HIGUCHI INC. Product Lineup

ARCOLYS (001230) is an extract obtained from the roots of Neopicrorhiza scrophulariiflora using water and propylene glycol. It was developed as a plant-derived active ingredient with hair root activation effects to improve the root causes of gray hair. It acts on hair root cells, working to suppress oxidative stress in these cells and promote melanin production, thereby helping to restore the original hair color. Efficacy tests have shown that ARCOLYS treatment reduces gray hair, resulting in improvements in users' self-esteem and positive emotions. In Vitro 1) Suppression of oxidative stress - Antioxidant transcription factor NRF-2: +36% - Antioxidant enzyme heme oxygenase: +62% - SLC7A11: +231% - Reactive oxygen species: -12% 2) Promotion of melanin production - Tyrosinase activity: +26% - Melanin production: +28% In Vivo - Proportion of gray hair: -15% - Density of gray hair: -19% - Improvement in gray hair confirmed in subject photographs - Self-esteem: +8% - Negative emotions: -22%