ブレインビジョン List of Products and Services

The latest high-end, high-frequency, high-resolution ultrasound imaging system for small animals, VINNO 6 LAB, developed by YEERAN, a company that has been developing ultrasound diagnostic devices for small animals for many years, enables non-invasive and continuous analysis, as well as quantitative analysis of tissue structure and blood flow velocity with high-resolution image quality. Key Features: - Portable color Doppler ultrasound system - Achieves a system response frequency of 25 MHz through the unique RF platform technology of the VINNO series - Supports high-frequency probes up to 23 MHz - Equipped with a 15-inch high-resolution, high-definition display and an 8-inch touchscreen operation panel

• High Speed Camera

A state-of-the-art ultrasound imaging device that achieves deep observation depth and high temporal resolution, capable of mapping down to micron-level capillaries. When used in conjunction with ultrasound contrast agents (microbubbles), it achieves spatial resolution below 10 microns, enabling measurements of capillary distribution and blood flow velocity not only in the deep brain of rats and mice but also in the spinal cord, kidneys, liver, and tumors. This advanced ultrasound echo device is equipped with a variety of measurement functions suitable for observing mouse heart function and can be optimally utilized for various research topics, including tumors, neurological diseases, vascular issues, vascular plaques, coronary systems, kidney diseases, cellular drug research, brain function, and drug efficacy evaluation.

• Other microscopes

A light source that can simultaneously or alternately illuminate two different wavelengths of LEDs with high output and high stability. It allows for the selection of the minimum necessary wavelengths from a wide range of LEDs, from 405nm to IR. The replacement or expansion of LEDs is easy, and it is an LED light source for imaging that includes a light feedback/current regulation circuit. It is ideal not only for general fluorescence microscopes but also for wide-field illumination. Made in Japan, it offers low prices and reliable support.

• Other physicochemical equipment
• Optical microscope
• Other lighting equipment

This is a device that measures the contraction force of string-like cardiac tissue composed of cardiomyocytes in real-time. It allows for easy analysis of the toxicity and efficacy of drugs on the contraction force of cardiomyocytes. The production of string-like cardiac tissue is easy in a dedicated bioreactor. Research on both acute and chronic phases is also possible.

• Other medical supplies and cosmetics manufacturing machines
• Other Analysis
• Other measurement and measuring equipment

By aligning cultured cardiomyocytes, a sheet can be constructed that reproduces anisotropic excitation propagation similar to cardiac tissue. Anisotropic cardiomyocyte sheets are electrically stable and have a low incidence of reentry. The incidence of reentry induced by drug action in anisotropic cardiomyocyte sheets shows a high correlation with clinical data. The quantification of "drug-induced arrhythmogenic effects," which was difficult with existing testing methods, becomes possible with anisotropic cardiomyocyte sheets. References: Biomaterials 34, 8878–8886 (2013) DOI: 10.1016/j.biomaterials.2013.07.039 Adv Mater. 2017 Jan;29(1) DOI: 10.1002/adma.201602448

• Other medical supplies and cosmetic manufacturing materials
• Culture vessel
• Patch clamp system

With low magnification and a wide field of view, it is easy to measure the membrane potential of cells and the dynamics of calcium ions. It is ideal for imaging neural activity both in vivo and in vitro, as well as isolated heart specimens and cultured cell sheets. It is utilized in research institutions such as universities around the world, generating numerous research papers. Additionally, it can be applied to cutting-edge technology for visualizing electric fields generated within microelectronic circuits.

• Optical microscope
• High Speed Camera
• Other measurement, recording and measuring instruments

By simply placing the culture plate on this device, the heart rate and contraction time of cultured cardiomyocytes can be measured non-invasively and without staining. The measurement results are displayed in real-time as waveforms, and the number of beats and contraction time are automatically detected with the push of a button. It has built-in temperature control and a plate movement mechanism. Compact and lightweight, it is ideal for personal use. Please use it for examining the culture conditions of cardiomyocytes or for preliminary tests of cardiotoxicity assays for compounds.

• Analytical Equipment and Devices
• Other measurement, recording and measuring instruments

● World-class brightness macro fluorescence microscope ● Can also be utilized as a fluorescence branching device capable of wide-field fluorescence measurement ● Up to 4 cameras can be connected ● Built-in function for adjusting the angle of the dichroic mirror to adjust the camera field of view ● The upright type can tilt the optical axis (optional) ● Easy exchange of objective lenses via a revolver ● The inverted type is optimal for wide-field imaging of cultured cells ● Reduces the number of additions for flavin fluorescence imaging ● Capable of various FRET fluorescence measurements in wide-field ● Enables high-sensitivity and high spatial resolution GCaMP mapping in wide-field ● Enables high-sensitivity and high spatial resolution calcium imaging in wide-field ● Essential for membrane potential optical measurements at low magnification ● For high-speed simultaneous measurement of membrane potential and Ca2+ ion dynamics in Langendorff-perfused hearts ● For membrane potential mapping and measurement of Ca2+ ion dynamics in iPS cell-derived cardiomyocytes ● Enables high-speed screening through self-fluorescence observation of microbial colonies

• Optical microscope
• Analytical Equipment
• Other Analysis