Analysis case: Evaluation of substrate decomposition rate and inhibitor efficacy by ITC.

13:00～14:00 Examples of ITC Utilization - Useful Information Beyond Binding Strength - Masayuki Oda, Kyoto Prefectural University The Isothermal Titration Calorimeter (ITC) is a device that detects changes in heat associated with titration at a constant temperature, primarily used for analyzing molecular interactions. It provides information not only about binding strengths such as Ka and Kd of biomacromolecules like proteins, but also about binding ratios and thermodynamic quantities (ΔH, ΔS, etc.). This presentation will introduce how these pieces of information can be useful and applied, based on specific examples. 14:00～14:30 Introduction to Isothermal Titration Calorimetry (ITC) and Differential Scanning Calorimetry (DSC) for Biomacromolecules Minako Maeda, TA Instruments Application Department

13:00～14:00 Analysis of the interaction between sleep substance-synthesizing enzyme and ligand using isothermal titration calorimetry Shigeru Shimamoto, Lecturer, Department of Life Science, College of Science and Engineering, Kinki University Isothermal titration calorimetry (ITC) has the significant advantage of detecting molecular interactions in a form that is closer to the state present in vivo, without the need for chemical modifications, immobilization, or detection probes. Furthermore, it is a method that provides nearly complete thermodynamic parameters related to the interactions. Here, I will introduce the analysis of the interaction between lipocalin-type prostaglandin D synthase (L-PGDS), which acts as a sleep substance-synthesizing enzyme in the mammalian brain, and its ligand, prostaglandin (PG), using ITC, and discuss the elucidation of the enzyme reaction mechanism in conjunction with structural information. 14:00～14:30 Introduction to isothermal titration calorimetry (ITC) and differential scanning calorimetry (DSC) for biomacromolecules Minako Maeda, Applications Department, TA Instruments

On April 2nd (Friday), we will start an online seminar on batteries, inviting Mr. Yoshiyasu Saito from the National Institute of Advanced Industrial Science and Technology, Energy and Environment Division, Energy Conservation Research Department. We hope you find it useful for your research and development of batteries. Additionally, there will be a presentation from our group company, Japan Waters. We look forward to your applications. 【Participation Tool】Zoom *You can also participate via a web browser. (Participation is possible without downloading the Zoom application) Participation fee: Free Please refer to the detailed page for content and application information. We will notify you of the participation details via email one week before the event. Mr. Yoshiyasu Saito, National Institute of Advanced Industrial Science and Technology 【Title】Utilization of Thermal Measurement and Thermal Analysis in Research and Development of Lithium-Ion Batteries Others

★ Announcement of Online Seminar on Pharmaceuticals to be Held on February 10 ★ On February 10, we will hold a seminar on the analysis and evaluation of pharmaceuticals, featuring Dr. Kawakami from the National Institute for Materials Science (Group Leader/Chief Researcher of the Medical Application Soft Matter Group, also a Professor in the Graduate School of Pure and Applied Sciences at Tsukuba University). Additionally, there will be a presentation from our group company, Waters Japan. We look forward to your applications. 【Participation Tool】Zoom *You can also participate via a web browser. (Participation is possible without downloading the Zoom application) Participation Fee: Free Please refer to the detailed page for content and application information. We will notify you of the participation details via email one week before the event. Dr. Wataru Kawakami, National Institute for Materials Science [Title] Thermal Analysis Equipment as a Research Tool for Pharmaceuticals: Advanced Utilization Beyond Mere Evaluation Methods Others