TA Instruments Japan List of Products and Services

The Isothermal Titration Calorimeter (ITC) is a device that detects the heat changes associated with titration at a constant temperature and is primarily used for analyzing molecular interactions. It measures the minute heat changes that occur when molecules bind to each other, allowing for the determination of binding ratio (n), binding constant (Ka), and the enthalpy change of binding (ΔH) from the resulting titration curve. Affinity ITC is an isothermal titration calorimeter that provides high sensitivity, high reproducibility, and advanced ITC technology in life science research environments. With AccuShot technology, it delivers precise amounts of titrant to the appropriate location, and the FlexSpin stirring function achieves efficient mixing and high sensitivity. The automatic cleaning function prevents contamination between samples. It offers the option of standard capacity (1.0 mL) or low capacity cells (190 µL), and a temperature-controlled auto-sampler for 96 wells is also available.

TAM offers the highest level of sensitivity, flexibility, and performance. By using a highly sensitive microcalorimeter along with various accessories, it precisely controls various experimental conditions. Up to four calorimeters can be used simultaneously, allowing for repeated experiments and a variety of experiments to be conducted. Additionally, its modular design allows for the addition of multiple calorimeters, enhancing sample processing capacity and functionality. Adding a multi-calorimeter with six mini-calorimeters significantly improves sample throughput. The TAM 4 employs patented thermostat technology, controlling the temperature of the liquid constant temperature bath with an accuracy of 0.0001±730°C. There are three operating modes: isothermal, step isothermal, and temperature scanning mode.

TA Instruments continues to be the leading company in the world of DSC with innovative and exceptional technology. It provides reliable data and enhances workflow and productivity in laboratories. Material property analysis is essential at all stages of product design, manufacturing, processing, and application. Differential Scanning Calorimetry (DSC) is the most widely used thermal analysis instrument for evaluating the physical properties of a wide range of materials, including polymers, pharmaceuticals, food, biomaterials, organic compounds, inorganic compounds, and composites.

TA Instruments continues to be the leading company in the world of DSC with innovative and outstanding technology. It provides reliable data and enhances workflow and productivity in laboratories. Material property analysis is essential at all stages of product design, manufacturing, processing, and application. Differential Scanning Calorimetry (DSC) is the most widely used thermal analysis instrument for evaluating the physical properties of a wide range of materials, including polymers, pharmaceuticals, food, biomaterials, organic compounds, inorganic compounds, and composites.

Measurement capabilities offered by TA Instruments ☆ Thermal analysis / glass transition, crystallization, thermogravimetric analysis, curing reactions, expansion rate, thermal conductivity, shrinkage rate, effects of moisture, etc. ☆ Viscoelastic measurement (rheology) / viscoelasticity, modulus of elasticity, viscosity, stress relaxation, creep, master curve, residual strain, molecular weight, molecular weight distribution, etc. ☆ Microcalorimetry / intermolecular interactions, crystallization, amorphousness, aggregation/precipitation, dispersibility, solubility, compatibility, wettability, stability, adsorption, etc. ☆ Fatigue testing / tensile strength, temperature dependence, viscoelasticity, modulus of elasticity, viscosity, stress relaxation, creep, master curve, residual strain, etc.

Measurement capabilities offered by TA Instruments ☆ Thermal analysis / glass transition, crystallization, thermogravimetric analysis, curing reactions, expansion rate, thermal conductivity, shrinkage rate, effects of moisture, etc. ☆ Viscoelastic measurements (rheology) / viscoelasticity, elastic modulus, viscosity, stress relaxation, creep, master curve, residual strain, molecular weight, molecular weight distribution, etc. ☆ Microcalorimetry / intermolecular interactions, crystallization, amorphousness, aggregation/precipitation, dispersibility, solubility, compatibility, wettability, stability, adsorption, etc. ☆ Fatigue testing / tensile strength, temperature dependence, viscoelasticity, elastic modulus, viscosity, stress relaxation, creep, master curve, residual strain, etc.

Measurement capabilities offered by TA Instruments ☆ Thermal analysis / glass transition, crystallization, thermogravimetric analysis, curing reactions, expansion rate, thermal conductivity, shrinkage rate, effects of moisture, etc. ☆ Viscoelastic measurements (rheology, rheometers) / viscoelasticity, elastic modulus, viscosity, stress relaxation, creep, master curves, residual strain, molecular weight, molecular weight distribution, etc. ☆ Microcalorimetry / intermolecular interactions, crystallization, amorphousness, aggregation/precipitation, dispersibility, solubility, compatibility, wettability, stability, adsorption, etc. ☆ Fatigue testing / tensile strength, temperature dependence, viscoelasticity, elastic modulus, viscosity, stress relaxation, creep, master curves, residual strain, etc.

The DSC measurements conducted with microscope accessories provide insights through multiple applications to better understand the properties and behaviors of materials. It is possible to capture images related to crystallization and melting transitions, flow of materials above the glass transition and melting points, phase transitions, and volume dimensional changes associated with evaporation and sublimation. Visual observation of color changes and other appearance alterations is used in combination with DSC data to gain a deeper understanding of the material being analyzed.

Data Content This is a PDF version of the lecture materials from YouTube, converted for easier viewing. The video consists of a total of 12 pages and provides an easy-to-understand explanation for beginners about: - Principles - Analytical methods - Enthalpy relaxation (recovery) I think it might be difficult to understand with just the lecture materials, so please also refer to the YouTube videos below. YouTube TA Summary Site: https://www.youtube.com/channel/UCk3XzqRdsNQz1hJlqKrfujQ DSC Basics Part 1: https://www.youtube.com/watch?v=DbGpordpweg

Data Content This is a PDF version of the lecture materials from YouTube, converted for easier viewing. The video consists of a total of 13 pages and provides an easy-to-understand explanation for beginners about DSC, including: - Glass transition - Crystalline polymers - Temperature-modulated DSC (MDSC) I think it may be difficult to understand with just the lecture materials, so please also refer to the YouTube video below. YouTube TA Summary Site: https://www.youtube.com/channel/UCk3XzqRdsNQz1hJlqKrfujQ

Data Content This is a PDF version of the lecture materials from YouTube, converted for easier viewing. The video consists of a total of 14 pages and provides easy-to-understand explanations for beginners on the following topics related to DSC: - Glass transition - Crystalline polymers - Temperature-modulated DSC (MDSC) I think it might be difficult to understand with just the lecture materials, so please also refer to the YouTube videos below. YouTube TA Summary Site: https://www.youtube.com/channel/UCk3XzqRdsNQz1hJlqKrfujQ DSC Basics Part 3: https://www.youtube.com/watch?v=wWE7fOx7hD4

The TA Instruments RS-DSC (Rapid Screening Differential Scanning Calorimeter) is a device that brings innovation to the thermal stability testing of biopharmaceuticals. The RS-DSC enables laboratories to make more informed decisions and shorten time to market through high efficiency and streamlined analysis. Features of the RS-DSC: ■ Acceleration of thermal stability testing: Analyzes up to 24 samples simultaneously, providing detailed insights quickly. It also simplifies the characterization of high-concentration pharmaceuticals. ■ Improved efficiency: Utilizes disposable MFC (microfluidic chips) to operate efficiently with samples of less than 15μl. It eliminates the hassle of sample dilution and equipment cleaning, reducing contamination risks. ■ Informed decision-making: The NanoAnalyze software processes vast amounts of data, providing detailed and accurate insights into the thermal stability and thermodynamic properties of molecules.

In the pharmaceutical industry, the study of pharmacokinetics is a crucial factor that influences the success of new drug development. Understanding the absorption, distribution, metabolism, and excretion (ADME) of drugs is essential for evaluating their efficacy and safety. In particular, it is necessary to accurately grasp the solubility, stability, and interactions of drugs. The TAM IV (calorimeter) effectively supports pharmacokinetic research by providing high sensitivity and precise temperature control to analyze the interactions between drugs and biomolecules in detail. 【Application Scenarios】 * Drug solubility testing * Analysis of drug-protein binding * Evaluation of formulation stability * Monitoring of crystallization processes 【Effects of Implementation】 * Increased efficiency in drug development * Improved quality of pharmaceuticals * Enhanced reliability of research data

In the field of materials science, accurately evaluating the thermal properties of materials is crucial for improving product quality and research and development. In particular, understanding the thermal stability, reaction heat, and phase changes of materials is essential for optimizing material design and manufacturing processes. The isothermal calorimeter TAM IV contributes to addressing these challenges by providing high-precision measurements and a variety of experimental conditions. 【Application Scenarios】 - Evaluation of thermal properties of polymers - Measurement of curing reactions in composite materials - Assessment of thermal stability of elastomers - Real-time monitoring of reaction behavior under controlled atmospheres 【Effects of Implementation】 - Detailed understanding of thermal behavior of materials - Quality control and improvement of products - Increased efficiency in research and development - Enhanced reliability of experimental data

In the field of biotechnology, particularly in the study of cellular metabolism, it is crucial to accurately grasp cellular activity in real-time. The metabolic processes of cells are highly complex, and even slight changes can significantly impact research outcomes. The isothermal calorimeter TAM IV enables precise measurement of minute thermal changes associated with cellular metabolic activity, allowing for a detailed understanding of the state of cell activity. This enables researchers to conduct analyses based on more accurate data. 【Application Scenarios】 - Cell culture - Analysis of metabolic pathways - Measurement of drug effects - Evaluation of cell survival rates 【Effects of Implementation】 - Detailed information on cellular metabolism is obtained - Reproducibility of experiments is improved - Contributes to the efficiency of research

In battery research, the evaluation of battery performance and the elucidation of degradation mechanisms are essential for improving energy efficiency and ensuring safety. In particular, measuring the reaction heat and heat generation of battery materials is important for understanding the energy behavior during the charge and discharge processes of batteries. The isothermal calorimeter TAM IV measures the reactions of battery materials in real-time and contributes to solving challenges in battery research. 【Application Scenarios】 * Measurement of reaction heat of battery materials * Evaluation of charge and discharge reactions of batteries * Elucidation of battery degradation mechanisms 【Effects of Introduction】 * Improved accuracy of battery performance evaluation * Enhanced safety of batteries * Increased efficiency in research and development

In the cosmetics industry, evaluating the stability of ingredients is crucial for maintaining product quality. It is necessary to accurately understand changes in ingredients due to temperature fluctuations and the passage of time to prevent product alteration and deterioration. TAM IV provides important information for assessing product stability by measuring the reactions of cosmetic ingredients in real-time. 【Usage Scenarios】 - Formulation considerations for cosmetics - Quality control of products - Prediction of shelf life 【Benefits of Implementation】 - Improvement in product quality - Gaining customer trust - Reduction in product development time

In the field of agriculture, it is important to assess soil quality and find optimal fertilizers and management methods. By accurately understanding the condition of the soil, we can promote crop growth and aim for increased yields. Understanding microbial activity and chemical reactions in the soil is essential for maintaining soil health and practicing sustainable agriculture. The isothermal calorimeter TAM IV allows for precise measurement of various reactions in the soil and enables detailed analysis of soil conditions. 【Application Scenarios】 - Decomposition of organic matter in the soil - Measurement of fertilizer effectiveness - Evaluation of microbial activity - Measurement of soil amendment effectiveness 【Benefits of Implementation】 - Detailed understanding of soil conditions - Selection of optimal fertilizers and management methods - Increased yields - Realization of sustainable agriculture

In the field of environmental science, accurately assessing microbial activity is crucial for addressing environmental pollution and conducting biotechnology research. Microbial metabolic activity is influenced by various factors such as temperature and substance concentration, making it challenging to precisely understand their activity. The TAM IV (calorimeter) can evaluate microbial activity in real-time by measuring the minute heat generated by microbial activity with high precision. 【Application Scenarios】 - Evaluation of microbial activity in soil - Assessment of microbial metabolism in water pollution - Monitoring of microorganisms in bioreactors 【Effects of Implementation】 - Quantitative understanding of microbial activity levels - Enhanced understanding of the material decomposition processes by microorganisms in the environment - Efficient process optimization in biotechnology research

In the polymer industry, the optimization of polymerization reactions and quality control are crucial. By accurately understanding the reaction rate, heat generation, and reaction mechanisms, it is possible to find optimal reaction conditions and produce high-quality polymer products. The TAM IV isothermal calorimeter continuously measures the polymerization reaction process in real-time, addressing these challenges. 【Application Scenarios】 * Optimization of polymerization reactions * Measurement of reaction rates * Measurement of heat generation * Elucidation of reaction mechanisms 【Benefits of Implementation】 * Increased efficiency of polymerization reactions * Improved quality control * Acceleration of research and development

In mining, the mineral dissolution process is essential for the efficient extraction of resources and quality management. Accurate understanding of dissolution rates and reaction heat leads to process optimization, cost reduction, and decreased environmental impact. The isothermal calorimeter TAM IV precisely measures the thermal behavior in the mineral dissolution process, contributing to solving these challenges. 【Application Scenarios】 - Optimization of the mineral dissolution process - Measurement of dissolution rates and reaction heat - Quality management 【Effects of Implementation】 - Process efficiency improvement - Cost reduction - Quality enhancement

In the food industry, maintaining product quality and ensuring safety are crucial. Deterioration or degradation of food can lead to changes in taste and texture, as well as potential impacts on safety. The TAM IV isothermal calorimeter supports quality assessment by directly and continuously measuring the reactions of food. 【Application Scenarios】 - Evaluation of food stability - Prediction of shelf life - Assessment of the effects of food additives - Research on food preservation methods 【Benefits of Implementation】 - Early detection of food quality deterioration - Improvement of product quality - Increased efficiency in research and development