[Sending recorded video] Cellca Cell Line Development Technical Update: 9 weeks until RCB

Using Cellca cell line development, over 120 projects have been successfully completed.

Zaltrius is a top provider of cell line development services. It offers cost-effective and highly reliable technology platforms. Cellca cell line development consistently delivers clones for stable research cells that have undergone sufficient characterization. From DNA to research cell banks (RCB) in just 14 weeks, it achieves a minimum monoclonal antibody titer of 5g/L with a scalable fed-batch process.

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Next-generation GMP cell banking

Thorough characterization and documentation of similar master cell banks (MCB) and working cell banks (WCB) are crucial elements that lead to risk reduction and ensure the safety and product quality of all biologically derived products. An experienced team is leveraging CRO expertise to expand services such as cell bank manufacturing. ▪ Manufacturing in a closed system ▪ Quality assurance ▪ Integration into cell line development and biosafety services ▪ For your applications: from mAbs to vaccines

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Integrated services with expertise and industry leadership.

【Top Service Provider】 The foundation for the approval of new biopharmaceuticals is built on a robust analytical data package that demonstrates the safety, purity, and efficacy of the product. BioOutsource's analytical testing package combines physicochemical and biological analytical methods, allowing for detailed characterization tailored to each client. 【Client Management Organization】 Projects are carried out by cross-departmental teams, and client managers provide support and advice with high transparency throughout the entire lifecycle of the client's project. 【Industry-Leading Integrated Services】 By supporting the development and characterization of biopharmaceuticals from preclinical development to commercialization, we provide services tailored to our clients' needs.

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Conducted safety and characterization analysis tests on over 200 Chinese hamster ovary (CHO) cell bank samples.

CHO cells are the most widely used production cell lines in the pharmaceutical industry, and their safety profile has been established for over 20 years. Guidelines for the safety and characterization analysis of CHO production cell lines are harmonized with the International Conference on Harmonisation (ICH) Q5 (R1) "Virus Safety Evaluation of Biotechnology Products Derived from Cell Lines of Human or Animal Origin" and ICH Q5D "Derivation, Characterization, and Production of Cell Lines for the Manufacture of Biological Products (Biotechnology-derived Products | Biologically-derived Products)." Since 2007, Sartorius has conducted safety and characterization testing for over 200 Chinese Hamster Ovary (CHO) cell bank samples. Our researchers possess extensive knowledge and experience and will provide advice on optimal and cost-effective testing strategies that comply with chemical and regulatory requirements. We will also consider the history of the cell lines and raw materials used during bank manufacturing when proposing test packages.

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Introducing comprehensive solutions for safety testing of biological products and viral vaccines.

All biological products must undergo rigorous safety testing at both the development and manufacturing stages to confirm the characteristics of the product and host cells, as well as to ensure non-contamination. ▪ Exceptional technical expertise ▪ Rapid result delivery ▪ Extensive regulatory knowledge ▪ Enhanced quality assurance

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Comprehensively supporting the early development of biopharmaceuticals on an independent platform.

Physical and Chemical, as well as Biological Equivalence of Biosimilars | Similarity Assessment 【Expertise】 Industry-leading experience with over 12 biosimilar molecules and more than 30 biosimilar development companies 【Speed to Market】 Cost-effective results guaranteed through a comprehensive lineup of ready-made assays for the characterization and equivalence | similarity assessment of biosimilars 【Higher Quality Assurance】 Providing the necessary data for submission at the time of application, backed by exceptional regulatory and industry insights

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Chuo Automobile Industry Co., Ltd. will be exhibiting at the "PV EXPO International Photovoltaic Power Generation Exhibition" held at Intex Osaka. A variety of products and technologies will be showcased, ranging from advanced solar cells to the construction, maintenance, and operation of solar power plants, with experts from around the world attending the exhibition. This event, where people and information gather "in real life" from all over the world, is an important platform to accelerate the solar power business through face-to-face interactions. We sincerely look forward to your visit.

The catabolism of branched-chain amino acids (BCAA) is important for the energy metabolism of the whole body, including skeletal muscle, and abnormalities in this process have been noted to be associated with various metabolic diseases. The BCKDH complex, which is responsible for the rate-limiting step of BCAA catabolism, is regulated by the reversible phosphorylation of the E1α subunit by BDK and PPM1K. In this seminar, using skeletal muscle cells, we will present research showing that lauric acid suppresses BCAA oxidation through an O-GlcNAc-sensitive BCKDH regulatory mechanism, and we will introduce the use of a fully automated capillary western system for the analysis of BCKDH phosphorylation and global O-GlcNAcylation.

Applied Corporation will hold a special seminar for those in charge of research and development, AI development, and AX promotion on Wednesday, November 25, 2026, at "STATION Ai" in Nagoya. With the evolution of generative AI and large-scale AI models, the computational environment required for research and development is becoming increasingly sophisticated. This seminar will introduce a high-performance computing environment that supports research and development, focusing on next-generation AI development workstations that can be utilized at the desk side. If you are considering the establishment of a new AI development environment, the introduction or upgrade of GPU workstations, or the efficiency of research and development, please take this opportunity to participate. ■ Date and Time: Wednesday, November 25, 2026, 10:30 AM - 11:30 AM ■ Details and Registration Information: https://mfrdx.applied-g.com/lp/seminar-20261125/

In recent years, the keyword "DX" has been circulating, and various companies are promoting DX initiatives. Among these initiatives, "data utilization" is considered important. Although efforts related to data utilization have increased in recent years, the reality is that few companies are fully leveraging data. To promote "data utilization," it is essential to follow the steps of collection, accumulation, analysis, and business improvement, which are the "steps to utilize data." In this seminar, we will introduce 'ASTERIA Warp,' which enables data integration without coding, 'Dr.Sum,' a DWH that builds a data utilization foundation for companies, and 'MotionBoard,' a BI dashboard that aggregates and visualizes data in real-time, leading to analytical improvements. We will present the steps to advance data utilization through these introductions. This time, you will be able to see a demonstration of the integration of the three solutions: ASTERIA Warp, Dr.Sum, and MotionBoard.

While expectations for the utilization of AI are rising, many companies face challenges such as "a lack of accumulated data for training AI," "necessary information scattered across paper and Excel," and "information fragmented across different systems." AI does not generate value on its own; it only demonstrates its effectiveness when information generated on-site is correctly collected, accumulated, and connected to the necessary departments. Therefore, to successfully utilize AI, it is essential to create an environment where data naturally gathers, flows, and can be utilized. In this seminar, as the first step in promoting DX in the manufacturing industry, we will clearly introduce the following topics with actual demonstrations: - Data collection through the digitization of on-site operations - Automatic utilization of data through system integration - Visualization and expedited decision-making using dashboards - Building a data foundation that leads to AI utilization Participants will experience "how the information input on-site is subsequently utilized" and "why data accumulation is important," while learning about the concept of "connecting DX" required in the AI era and specific ways to advance it.