February 10 ■ Understand from the basics. Easy explanations ■ Accumulation of knowledge beyond AI!? A flavorful physical chemistry model

For the pharmaceutical industry and university pharmacy departments: Materials are currently being provided for the simulation of "continuous production" and the optimization of new drug development.

gPROMS Formulated Products is a modeling tool for solid and powder processes. In cases applied to pharmaceutical processes, it enables consistent performance analysis of the entire system, from active pharmaceutical ingredient (API) manufacturing through formulation processes to risk analysis of oral absorption. Our software has already been implemented by major pharmaceutical companies in Europe, the United States, and Japan. We will send you three simulation materials related to API manufacturing, crystallization, formulation, and oral absorption (Technical Information Association, separate print) by mail (free of charge). 1. Optimal design of API manufacturing and formulation processes using modeling tools 2. Optimization of crystallization processes using simulation and modeling tools 3. Correlation between process parameters and quality characteristics using AI We hope this will be useful as part of further efficiency improvements in "continuous production" and new drug development. If you are interested, please contact us by writing "Request for Process Modeling Materials" in the "Inquiry" section.

• simulator
• Analysis Services

There is a video.

Nova Advanced Cell Science Seminar 2022 [Future Biopharmaceutical Manufacturing] This is a presentation video from the event hosted by Nova Biomedical (September 2022). YouTube video (approximately 16 minutes) Monitoring the operation status of bioreactors with digital twins - Towards building QbD... https://www.youtube.com/watch?v=7JvVQeR7B-I

• simulator
• Other analyses
• Analysis Services

Accelerating further development with digital twins of bioprocesses! There are presentation materials from pharmaceutical, pesticide, and chemical manufacturers.

In the future, in the expanding bio market, why not challenge yourself to improve productivity using the power of software while keeping your existing equipment as is? What products can be created by maximizing the functionality of existing equipment? While satisfying your curiosity about particle size, production volume, and more, we contribute to "reducing development time and costs." By visualizing phenomena that were previously invisible through numbers and graphs, you can deepen your understanding of bioprocesses. <Effects> * Reduction in the number of experiments with the latest modeling features * Shortening of development time through early determination of design space (with validation features) * Risk management during continuous production and scale-up * Optimization of batch crystallization recipes * Monitoring of product quality through digital twins Siemens PSE's bio-related library models (also possible to create digital twins) ■ Bioreactor ■ Fermentation tank ■ Chromatography ■ Filtration ■ Freeze-drying * For more details, please download the PDF, and feel free to reach out if you have any questions.

• simulator
• Analysis Services

Process model library (reaction, crystallization, wet and dry grinding, spray drying, wet and dry granulation, blending, and tablet compression, etc.)

gPROMS Formulated Products is equipped with a library of process models for operations such as reactions, crystallization, wet and dry milling, spray drying, wet and dry granulation, blending, and tablet compression. In case studies applied to pharmaceutical processes, it enables consistent performance analysis of the entire system from active pharmaceutical ingredient (API) manufacturing through formulation processes to oral absorption risk analysis. ■ Solution crystallization analysis ■ Solid-liquid and solid-gas separation, classification, and granulation process analysis ■ Oral absorption analysis This product was developed with the cooperation of major pharmaceutical companies in Europe and the United States. By using mathematical models of raw materials, unit operations, and product performance, it allows for formulation design aimed at optimizing pharmaceuticals and their manufacturing. It enables faster screening of new formulation candidates against quality attributes, including in vivo performance and manufacturability.

• simulator
• Other analyses
• Analysis Services

Pre-testing in simulations allows for risk avoidance in scaling up. We offer consulting services. Monthly contracts available.

The spray dryer allows for the consideration of product quality variation control and equipment scale-up (enlargement) by simulating factors that influence particle size control, moisture content control, and particle shape during the manufacturing process. In modeling, the particle size distribution is calculated based on the Population Balance equation, and the drying process of the particles is also taken into account. Additionally, representing adhesion to the walls is an important requirement in the simulation. With the integration of Siemens' STAR-CCM+, it is possible to analyze the actual gas flow in detail, which can be used for considerations of scale-up and operational improvements. This is an optional feature of gPROMS FormulatedProducts. *For more details, please download the catalog or contact us.

• simulator
• Contract Analysis
• Analysis Services

Visualize continuous processes! For improving quality and reviewing production costs in active pharmaceutical ingredient manufacturing and formulation processes. *We provide support from demo tests to utilization follow-up.

This is a modeling tool developed in collaboration with a U.S. mega-pharma company. Recently, the pharmaceutical industry has been transitioning from batch production to continuous production, and it is being used for process design and control system considerations. It is a model library of gPROMS FormulatedProducts. In continuous production processes, advanced quality management (PAT, QbD, RTRT) becomes possible, as well as the ability to handle small-batch, multi-product production, but at the same time, high-precision process modeling technology becomes essential. If you have any inquiries such as "I want to reduce plant construction costs," "I want to increase production volume at existing plants," or "I want to improve product quality (particle size distribution)," please feel free to contact us! 【Features】 ■ Capable of steady-state and dynamic (dynamic) simulation ■ Easily handles multiple recycle streams ■ Allows for optimization considerations of plant design and operation methods ■ Can identify and estimate process equipment performance from test data ■ Provides graphical representation of batch plant operating procedures ■ Can be linked with crystallization process analysis libraries ■ Can be linked with oral absorption analysis libraries *For more details about the product, please download the PDF from the link below.

• simulator
• Other analyses
• Analysis Services

For increasing production volume, optimizing operations, scale-up design, cost reduction, energy saving, etc.!

<gPROMS FormulatedProducts Crystallization Process Library> It can be used for various considerations and decision-making in production volume enhancement, operational improvement, and process optimization. To build efficient procedures (recipes) in the crystallization process, we will efficiently carry out operations in the following flow and achieve these within a short period (approximately 1 to 2 months). Modeling → Experiment → Model Verification (Parameter Estimation, Validation) → Process Optimization Consideration → Scale-Up Consideration The ability to automatically perform parameter estimation with the tool is a significant factor in reducing the consideration period. Additionally, since it is a kinetic model (expressing mechanisms in mathematical formulas), the number of parameters is kept to a necessary minimum. Furthermore, tools that automatically optimize cooling temperature reduction methods and patterns, the amount and timing of seed crystals, evaporation rates, and heating patterns are powerful, and scale-up may be conducted in conjunction with CFD (Computational Fluid Dynamics) simulations when necessary.

• Contract Analysis

This course is designed to meet the requests of many customers and expands and enriches the content of the previously popular course "Organic Structure Analysis" by including applied topics such as 2D-NMR analysis and chemical decomposition analysis. It is an ideal course for those who have taken the beginner course and want to deepen their understanding of organic structure analysis to aid in research and development.

We will be exhibiting at the "Photonix Light and Laser Technology Exhibition 2025" held at Makuhari Messe starting today! Dates: November 12 (Wednesday) - November 14 (Friday) Venue: Makuhari Messe Official exhibition website: https://www.material-expo.jp/tokyo/ja-jp/visit/photo.html Kantam Ushikata Co., Ltd. Booth number: 47-34 We will be showcasing various laser devices, so please come and visit us! We look forward to seeing you all. DK LASER Co. - Fiber Laser Huaray - Solid Laser IRADION - CO2 Laser El.En. - CO2 Laser Cobolt / HÜBNER Photonics MPB Communications and more.

Our company will be exhibiting at the "Robot and Aerospace Festival Fukushima 2025" to be held at Big Palette Fukushima in Koriyama City, Fukushima Prefecture. ■ November 21 (Friday) Business Exhibition ■ November 22 (Saturday) General Exhibition 【IIDA Exhibits】 Booth Number R-28 - Patent technology "PTFE and Metal Bonding" - "PEEK Gears" contributing to noise reduction and weight reduction - "Resin Bearings" using future materials, etc. At the general exhibition on the 22nd (Saturday), we will offer children the opportunity to experience remote control operation of dinosaur robots. The first 30 children who participate will receive a novelty gift, so we sincerely look forward to your visit. 【Iida Manufacturing Co., Ltd. Fukushima No. 2 Factory】 〒969-1204 21-2 Mizukami, Nukazawa, Motomiya City, Fukushima Prefecture TEL: 0243-64-2320 FAX: 0243-64-2571

[Speaker] Yohei Kawada, Director of the Resource Circulation Promotion Office, Resource Circulation Division, Ministry of the Environment [Key Lecture Content] In Europe, a proposal for the ELV regulation has been made, which includes the mandatory minimum content of recycled plastics in automobiles. Building a recycled plastic market to support the stable production of our country's automobile industry is an urgent and important issue. Through initiatives for collaboration between industry and academia, the Ministry of the Environment has established a "Consortium for Building a Market for Recycled Materials for Automobiles" since last year, aimed at advancing the construction of a recycled plastic market. This lecture will introduce the initiatives of the consortium and the concept of a centralized hub for establishing a stable supply system for recycled plastics for automobiles. [Lecture Items] 1. Current status and "desired state" of recycled plastics for automobiles 2. Direction of discussions for the 2025 Industry-Academia-Government Consortium 3. Current situation analysis and BAU (Business As Usual) scenario 4. Towards the establishment of a supply system for recycled plastics for automobiles 5. Direction for appealing the value of recycled plastics for building the domestic market 6. Q&A / Business card exchange *The content of the lecture may change based on the latest trends.

[Speakers] Ryohta Michino, Senior Manager, Battery Business Division, Itochu Corporation Junmori Arima, Representative Director, Gore Street Japan Co., Ltd. Isao Hasegawa, Group Leader, Power and Energy Division, Mitsubishi Research Institute, Inc. [Key Lecture Content] In the spotlight of energy storage systems, three members of the investment committee of Japan's only dedicated energy storage fund, which has been leading since 2023, will provide insights into the future trends of energy storage systems and batteries in Japan and globally, along with an introduction to their respective companies. [Lecture Items] 1. Introduction to the Energy Storage Fund and Trends in Japan's Energy Storage Systems - Ryohta Michino [13:00–13:55] 2. Lessons from Europe and North America for the Future of Japan's Energy Storage Systems - Junmori Arima [14:00–14:55] 3. Current Status and Impact of Japan's Energy Storage Battery Business Regulations - Isao Hasegawa [15:00–15:55]