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Isothermal Titration Calorimeter (Affinity ITC)
An Isothermal Titration Calorimeter (ITC) is a device that detects the heat changes associated with titration at a constant temperature, primarily used for analyzing molecular interactions. It measures the minute heat changes that occur when molecules bind together, allowing for the determination of binding ratio (n), binding constant (Ka), and the enthalpy change of binding (ΔH) from the resulting titration curve.