at 120°C for 2 hours. Since food is often subjected to heating during processing, Polylysine, which has excellent thermal stability, can be suitably used in heat-requiring foods. *For more details, please download the PDF or feel free to contact us.

Polylysine is widely used as a food additive and, thanks to its GRAS certification (Note) from the U.S. FDA, is recognized as a global standard food preservative. As of August 2, 2022, the only polylysine with FDA GRAS certification is the polylysine produced by JNC Corporation. Polylysine is a naturally occurring amino acid-derived substance produced by microbial fermentation, similar to miso, soy sauce, yogurt, and other products. Polylysine ionically adsorbs to microorganisms, inhibiting their growth. Due to its broad antibacterial properties and excellent flavor-preserving properties, it is primarily used to extend the shelf life of foods, and is used in a wide range of food products, including ekiben (boxed lunches), soraben (boxed lunches sold at supermarkets), and prepared meals. Note: GRAS (Generally Recognized as Safe) is a safety standard certification given to food additives by the U.S. Food and Drug Administration (FDA). To be generally recognized as safe through scientific procedures, quantitative and qualitative scientific evidence equivalent to that required for approval of a substance as a food additive is required. *For more information, please download the PDF or feel free to contact us.

ε-Polylysine (hereafter referred to as Polylysine) is a substance formally known as ε-Poly-L-lysine. It is a homopolymer consisting of 25 to 35 units linked by amide bonds, formed from the ε-amino group and the α-carboxyl group of the essential amino acid L-lysine. Since 1989, it has over 30 years of manufacturing history and is widely used as a food preservative amino acid. We will introduce the minimum inhibitory concentration (MIC) of Polylysine against various microorganisms. Polylysine exhibits antibacterial effects at concentrations ranging from a few ppm to several hundred ppm, regardless of the type of bacteria, yeast, or mold. *For more details, please download the PDF or feel free to contact us.

ε-Polylysine (hereinafter referred to as Polylysine) is a substance formally known as ε-Poly-L-lysine. It is a homopolymer consisting of 25 to 35 units linked by amide bonds, formed from the ε-amino group of the essential amino acid L-lysine and the α-carboxyl group. Since 1989, it has over 30 years of manufacturing experience and is widely used as a preservative in food. We present the minimum inhibitory concentration (MIC) of Polylysine in combination with sorbic acid, acetic acid, and glycine at pH 5 to 9. Polylysine exhibits stable antibacterial effects at low concentrations across a wide pH range from weakly acidic to weakly alkaline. Many foods we consume have a pH close to weakly acidic to neutral. Polylysine, which shows stable antibacterial effects in small amounts across a wide pH range, can be suitably utilized in various foods. *For more details, please download the PDF or feel free to contact us.

ε-Polylysine (hereinafter referred to as Polylysine) is a substance formally known as ε-Poly-L-lysine. It is a homopolymer consisting of 25 to 35 units linked by amide bonds, formed from the ε-amino group and the α-carboxyl group of the essential amino acid L-lysine. Since 1989, it has over 30 years of manufacturing history and is widely used as a food preservative amino acid. It demonstrates inactivation effects against various microorganisms. Polylysine not only suppresses the growth of microorganisms but also has the effect of inactivating them. It similarly shows inactivation effects against enterohemorrhagic Escherichia coli O157:H7 and O111:H8. From the perspective of suppressing food spoilage, it is important to keep the initial bacterial count low, and Polylysine, which inactivates microorganisms and reduces the initial bacterial count, has excellent properties as a preservative. *For more details, please download the PDF or feel free to contact us.

ε-Polylysine (hereinafter referred to as Polylysine) is a substance formally known as ε-Poly-L-lysine. It is a homopolymer consisting of 25 to 35 units linked by amide bonds, formed from the ε-amino group of the essential amino acid L-lysine and the α-carboxyl group. Since 1989, it has over 30 years of manufacturing history and is widely used as a food preservative amino acid. Chelating agents are commonly used in food, cosmetics, various cleaning agents, chemicals, and pharmaceuticals as metal ion sequestrants and antioxidants. It is well known that chelating agents such as EDTA and sodium citrate exhibit antibacterial properties and have been used for antibacterial purposes for a long time. We present the minimum inhibitory concentration (MIC) against Escherichia coli and Staphylococcus aureus when using Polylysine in combination with EDTA. The growth inhibition effect against each microorganism is synergistically enhanced by the combination of Polylysine and EDTA. *For more details, please download the PDF or feel free to contact us.*

ε-Polylysine (hereinafter referred to as Polylysine) is a substance formally known as ε-Poly-L-lysine. It is a homopolymer consisting of 25 to 35 units linked by amide bonds, formed from the ε-amino group of the essential amino acid L-lysine and the α-carboxyl group. Since 1989, it has over 30 years of manufacturing experience and is widely used as a food preservative amino acid. It was found that the combination of Polylysine and natto extract suppresses the infection of feline calicivirus (NCV) in cells. Since Polylysine and natto extract do not show infection suppression effects when used alone, the combination of Polylysine with other bioactive substances can provide new added value to Polylysine. *For more details, please download the PDF or feel free to contact us.

ε-Polylysine (hereinafter referred to as Polylysine) is a homopolymer consisting of 25 to 35 units formed by the amine group at the ε-position and the carboxyl group at the α-position of the amino acid L-lysine, linked by amide bonds. It has over 30 years of manufacturing experience and is widely used as a food preservative derived from amino acids. By adding Polylysine, the growth of microorganisms that cause food poisoning can be prevented. Every year, food poisoning caused by microorganisms is a significant issue and is frequently reported in the news. Even foods that appear to be fresh can experience rapid microbial growth if the conditions are right, so caution is necessary. Even if the appearance is good, contamination by bacteria can progress, posing a risk of food poisoning. In addition to hygiene management during the manufacturing process and proper storage at appropriate temperatures, the effective use of the preservative Polylysine can help ensure food safety more effectively. 【Features】 ■ A safe material produced through fermentation by natural microorganisms (not genetically modified organisms) ■ Provides a positive image as a natural fermentation product ■ Listed in the existing additive registry as a food preservative ■ A safe domestic product

ε-Polylysine (hereinafter referred to as Polylysine) is a substance formally known as ε-Poly-L-lysine. It is a homopolymer consisting of 25 to 35 units linked by amide bonds, formed from the ε-amino group and the α-carboxyl group of the essential amino acid L-lysine. Since 1989, it has over 30 years of manufacturing history and is widely used as a food preservative amino acid. Polylysine has excellent antibacterial properties on its own, but when added to food, its effectiveness may not be fully realized due to the influence of food components. Therefore, when used in food, it can be combined with other substances to mitigate the effects of food components or enhance its antibacterial effects. In particular, combining Polylysine with substances that suppress microorganisms through different mechanisms, such as ethanol, organic acids, glycine, and glycerol fatty acid esters, can yield excellent synergistic effects. [Content] ■ Combination with ethanol ■ Combination with organic acids ■ Combination with glycine ■ Combination with glycerol fatty acid esters *For more details, please download the PDF or feel free to contact us.

ε-polylysine (hereinafter referred to as Polylysine) is a homopolymer consisting of 25 to 35 units of the amino acid L-lysine, where the amino group at the ε position and the carboxyl group at the α position are linked by amide bonds. It has over 30 years of manufacturing history and is widely used as a food preservative derived from amino acids. Bread making involves many processes, but if the dough can be frozen after shaping, it allows for the omission of steps prior to secondary fermentation, significantly reducing the time required for thawing, fermentation, and baking. However, freezing the dough can lead to the destruction of yeast cells and damage to the dough structure due to ice crystal formation, resulting in a decrease in volume. This volume reduction is one of the freezing injuries of bread dough. Polylysine is a safe fermented food that has been used as a preservative for many years and has the function of suppressing freezing injuries in bread. Bread with added Polylysine bakes up fluffier compared to bread without it. 【Features】 ■ A safe material produced through fermentation by natural microorganisms (not genetically modified organisms) ■ Provides a positive image as a natural fermentation product ■ Listed in the existing additive registry as a food preservative ■ A safe domestic product

ε-Polylysine (hereinafter referred to as Polylysine) is a substance formally known as ε-Poly-L-lysine. It is a homopolymer consisting of 25 to 35 units linked by amide bonds, formed from the ε-amino group and the α-carboxyl group of the essential amino acid L-lysine. Since 1989, it has over 30 years of manufacturing history and is widely used as a food preservative. Efforts are actively being made to impart the excellent antibacterial effects of Polylysine to various materials such as textiles, paints, and resin products. By immersing fibers in a Polylysine solution, it is possible to obtain antibacterial fibers with high safety for the human body. We will introduce the antibacterial effects against Staphylococcus aureus and Klebsiella pneumoniae after washing various fibers treated by immersion in Polylysine. Various fibers treated by immersion in a Polylysine solution showed antibacterial effects even after washing. *For more details, please download the PDF or feel free to contact us.

ε-Polylysine (hereinafter referred to as Polylysine) is a substance formally known as ε-poly-L-lysine. It is a homopolymer consisting of 25 to 35 units linked by amide bonds, formed from the ε-amino group of the essential amino acid L-lysine and the α-carboxyl group. Since 1989, it has over 30 years of manufacturing history and is widely used as a food preservative amino acid. By uniformly dispersing Polylysine in aqueous emulsion resin, an antibacterial paint can be obtained that has low environmental impact from volatile organic compounds (VOCs) and high safety for human health. This introduces the antibacterial effects against Escherichia coli, Staphylococcus aureus, and Bacillus subtilis of polypropylene sheets coated with polyvinyl butyral resin dispersed with Polylysine. Sheets coated with polyvinyl butyral resin containing Polylysine exhibit antibacterial effects that depend on the amount of Polylysine in the coating film against each microorganism. *For more details, please download the PDF or feel free to contact us.

ε-Polylysine (hereinafter referred to as Polylysine) is a substance formally known as ε-Poly-L-lysine. It is a homopolymer consisting of 25 to 35 units linked by amide bonds, formed from the ε-amino group and the α-carboxyl group of the essential amino acid L-lysine. Since 1989, it has over 30 years of manufacturing experience and is widely used as a food preservative amino acid. By blending Polylysine into synthetic resins, antibacterial resins can be obtained. Additionally, it has been reported that using dispersants allows for antibacterial effects to be achieved with a smaller amount of Polylysine added. We introduce the antibacterial effect against E. coli of polypropylene sheets blended with Polylysine. Polypropylene sheets with added Polylysine showed antibacterial effects against E. coli. By using zinc stearate as a dispersant, antibacterial effects can be achieved with a smaller amount of Polylysine added. *For more details, please download the PDF or feel free to contact us.

E-Polylysine(hereinafter referred to as Polylysine) is a substance officially known as ε-Poly-L-lysine. It is a homopolymer consisting of 25 to 35 units linked by amide bonds, formed from the amino group at the ε position and the carboxyl group at the α position of the essential amino acid L-lysine. Since 1989, it has over 30 years of manufacturing history and is widely used as a food preservative amino acid. As a product of natural microbial fermentation, it can reduce the use of synthetic food preservatives derived from chemical substances. Polylysine is a cationic polymer with a positive charge. It electrically binds to negatively charged microbial cell membranes, inhibiting microbial growth. Polylysine is listed in the existing additive inventory of the Ministry of Health, Labour and Welfare (No. 397). Example of labeling: Preservative (Polylysine). **Features** - Safe natural microbial fermentation product (not derived from genetically modified organisms) - Provides a good image as a natural fermentation product - Listed in the existing additive inventory as a food preservative - Usable in various foods such as bento, side dishes, various processed foods, bakery products, and confectionery - A safe domestic food product *For more details, please download the PDF or feel free to contact us.*

ε-Polylysine (hereinafter referred to as Polylysine) is a homopolymer consisting of 25 to 35 units formed by the amine group at the ε position and the carboxyl group at the α position of the amino acid L-lysine, linked by amide bonds. It has over 30 years of manufacturing history and is widely used as an amino acid-derived food preservative. The shelf life of typical pet food is 2 to 3 years, but wet-type pet foods, such as treats, often have a shorter shelf life of only about 1 year. Methods for extending shelf life include canning, pouch processing, and converting to dry food, but these are not suitable for flavorful pet foods like wet types. Additionally, some pet owners do not refrigerate after opening. This can lead to mold growth or spoilage during storage, potentially harming the pet's health. Polylysine is a food preservative used in bento, bread, and side dishes, and it is gaining attention as a food preservative that can help prevent spoilage in pet food. 【Features】 ■ A safe material produced through fermentation by natural microorganisms (not genetically modified organisms) ■ Provides a positive image as a natural fermentation product ■ Listed in the existing additive registry as a food preservative ■ A safe domestically produced product

1. ε-Polylysine A safe polyamino acid food preservative produced by natural microorganisms. It has over 30 years of manufacturing experience. In recent years, due to its high safety, it has been used in everyday products such as wet wipes, toothpaste, shampoos, hygiene materials, cosmetics, various cleaning agents, chemicals, and pharmaceuticals. It is also applied in preventing bacterial contamination during the manufacturing process of food ingredients, utilizing its high antibacterial properties, as well as in the removal of anionic substances using the characteristics of cationic substances, and as an additive in semiconductor CMP slurries. 2. MC-Media Pad A sheet-like microbial testing medium that serves as an alternative to agar media. By using the MC-Media Pad, there is no need for medium preparation like with agar media, allowing for space-saving and rapid microbial testing, significantly reducing the time required for testing. Additionally, compared to agar media, the amount of waste is reduced to about one-twentieth, contributing to the SDGs. It is a product certified by international certifications such as AOAC-PTM, AOAC-OMA, and MicroVal, and is listed in the food hygiene inspection guidelines, making it safe for use in compliance with HACCP.