渡辺化学工業 List of Products and Services

These trapping reagents can be used for the detection and analysis of reactive metabolites that may arise during the metabolic processes of drug candidate compounds. ◆R00846 CysGlu-Dan Traditionally, Dansyl-GSH (dGSH) has been used in trapping tests for electrophilic reactive metabolites generated by CYP oxidation; however, Dansyl-GSH was unable to detect "hard" electrophilic reactive metabolites such as aldehydes. CysGlu-Dan, like Dansyl-GSH, can react with "soft" electrophilic reactive metabolites such as quinones and epoxides, as well as with "hard" electrophilic reactive metabolites, allowing for the sensitive detection of a broader range of reactive metabolites. ◆R00845 Dap-Dan This reagent can trap and detect reactive 1-O-acyl glucuronides generated during the glucuronidation process, as well as aldehydes produced through rearrangement. ◆R00847 Cys-Dan This reagent can trap and detect reactive acyl-CoA generated during the metabolic processes of fatty acids. These trapping reagents were developed by a group led by Professor Tomoyuki Oe at the Faculty of Pharmacy, Keio University.

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◆It can be used for the deprotection of Boc groups and the preparation of hydrochloride salts. ◆You can choose from four types of organic solvents depending on the solubility of the compound and the manufacturing process. ◆Delivery in bulk volume (9L) and custom orders (specifications, on-site/written audit support, etc.) are also possible. ◆It will be delivered sealed in a brown glass bottle, which is further placed in a polypropylene outer container.

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We would like to introduce our "Fmoc-N-Alkyl Glycines." Our lineup includes "Fmoc-EtGly-OH," "Fmoc-nPrGly-OH," and "Fmoc-nBuGly-OH," among others. For amino acid derivatives, please leave it to Watanabe Chemical Industry. 【Partial Lineup】 ■Fmoc-EtGly-OH ■Fmoc-nPrGly-OH ■Fmoc-nBuGly-OH ■Fmoc-nHexGly-OH *For more details, please refer to the PDF document or feel free to contact us.

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In this document, we are introducing new products from Watanabe Chemical Industries. We present products such as "Fmoc-Pic(4)(4-NHBoc)-OH/Boc-Pip(Fmoc)-OH" and "Fmoc-Phe(3-Guad-Pbf,Sub)-OH." In addition, we have a wide range of other products listed. Please take a moment to read through. 【Contents (partial)】 ■Fmoc-Pic(4)(4-NHBoc)-OH/Boc-Pip(Fmoc)-OH ■Boc-Pic(4)(4-NHFmoc)-OH/Fmoc-Pip(Boc)-OH ■tBuOCOCH2-Pic(4)(4-NHFmoc)-OH/Fmoc-Pip(CH2COOtBu)-OH ■Fmoc-Ala[cHex(4-Aza,4-CH2COOtBu)]-OH *For more details, please refer to the PDF document or feel free to contact us.

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We would like to introduce 'Aloc-Amino Acids' handled by Watanabe Chemical Industries. Our lineup includes "Aloc-Ala-OH·DCHA," "Aloc-Arg(Pbf)-OH," and "Aloc-Asn(Trt)-OH·DCHA," among others. We offer 20 types of L-amino acids. Please feel free to contact us when you need them. 【Partial Lineup】 ■Aloc-Ala-OH·DCHA ■Aloc-Arg(Pbf)-OH ■Aloc-Asn(Trt)-OH·DCHA ■Aloc-Asp(OtBu)-OH·DCHA *For more details, please refer to the PDF document or feel free to contact us.

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In this document, we introduce the "non-natural amino acids" handled by Watanabe Chemical Industries. We feature "Asn/Gln derivatives," as well as "N-phenyl Dap derivatives" and "diazo amino acids." Additionally, we have "N-benzylglycine derivatives," such as "Fmoc-(Dmb)Gly-OH" and "Fmoc-(Hmb)Gly-OH," which are useful for difficult peptide synthesis. We invite you to read it. [Contents] ■ Asn/Gln derivatives ■ N-phenyl Dap derivatives ■ Diazo amino acids ■ Non-natural aromatic amino acids ■ N-benzylglycine derivatives useful for difficult peptide synthesis ■ Lys and Orn analogs *For more details, please refer to the PDF document or feel free to contact us.

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We would like to introduce our "N-Alkyl-PAL-PEG Resin." We offer "N-Methyl-PAL-PEG Resin" and "N-Ethyl-PAL-PEG Resin" in our lineup. Peptides with alkyl amides at the C-terminus can be directly synthesized using the Fmoc solid-phase method. Please feel free to contact us if you have any inquiries. 【Product Lineup】 ■N-Methyl-PAL-PEG Resin ■N-Ethyl-PAL-PEG Resin *For more details, please refer to the PDF document or feel free to contact us.

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This document introduces "photo-reactive diazirine amino acids." Diazirine absorbs relatively long-wavelength ultraviolet light around 350 nm, generating carbenes that insert into nearby C-H and N-H bonds, forming stable covalent bonds. Since this covalent bond formation occurs only at adjacent sites, there is no non-specific covalent bond formation. For more details, please refer to the related catalog, and we encourage you to read it. [Contents] ■ Photoaffinity labeling method ■ Photo-reactive base diazirine ■ Related products * For more information, please refer to the PDF document or feel free to contact us.

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"4N-HCl/MTHP" is an organic solvent MTHP that has been infused with hydrogen chloride gas, which is useful in process chemistry. It has solubility comparable to THF, allowing it to be used for a wider range of compounds, and it also has good solubility for inorganic salts. It is less likely to generate peroxides under air, making reactions and storage safer. 【Features (partial)】 ■ It separates from water, allowing for direct extraction after the reaction, simplifying the process. ■ It has solubility comparable to THF. ■ It can be used for a wider range of compounds. ■ It also has good solubility for inorganic salts. *For more details, please refer to the PDF materials or feel free to contact us.

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We would like to introduce our "Fmoc-PEG Amino Acids." Our lineup includes "Fmoc-AEA-OH," as well as "Fmoc-NH-PEG1-CH2CH2COOH" and "Fmoc-NH-PEG2-CH2CH2COOH." These can also be used for peptide solid-phase synthesis. Please feel free to contact us if you have any inquiries. 【Partial Lineup】 ■Fmoc-AEA-OH ■Fmoc-AEEA-OH/Fmoc-8-Adox-OH ■Fmoc-AEEEA-OH/Fmoc-NH-PEG3-CH2COOH ■Fmoc-NH-PEG4-CH2COOH *For more details, please refer to the PDF document or feel free to contact us.

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We would like to introduce our "peptide synthesis-related reagents." Starting with "coupling agents" such as carbodiimides and uronium, we also offer "deprotection reagents" like acidic/basic organic solvents. In addition, we have a variety of other reagents available. For more details, please download and view the related catalog. 【Product Lineup (Partial)】 ■ Coupling Agents - Carbodiimides, uronium, phosphonium phosphates, and others ■ Coupling Additives - Coupling accelerators, racemization suppressants, active ester formation reagents ■ Deprotection Reagents - Acidic/basic organic solvents, additives *For more details, please refer to the PDF materials or feel free to contact us.

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"ADC LINKER" is a dipeptide linker used as a component of antibody-drug conjugates. When it binds to and is taken up by cells expressing the antigen recognized by the antibody, hydrolysis occurs between Cit-pAB by cathepsin B inside the cell. The drug that is bound is then released. As a result, it allows for selective action of the drug on the target cells. Please feel free to contact us if you have any inquiries. 【Features】 ■ Useful for research on antibody-drug conjugates ■ When it binds to and is taken up by cells expressing the antigen recognized by the antibody, hydrolysis occurs between Cit-pAB by cathepsin B inside the cell ■ The drug that is bound is released *For more details, please refer to the PDF materials or feel free to contact us.

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The "XV-Resin series" has swelling properties that are equal to or greater than those of PEGA and Chemmatrix resins. It swells in various solvents (such as water, methanol, DMF, DCM, etc.). Difficult sequences of peptides, peptide aggregates, mini proteins, and PNA can be synthesized with high purity and high yield. 【Features】 ■ Swelling properties equal to or greater than those of PEGA and Chemmatrix resins ■ Swells in water, methanol, DMF, DCM, etc. ■ Difficult sequences of peptides, peptide aggregates, mini proteins, and PNA can be synthesized with high purity and high yield ■ Easy to handle *For more details, please refer to the PDF document or feel free to contact us.

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We would like to introduce our polypeptide synthesis monomer, "Amino Acid NPC." It remains stable for over three months when stored dry at 4°C to 25°C, and can be polymerized while maintaining its living characteristics and optical activity. Additionally, NCA can be synthesized without using phosgene. Please feel free to contact us if you have any inquiries. 【Features】 ■ More stable than NCA ■ Direct polypeptide synthesis from NPC is possible ■ Halogen-free *For more details, please refer to the PDF document or feel free to contact us.

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We would like to introduce our product, 'Triazepane/Oxadiazepane derivatives.' This product holds infinite potential as an alternative element to piperazine and morpholine. Please feel free to contact us when you need assistance. 【Product Lineup】 ■Boc(1)-Triazepane ■Di-Boc(1,2)-Triazepane・HCl ■Boc(2)-Oxadiazepane・HCl *For more details, please refer to the PDF document or feel free to contact us.

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The side chains contain acridone and benzoacridone, which emit yellow-green and light blue fluorescence, respectively. (Acd: λex=403nm, λem=442nm / Bacd: λex=455nm, λem=511nm) We offer three types: free form, Boc-protected form, and Fmoc-protected form, which can be used in various methods including peptide solid-phase synthesis. Since the fluorescence wavelength of Acd overlaps with the excitation wavelength of Bacd, they can be utilized as a FRET (Fluorescence Resonance Energy Transfer) pair for probe design.

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We actively conduct contract synthesis of short-chain peptides (2 to 5 amino acids). We have numerous synthesis achievements of over 10g. We offer catalog sales for relatively simple structures such as dipeptides and tripeptides. Additionally, we can accommodate large-scale synthesis of short-chain peptides, which is difficult to handle with solid-phase synthesis, through liquid-phase synthesis. 【Lineup (excerpt)】 ■ Fluorescently labeled peptides ■ Enzyme substrate peptides ■ Functional short-chain peptides ■ Imidazole dipeptides *For more details, please refer to the PDF document or feel free to contact us.

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Our company has over 30 years of extensive experience and achievements in selling peptide synthesis reagents. We offer same-day delivery, allowing us to deliver to customers the next day if the items are in stock. (Excluding certain areas such as Hokkaido, rural areas, mountainous regions, Okinawa, and remote islands) We set our internal purity standards for compounds at a high level and strive to deliver products with high purity that exceed the common standards in the reagent industry. Additionally, we cover almost all compounds that have amino and carboxyl groups. 【Achievements】 ■ Synthesis of amino acids with straight-chain alkyl groups as side chains ■ Synthesis of N-methyl amino acids with straight-chain alkyl groups as side chains ■ Synthesis of phenylalanine derivatives with various substituents on the benzene ring ■ Peptides containing stable isotopes ■ Manufacturing of resins for solid-phase synthesis capable of synthesizing N-methyl peptide amides *For more details, please refer to the PDF materials or feel free to contact us.

• Contract manufacturing

Our company actively engages in the contract synthesis of amino acids with special structures, specializing in the chemical synthesis of amino acids with high chemical and optical purity. > We have a track record of synthesis on a kg scale. We apply various synthesis methods depending on the structure of the target compound, including representative synthesis methods such as synthesis from acetamido malonic acid esters and the Schollkopf method. We also accept contract synthesis of short-chain peptides containing special amino acids. 【Examples of Achievements (Excerpt)】 ■ Linear alkyl α-amino acids ■ Bulk production of special amino acids ■ Lys isostere ■ Fluorine-containing Phe and homoPhe derivatives *For more details, please refer to the PDF document or feel free to contact us.

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Founded in 1845 as Watanabe Jurodo, our company started as a drug wholesaler. After changing our name to Watanabe Chemical Industries, we transitioned from manufacturing and selling general industrial chemicals and food additives to specializing in the production and sale of amino acid and peptide synthesis reagents. As the third category of pharmaceuticals following low molecular weight drugs and antibody drugs, medium molecular weight drugs are gaining attention, particularly peptide drugs, especially cyclic peptides, which are attracting significant expectations and interest. In light of these developments, our company offers approximately 3,000 peptide synthesis reagents, primarily focusing on Fmoc amino acids and Boc amino acids, and we are committed to supporting your drug discovery research. 【Business Activities】 ■ Manufacturing and sales of peptide synthesis reagents and amino acid derivatives *For more details, please refer to the PDF document or feel free to contact us.

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We provide '(Boc)2O', which is difficult to handle due to issues such as "melting during work at a melting point of 20-24°C" and "solidifying in the container making it impossible to take out," in a powdered form that is easy to measure. Fine adjustments to the weight can also be easily made. Please feel free to contact us. 【Features】 ■ Wide mouth for easy scooping with a spoon, making weighing very easy ■ The fine particles melt quickly, making it suitable for those who need to dissolve it for use *For more details, please download the PDF or feel free to contact us.

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