HIGUCHI INC. List of Products and Services

The eyes are said to be the most important part of interpersonal communication. During the COVID-19 pandemic, the market for eye care products has expanded as wearing masks has become the norm. Miralis is an extract obtained from the roots of the gentian, a high-altitude plant, harvested using sustainable methods, and standardized for its active ingredient, gentiopicroside. <Mechanism of Action> It suppresses six aging-promoting pathways and cares for the eyelids (upper part of the eye), tear troughs, under-eye bags, and dark circles. - Glycation suppression - Extracellular matrix aging suppression - Antioxidant - Anti-inflammatory - Lymphatic drainage promotion - Angiogenesis suppression <In Vitro> - NRF2: +21% - VEGF-A: -15% - Collagen 1 synthesis promotion: +76% - Glycation suppression Activation of glyoxalase 1: +35% Suppression of AGE (carboxymethyllysine) production: -111% - UV protection: Elastin protection: +41% <In Vivo> - Eyelid wrinkle depth: -22% - Tear trough depth: -14% - Under-eye bag swelling: -18% - Dark circle color: -14%

Caviar is known as a luxury ingredient, and among them, the eggs of four types of sturgeon—Beluga, Osetra, Sevruga, and Sterlet—are said to produce the highest quality caviar. Caviar is known for its rich nutritional components, and its extract has efficacy in various cosmetics. <Ingredients (Gessener et al., 2002)> - Amino acids, proteins: Arginine, histamine, isoleucine, lysine, methionine - Vitamins: Vitamin C, B vitamins, etc. - Trace elements: Calcium, magnesium, phosphorus, potassium, sodium, etc. <Efficacy> - Moisturizing effect - Regenerative effect - Antioxidant effect

Fiteren Hair Care EGX232 is a complex product that combines extracts from nine effective hair care ingredients. This product contains extracts with effects such as hair growth stimulation, anti-inflammatory properties, antibacterial effects, improved blood circulation, and nutritional components for hair, helping to keep hair and scalp healthy and beautiful. <Roles of Plant Extracts> - It is expected to improve blood flow to the microcirculation and increase blood flow to the hair roots, enhancing the supply of nutrients and oxygen to the hair roots. Extracts from Arnica flowers and Garlic roots: Blood pressure-lowering effects Extract from Lamium album flowers: Blood circulation-promoting effects - It is expected to protect a clean scalp environment. Extracts from Arnica flowers, Burdock roots, Garlic roots, Chamomile flowers, European Pine cones, and Rosemary leaves: Anti-dandruff effects through the antibacterial action against bacteria and fungi related to seborrhea, as well as anti-inflammatory effects. - It is expected to promote hair growth and regulate sebum secretion. Extracts from Arnica flowers, Burdock roots, Garlic roots, Chamomile flowers, and Watercress: Rich in components necessary for hair growth and regulation of sebum secretion. - It is expected to activate the scalp. Extract from English Ivy: Contains saponins and has the function of removing excess sebum.

The Fiteren Hair Conditioning EGX771 is a complex product that promotes overall hair health. Green Tech has carefully selected and combined marine plants that have synergistic and supplementary effectiveness for hair health, developing a complex product that promotes scalp circulation, moisturizes, supports hair growth, and improves cuticles. <Ingredients> Uronic polysaccharides, sulfated polysaccharides, polyphenols, vitamin B group, amino acids, proteins, minerals, salts, etc. - Nutrients for hair follicles Peptides and vitamin B group are expected to have hair growth effects. - Scalp circulation promotion Polysaccharides, fucoidan, fucan, laminarin: blood pressure-lowering effects Polyphenols: improve the mechanical strength of hair. - Hair growth effects Dulse: rich in vitamin B group, which is excellent for hair growth effects. - Hair treatment, cuticle improvement effects, scalp moisturizing effects Sulfated polysaccharides: interact with amino acids in the stratum corneum and hair keratin, protecting while moisturizing the scalp and hair. - Antioxidant and anti-pollution effects Polyphenols derived from Ascophyllum and Sakhalin kelp, and vitamin C derived from wakame and dulse: neutralize reactive oxygen species. Polysaccharides: form a water-soluble film and exhibit barrier functions.

Agrana Starch (Austria) is a leading supplier of various types of starches for fields such as pharmaceuticals, cosmetics, and food. Cross-linked rice starch RICE PO4 has an average particle size of 8μm and a sharp particle size distribution. It is insoluble in water and does not undergo thermal modification, making it an excellent particle for formulation. It has a high oil absorption capacity and can be used to improve the feel of products such as sebum adsorbents and creams. *The particle size of cross-linked corn-derived starch is 25μm.

This product is an upcycled fruit extract made from non-standard mask melons. It is rich in free sugars, a natural moisturizing factor, which hydrates the skin and keeps it supple and healthy. In Vivo: - Skin moisture level After 1 hour: +54% After 6 hours: +36%

<Ectoin Natural Features> Ectoin is a type of cyclic amino acid produced by extremophilic microorganisms (Halomonas) that inhabit salt lakes and deserts. It has 4 moles of bound water per 1 mole of Ectoin, exhibiting cosmotropic properties. This characteristic contributes to the stabilization of interactions between water molecules, forming a hydrocomplex. This hydrocomplex helps stabilize biological structures (such as cells, proteins, enzymes, and nucleic acids) against environmental stresses like temperature changes, high salt concentrations, strong UV radiation, and dehydration. ― About Effectiveness ― Moisturizing Persistence (In-Vivo): Lasts for 1 week. Skin Barrier Function and Protection of Langerhans Cells (In-Vivo): 100% protection. Promotion of Heat Shock Protein Production (In-Vitro), Anti-Pollution Effect (Ex-Vivo), Protection against Blue Light, UV-A, UV-B, IR-A, and Heat, Anti-Aging Effects (In-Vivo): Improvement in Skin Roughness (86% improvement), Wrinkle Depth (32% improvement), Elasticity (82% improvement), Smoothness (61% improvement), Whitening Effect (In-Vivo): Improvement in Skin Pigmentation (25% improvement).

ECTOinOIL(R) is a multifunctional active ingredient composed of 100% naturally derived components. This product can be used with Ectoin in an oil phase and has been developed for sustainable water-smart product development. It can be used in formulations that do not contain water, such as lip balms and oil products. Data as ECTOinOIL (Ectoin Oil): - Skin roughness: -8% - Skin moisture level: +28% - Skin elasticity: +8% Data as Ectoin Natural (Ectoin): Moisture retention (In Vivo): Lasts for 1 week. Skin barrier function and protection of Langerhans cells (In Vivo): 100% protection. Promotion of heat shock protein production (In Vitro), anti-pollution effect (Ex Vivo), protection against blue light, UV, IRA heat, anti-aging effects (In Vivo): skin roughness (86% improvement), wrinkle depth (32% improvement), elasticity (82% improvement), smoothness (61% improvement), whitening effect (In Vivo): skin pigmentation (25% improvement).

This service develops and manufactures extracts from nutrient-rich buds and young shoots tailored to customer needs using Green Tech's patented cryo-extraction method. - Cryo-extraction technology: Production of concentrated young shoot extracts Cryo-extraction is a patented technology by GT. Since extraction is performed in a frozen state, solvents are unnecessary, and extraction can be done without applying heat to the raw materials. Therefore, it is possible to extract plant-derived (active) components in high concentrations. - The most nutrient-rich parts: Young shoots of plants Plant buds and young shoots are rich in nutrients. They contain high concentrations of amino acids, trace elements, phenolic compounds, sugars, and plant growth hormones necessary for plant growth and reproduction. Green Tech's cryo-extraction technology allows for the preservation of nutrient-rich buds and young shoots in a fresh state and enables the extraction of active components in high concentrations.

This product is an enzyme refined from Bacillus subtilis using cutting-edge technology. Mechanism of Action: Skin aging leads to dysfunction between the exfoliation and adhesion mechanisms, resulting in thickening of the stratum corneum and abnormal retention of keratinocytes. The skin becomes saggy and wrinkled. By using PROTEASE (an extracellular enzyme found in the stratum corneum), peptide bonds are cleaved, inducing the dissolution of desmosomes. The processes of desquamation and cell regeneration are enhanced, slowing down skin aging. The skin's contours become smoother, and nutrient penetration is improved. Efficacy: - Improves the radiance of the complexion by stimulating the desquamation and cell turnover processes. - Smooths the skin's contours, reducing wrinkles and improving blemishes. - Promotes the penetration of nutrients. In Vitro: Approach to the stratum corneum - Adhesion improvement: +49% - Exfoliation promotion effect: +66%

Exosomes are currently a focus in cosmetic ingredients. They have the ability to invigorate skin cells themselves and are well-suited for skin and body care cosmetics, as well as eyelash serums and scalp care products. 【Product Features】 This product is a human stem cell culture supernatant rich in exosomes. The display name is "Human Adipose-Derived Mesenchymal Stem Cell Exosomes." 1. Domestic Manufacturing The entire process from cultivation to productization is carried out in our domestic factory, ensuring high quality. 2. Japanese Donors Adipose stem cells are sourced from healthy Japanese female donors. Donors have been confirmed negative through various tests. 3. Safety Various tests have been conducted on the final product, confirming it is negative. *Only supernatant without cells is used. 4. Evidence Various tests, including cell activation tests, have been conducted to confirm the effectiveness of this ingredient as a cosmetic material. What are Exosomes? Exosomes are small capsules secreted by cells. In recent years, they have gained attention following research reports indicating that they contain effective components. These capsules contain a wealth of information and can deliver necessary information to various locations by moving between cells.

Papain is a protease found in the sap of the papaya tree, named by two scholars in 1879. Papaya has been used in traditional medicine for a long time in the West Indies, America, Africa, and Asia, for digestive disorders, promoting wound healing, and improving erythema. Papain enzyme is used in the fiber industry as a shrinkage preventer for wool and silk, in the food industry for dissolving malt and as a clarifying agent for beer, and for various other applications. Additionally, various studies are being conducted in the cosmetics industry, where it is primarily used as an exfoliating extract. <Functions of Papain in Cosmetics> - Exfoliating effect - Skin regeneration effect - Anti-acne - Hair removal and more.

This is silica derived from bamboo originating in the forests of India. Properties: White powder Particle size: ≦15μm Silica content: ≦87% Mechanism of action: The porous particles of fine micro powder absorb excess sebum and sweat, reducing shine and drying sweat. Effectiveness: - Reduces skin oiliness and controls shine, improving makeup longevity. - Absorbs sweat and keeps the skin dry, thus reducing odor. In Vitro: Artificial sebum absorption capacity: Twice its own weight In Vivo: Antiperspirant effect: -26% (after 4 hours) Odor suppression: -40% (after 4 hours)

This product (Capillary Complex) is an anti-hair loss product made from extracts of four plants. <Active ingredients and effectiveness of each plant> - Clary Sage: Flavonoids, Terpenes, Rosmarinic Acid / Antioxidant function, Anti-inflammatory action - Cinnamon: Tannins / Relaxation effect, Activation effect, Microcirculation promotion effect - Ginkgo: Flavonoids, Diterpenes / Anti-inflammatory action, Vasodilatory effect - Kigelia: Flavonoids, Saponins / Vasodilatory effect, 5α-reductase inhibitory effect In Vivo: - Microcirculation promotion effect: +18% (60 minutes after application) - Sebum secretion suppression effect: -32% (after 60 days of application) - Hair loss suppression effect: -30% (after 60 days of application)

SILIDINE is a plankton extract made from microalgae rich in nutrients, cultivated under excessive oxidative stress. By cultivating it under sunlight, the excessive oxidative stress causes changes in the cellular phenotype, resulting in a high concentration of low molecular weight oligosaccharides and the bioaccumulation of trace elements from the culture medium in the microalgae extract. <Mechanism of Action> - It induces the expression of the endothelin-1 gene. The endothelin-1 gene stimulates the contraction of veins and improves blood retention. It helps improve acne and erythema caused by swelling and inflammation. When applied to the feet, SILIDINE alleviates heaviness and fatigue in the legs. <Efficacy> Reduction of facial redness: 19% improvement (improvement confirmed in 86% of subjects) Reduction of leg swelling: 36% improvement Immediate effects: moisturizing, refreshing sensation, etc.

FERMENT'ACTIVE RASPBERRY is a raspberry fruit extract with an AHA concentration maximized through GREENTECH's fermentation technology. = Mechanism of Action = This product is expected to promote skin regeneration through the exfoliating effects of the high concentration of AHA it contains. = Efficacy = - It leaves the skin hydrated, smooth, and elastic. - It improves the color and shine of hair and skin. = AHA (Citric Acid) Content = It contains 38 times more citric acid than regular raspberries. In hair care, it can be used for moisturizing care.

AHA is known to be effective for peeling but also has irritant properties. GREENTECH discovered that the hibiscus flower containing Senegal acid has effects equivalent to AHA while having a higher content of keto acids, which are less irritating. Its extract, FLOWER ACIDS(R), possesses many efficacies, including peeling effects. = Efficacy = Promotes regeneration of epidermal cells Enhances moisture retention and smooths the skin's surface Low irritation compared to lactic acid Improves skin radiance and evenness Smooths wrinkles and fine lines When applied to hair, increases silkiness and shine. = Mechanism of Action = The high concentration of pyruvic acid (keto acid) contained in FLOWER ACIDS activates cell regeneration by reducing the aggregation of keratinocytes (dissolution of desmosomes) through conversion to lactic acid by epidermal dehydrogenase, thereby improving moisture retention in the upper layers of the epidermis. Pyruvic acid also stimulates the synthesis of collagen and mucopolysaccharides (Jaffary et al., 2016; Moy et al., 1996). = Efficacy = Promotes turnover: 12.5 days (Avg.) Moisturizing effect: +10%

Golden Alga (microalgae) is known for its heavy metal absorption properties. Greentech developed this product by focusing on the beauty effects of gold and the biological characteristics of this microalgae, based on 20 years of microalgae research. The extract made from algae cultured in a medium containing gold has gold included, which suppresses the irritant properties of gold while allowing only its effectiveness to be expressed. = Effectiveness = Golden Alga stimulates the production of specific important molecules related to regeneration, antioxidant effects, whitening, and soothing effects, such as hyaluronic acid, collagen, fibrillin-1 (elastin-like protein), major markers of inflammation, antioxidant response elements (ARE), and skin growth factors. = In Vitro = Filaggrin: +110% Heparin-binding EGF-like growth factor: +60% Glutaredoxin: +50% Heme oxygenase 1: +730% Superoxide dismutase 2: +280% Decorin: +110% Fibrillin 1: +150% Hyaluronan synthase 2: +70% Type 17 collagen: +200% AZGP1: +110% DKK-1: +70% and more.

HOT SPRING WATER is mineral water derived from the volcanoes of Auvergne. The richness of volcanic water comes from its passage through mineral-rich volcanic rocks from the Earth's core before it springs forth. Volcanoes originate from the deepest layers of the Earth. Volcanic rock is rich in minerals and formed from magma. Volcanic materials are highly permeable, and the hot spring water emerges from a water source near the volcano after passing through layers formed by multiple layers of scoria and ash. HOT SPRING WATER is sourced from Montpazier and is rich in minerals derived from volcanic origins. The hot springs in this region have an average temperature of 44°C and contain essential minerals for life, such as iron, selenium, zinc, calcium, magnesium, potassium, and phosphorus. Expected effectiveness: - Strengthens the skin's barrier function - Moisturizes - Calms the skin - Improves mechanical properties - Limits ROS effects - Regulates sebum production

Green clay is a natural mineral from the phyllosilicate family (such as talc and mica). It is composed of hydrated aluminum silicate, and its color appears green due to its high iron oxide content. Its lamellar structure provides very excellent absorption properties. Clay has the ability to absorb liquids such as water and swell like a sponge. Clay has the ability to adsorb, meaning it can fix molecules to its surface. This ability to fix molecules is due to the negative charge of the clay. The negative charge is explained by the presence of minerals (the more concentrated the clay is in inorganic salts, the more negatively charged it becomes). In the Middle Ages, clay was used for healing purposes both externally and internally. Externally, clay was mainly used in the form of masks and poultices, possessing astringent, soothing, and healing properties. 〇 Reports of effectiveness: Adsorption/absorption action (Gubitosa et al., 2019) Cleansing action (Gubitosa et al., 2019) Regenerative action (Valenti et al., 2012) 〇 Components (Williams et al., 2008) Aluminum, calcium, iron, magnesium, silicon, etc.

It is an essential oil (aroma oil) obtained from lemon peels. Lemons are believed to be native to South India, but they are widely used around the world in various applications such as food, beverages, perfumes, and cosmetics, and are well-loved. While many citrus essential oils have relaxing effects, lemon invigorates the mind and body with its fresh scent. The aroma is that of fresh and refreshing lemon itself.

This product is an essential oil (aroma oil) obtained from the flowers of the bitter orange tree. The name "Neroli" is said to have originated in the 17th century when the princess of the Duchy of Nerola in Italy used this essential oil as a perfume. Bitter orange is native to Southeast Asia, and its white flowers have a fragrant aroma. This essential oil is precious, as only a small amount can be obtained from many flowers. Its scent combines the refreshing qualities of citrus with the elegance and splendor of floral notes.

It is an essential oil (aroma oil) obtained from lemongrass leaves. In Southeast Asia, lemongrass is used to flavor dishes and in herbal teas after meals. Lemongrass is native to South India and has long, narrow leaves with a strong fragrance. Its scent is reminiscent of lemon, with a slightly grassy and earthy aroma, and it is also well-known for repelling insects.

This is an essential oil (aroma oil) obtained from geranium (Pelargonium graveolens). Geranium is native to South Africa, and it is said that production for fragrance began in the 19th century. Its scent is sweet and heavy, reminiscent of roses and mint.

It is an essential oil (aroma oil) obtained from the leaves of the tea tree. The tea tree is a tree of the Myrtaceae family that grows wild in Australia, and the Indigenous Aboriginal people have long utilized the medicinal properties of the tea tree as a panacea for infections and wounds. The tea tree is characterized by its immune-modulating effects and is rich in components that have strong antiviral, antibacterial, and antifungal properties. Its scent is characterized by a refreshing, clean, and crisp aroma.

The milk thistle is a biennial plant that can reach a height of 1.5 meters and is characterized by its green leaves with a marble pattern and white veins. It has been known as a medicinal plant for a long time, and since the discovery of a molecule belonging to the flavonoid group called silimarin (silybin) from milk thistle in 1968, it has been used as a liver treatment. This product is an extract derived from seeds that contain the highest concentration of silybin. <Active Ingredients> Silybin ≧ 25%/MS, Taxifolin ≧ 1%/MS Other components include phenolic compounds, oligosaccharides, polysaccharides, amino acids, and proteins. <Cleansing Effects> - Inhibition of the growth of Porphyridium gingivalis - Inhibition of the growth of Streptococcus mutans - Inhibition of the growth of Streptococcus sobrinus

This product is a unique ingredient for supplements that beautify the complexion from within the body. It is a powdered product extracted and refined from Hijiki, which is rich in polyphenols and fucoidan, combining the powerful bioactivity derived from fucoidan and the strong antioxidant properties derived from polyphenols. <Anti-inflammatory Effects> • Suppression of IL-6 • Inhibition of COX-1, COX-2, and LOX 152 activity • Significant reduction of inflammation in the colon during acute colitis among others <Aging Suppression> Sirtuin 1 (SIRT1): +32.4% <Tissue Integrity> Up to 99% inhibition of elastase, collagenase, and tyrosinase activity <Antioxidant Capacity> ORAC 6.0: 28,689 μmol TE/g <Immune Function> Maritech(R) Synergy may induce immune modulation effects, support immune function, and promote healthy, radiant skin.

SETILINE is an extract from fenugreek (koroha) seeds. It contains galactomannan oligosaccharides as its main component, standardized to contain 80% or more of mannose and galactose. Galactomannan oligosaccharides are said to have effects such as suppressing glycation reactions, promoting keratinocyte differentiation, and exhibiting antioxidant properties. This raw material is an extract of koroha seeds that possesses various effects attributed to galactomannan oligosaccharides. <DNA Transcriptome Analysis> - Suppression of ISM1 and HK3 gene expression - Promotion of SOD2 gene expression - Stimulation of SAA1 gene expression - Promotion of hyaluronic acid production - Suppression of MAL gene expression - Suppression of KRT16 gene expression and more. <In Vitro> - Suppression of glycation substance production: -26% - Promotion of keratinocyte differentiation - Epidermal densification: +14% <In Vivo> Improvement in elasticity: +45% (maximum: +214%) Improvement in firmness: +11% (maximum: +93%) Anti-wrinkle: maximum: -37% Smoothing: -30.5% and more.

This is an extract derived from three types of leaves: green tea, white tea, and red tea. This product contains an extract that suppresses damage caused by external oxidation and helps to reduce wrinkles and spots, thanks to the antioxidant power of the three types of black tea leaves. <Source Ingredients> - Green Tea: Rich in epigallocatechin gallate (EGCG), a major type of catechin, which is a kind of polyphenol with antioxidant properties. - White Tea: A precious tea made from buds that were only used by Chinese emperors. It is rich in antioxidants such as epicatechin gallate, epigallocatechin (EPC), and catechins/epicatechins. - Red Tea (Rooibos Tea): Contains a wealth of polyphenols and flavonoids. <Efficacy Component Specification Values> Polyphenols: 60-90% Flavonoids: 1-5% <Effects> It suppresses oxidation reactions caused by free radicals and inhibits lipid peroxidation and MMP at the molecular and cellular levels. It protects tissues from external attacks such as light, pollution, and smoke. In vitro [Suppression of MDA production due to UVB irradiation] - Vitamin E: -46% - TEALINE 0.5%: -40%

Over 100 extracts and oil extracts from 17 regions of France Introduction of 16 data-rich raw materials BIOTILYS: Regulation of skin microbiota, protection booster, skin repair CARICILINE: Moisture content booster for the skin CERNILYS: Improvement of dark circles, brightness enhancement, care around the eyes EPICA: Extracellular matrix protection, improvement of crow's feet EPSILINE: Tanning agent, three types of natural protection HEBELYS: Improvement of skin and mood, anti-aging care for the silver generation HYDRALYS M: Hydration for dry skin, long-lasting moisture retention IAA 50: Slimming, fat breakdown LACTOPHYT: Long-lasting odor control, selective sterilization of odor-causing bacteria LIPACTIF CAMELINE: Nutritional supplementation for the skin, soft-touch oil MYRALYS: Rejuvenation around the eyes, eyelid lifting RAYOLYS: Booster for skin radiance and evenness REVERSKIN: Firming and regeneration booster for the skin SIDILINE: Redness improvement, blood vessel tightening, swelling reduction SILYPUR OC: Oral care, selective sterilization TILICINE: Moisture protection for fragile hair and scalp

This product is an extract fermented with rare cold-resistant bacteria that inhabit the air in France, using the roots of wild gentian organically grown in the high mountains of France. This bacteria is resistant to cold and dry environments, and the holobiosis fermented with it demonstrates effectiveness for dehydrated (water-deficient) and dry (lipid-deficient) skin, showing various efficacy data such as promoting hyaluronic acid synthesis in the epidermis and dermis, antioxidant effects, strengthening barrier functions, and promoting beneficial skin bacteria. Main components: polar lipids, amino acids, loganin acid, swertia amarin. Standardized. In Vitro: Hyaluronic acid synthesis: +62% (keratinocytes), +32% (fibroblasts) CD44 synthesis: +42% (keratinocytes) Lipid synthesis: +147% (keratinocytes) Increase in tight junction-related proteins Increase in basement membrane structural proteins (2 types) Increase in collagen-binding proteins (2 types) Increased expression of antioxidant-related genes (8 types) In Vivo: Skin surface moisture content: +7.3% (all subjects), +12.5% (seborrheic deficiency) Promotion of sebum production: +27% (all), +43% (deficiency) Wrinkle length: -5% Epidermal Staphylococcus: +39% Ralstonia species: +45%

This product is rich in isoflavones, such as daidzein, genistein, and glycitein, which have estrogen-like effects and are derived from dry extracts of soybeans. The estrogen levels in the body decrease due to aging and menopause. The decline in estrogen levels not only increases the risk of osteoporosis but also affects changes in the skin and appearance. <Efficacy of Soy Extract> Regeneration Promotion Effects - Promotion of type I and type III collagen production (genistein, glycitein) - Promotion of fibronectin production (glycitein) - Inhibition of elastase (glycitein) Photoprotection Effects - Inhibition of sunburn cells (UVB) Astringent Effects and more.

Vanilla, belonging to the orchid family, is originally a climbing plant native to tropical America. It grows in Mexico, Guatemala, Venezuela, Guyana, and islands such as Réunion, Comoros, Tahiti, and Madagascar. In the past, in its original habitat of Mexico, vanilla flowers were pollinated by insects. In regions outside of Mexico where vanilla is planted, pollination is done by human hands because insect pollination is not possible. The extract from vanilla fruit is rich in amino acids, polysaccharides, free sugars, minerals, and phenolic compounds, which not only provide fragrance but also offer moisturizing effects, skin quality improvement, antioxidant properties, and antibacterial effects. This product is an extract obtained from organically grown vanilla fruit in Madagascar and has received COSMOS/ECOCERT/HALAL certification.

As society's development accelerates, our bodies are constantly confronted with various environments and stressors to which we have not adapted (e.g., night shifts, social obligations, lack of sleep). Furthermore, this stress disrupts the body's natural rhythms (circadian rhythms). This product promotes improvements in autophagy, melatonin production, antioxidant enzyme production, and stimulation of anti-aging genes by regulating the body clock-related genes (CLOCK, CRY1, PER), addressing tired appearance and stress care. = in Vitro ex Vivo = Regulation of CLOCK, CRY1, PER (adjustment of circadian rhythms) Autophagy LC3(2): +93% Cell stress P53: -20% Melatonin receptor MT1: +24% NFR-2: +85% SIRTUIN1: +56% - Promotion of happiness hormones Oxytocin: +82% Endorphin receptor: +20% Endocannabinoid receptor: +21% = in Vivo = - Improvement of tired appearance Dark circles: -13% Eye bags: -28% Fine wrinkles: -21% Dullness - Yoga-like effects on mood Sense of happiness: +8% Negative emotions: -17%

This product is a low-melting semi-solid avocado oil that has been upcycled using a unique patented method, utilizing the manufacturing residue of avocado oil. The texture is silky and resembles silicone. It is odorless, has a calm color, and excellent oxidative stability, making it a promising alternative to silicone and paraffin. The fatty acid composition is quantified as standard values, and various efficacy can be expected. - Oleic acid: Promotes skin repair and healing - Linolenic acid (5-15%): Improves skin elasticity, suppleness, and moisturizing performance; alleviates symptoms of atopic dermatitis - Palmitic acid (35-45%): Cell regeneration, protective effects on skin and hair - Palmitoleic acid (3-10%): Selective antibacterial, maintains bacterial flora, anti-inflammatory, and repair properties.

Hawthorn Cosmelean is an extract from the flowers of the Western Hawthorn. It contains active ingredients such as vitexin-2-O-rhamnoside: 0.07-0.11%. <Mechanism of Action> - The flavonoids contained in Cosmelean Hawthorn reduce congestion in capillaries and alleviate erythema. - By promoting blood flow, it improves the oxygen levels in the skin. This activates a constant process. <Efficacy> Reduces redness in the skin and brightens it. Unifies skin tone and enhances transparency. Reduces skin discomfort/unpleasant sensations (tightness due to dryness, inflammation). In Vivo: Redness reduction (IR-induced): -6% Redness reduction (UV-induced): -7%

Odesia is a French cosmetic ingredient manufacturer that offers a range of products centered around extracts from algae native to the Brittany region of France. The company's products apply the unique defensive properties that allow algae to survive in various harsh natural environments to cosmetics. Jade AlgaTM is a patented active ingredient rich in native ulvan (sulfated polysaccharide) derived from the green seaweed Ulva Lactuca Variety Armoricana, which inhabits the Brittany coast. It is the only algae with "shape memory capability." The Brittany seaweed is significantly affected by the tides that occur every six hours. Its shape memory capability allows it to withstand repeated cellular deformation (contraction and expansion) caused by the tides without damage. <Efficacy> - Maintenance and recovery of normal stratum corneum arrangement (shape memory technology) - Soft peeling effect - Improved skin and plasticity flexibility - Photoprotection effect - Antioxidant effect

It is an extract of the natural ruby-colored Chosen Gomi, a symbol of beauty and longevity, with a wide range of health benefits. It works on the skin longevity mechanism, leading to vibrant, radiant, and smooth skin. <Active Ingredients> Lignans: ≥10%/DM Longevity extension mechanism Schisandrin: 6-8%/DM Autophagy induction & improvement of skin health lifespan Organic Acids: Citric Acid: 10-15% Malic Acid: 10-15% Tartaric Acid ≥2% Cellular energy production <Efficacy> Unit: % Vitro SIRT6: +181 FOXO3: +104 Anti-inflammatory (NfkB: -14, IL6: -66, PGE2: -87) Antioxidant (ROS: -16, SOD2: +50, Catalase: +104) Mitochondrial activity: +55 Autophagy (LAMP2A: +80, LC3A: +44) Skin barrier (Cornifin A, Occludin: +32, Filaggrin: +160, MDA: -22, Epidermal thickness: +63) Dermis (Elastin: +16, MMP1: -72) Vivo TEWL: -24 Moisture content: +34 Microcirculation: +33 Radiance: +47

SOMITINE is an acidic mannosyl polyglucan derived from purified glucuronic acid obtained through fermentation and mannose. SOMITINE promotes energy metabolism by stimulating ATP levels and recharges the energy readiness of cells. It stimulates cellular activity, basal metabolism, and mitochondrial respiration. SOMITINE enhances cell regeneration and activates the skin to restore its glow. Cellular basal respiration stimulation: +27% Mitochondrial respiration stimulation: +22% ATP: +14%, ADP: +39%, AMP: +18% Skin glow: 205% increase Shine: 50% suppression

Maintaining skin homeostasis relies heavily on intercellular communication. CellCon promotes the production of the intercellular adhesion protein desmoglein-1, actively enhancing the communication necessary for maintaining skin homeostasis. <In Vitro> Promotion of desmoglein-1 gene expression: +150% or more Suppression of sebum production: -15% Increase in skin moisture levels: +13% Suppression of moisture evaporation: -6%

Elaself is a pentapeptide (valine-serine-glycine-isoleucine-arginine) synthesized to mimic a fragment of MFAP4. MFAP4 is necessary for binding fibrillin chains to form microfibrils. These microfibrils are then further modified to become mature elastic fibers (elastin). <In Vitro> MFAP4 gene expression (+30%) Collagen type I gene expression (+30%) Increased intracellular collagen levels in NHDF cells (20-60%) Increased elastin levels <In Vivo> Improvement in skin elasticity (R2: 20%, R5: 25%) Reduction in wrinkle depth (-40%)

Zinnerine is a hexapeptide-2 conjugated with zinc. It has efficacy similar to retinol and is characterized by having equal or greater activity than retinol. In vitro: - Inhibition of hyperkeratosis - Sebum suppression (5α-reductase): over -60% - Inhibition of acne bacteria: approximately -50% - Anti-inflammatory effects - IL1α: -35% - IL-6: over -20% - IL-8: over -20% - Promotion of collagen production (COL1A1 gene expression): +40% In vivo: - Suppression of acne papules: -20% (2 weeks) - Pore contraction: -20% - Improvement of wrinkles: over -30%

To produce 1 kilogram of coffee, 20 kilograms of CO2 are required. However, only 1% of the coffee production uses the beans, while 99% is discarded. Cafe Bueno has achieved zero waste by using this residue as a cosmetic ingredient. This product is available in two grades: unrefined KAFFEOIL and refined KAFFEOIL-R. If you are considering a formulation that emphasizes not only efficacy but also the color and aroma of coffee, we recommend the unrefined KAFFEOIL. For those concerned about odor and color, we recommend the refined KAFFEOIL-R. Efficacy: Nrf2 production: 7 times Repair effect: repairs in 48 hours Hair shine: equivalent to argan oil Protection (prevention and improvement of breakage due to brushing): equivalent to argan.

To produce 1 kilogram of coffee, 20 kilograms of CO2 are required. However, only 1% of the coffee beans are used in production, while 99% is discarded. Cafe Bueno has achieved zero waste by using this residue as a cosmetic ingredient. KAFFEAGE is a powdered extract product that has powdered the water-soluble active ingredients contained in coffee residue. It contains polyphenols and melanoidins. Efficacy: UV Protection: Confirmed absorption in the UV range, suppresses the production of glycation substances caused by UV. SPF Boost: +73.9% (1.8% added) Crow's Feet Wrinkles: -12% Elasticity Improvement: +12.2% Moisturizing Effect: +16.37%

To produce 1 kilogram of coffee, 20 kilograms of CO2 are required. However, only 1% of the coffee beans are used in the production process, while 99% is discarded. Cafe Bueno has achieved zero waste by utilizing this residue as a cosmetic ingredient. KLEANSTANT is a natural anionic surfactant upcycled from coffee by-products, containing potassium palmitate, linoleic acid, polyphenols, tocopherols, and diterpene esters. In addition to its cleansing properties, foaming ability, and antioxidant effects, it also has moisturizing benefits. KLEANSTANT exhibits high foaming performance when the original pH is lowered through neutralization treatment. It shows the best performance at a pH of 5 to 6, and citric acid also contributes to the removal of residues and improvement of emulsification. However, at a pH of 4, foaming ability may decrease.