[End] Innovation Forum 2023 "Simplification of pDNA|mRNA Manufacturing Process by Sartorius"

New standards for integrity testing machines that comply with the latest data integrity and QRM.

The Zaltcheck series is the most widely used in the pharmaceutical industry and has gained the trust of many users as a proven integrity testing device. The Zaltcheck 5 Plus is the latest model in the series, released in 2019. With new technology, we have further enhanced usability, compliance with the latest regulations, and error detection capabilities. It sets a new standard for integrity testing devices that meets the needs of customers seeking higher levels of testing. 【Main Features of the Product】 ■ Specifications that exceed QRM legal requirements - Automatic detection of test setting errors and abnormal test conditions ■ Highest level of data integrity - Customized Linux OS - Data encryption and dual data backup ■ Intuitive and excellent operability - Large touchscreen with a clear viewing angle and intuitive user interface - First in the series to support Japanese display ■ Achievement of Health, Safety, and Environment (HSE) - Explosion-proof specifications (ATEX IECEx & FM certified) that allow safe testing of alcohol-wetted filters *For more details, please contact us or download the PDF materials.

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Bioreactor system for cell line development and process optimization.

The Ambr1515 Generation 2 is a high-throughput "automated micro-scale bioreactor system" that reproduces the performance of laboratory-scale bioreactors. The system consists of single-use vessels, an automated workstation, and enhanced convenience software. It is designed to be installed in a standard biosafety cabinet for aseptic operations, allowing for parallel monitoring and control of 24 or 48 micro-bioreactor cultures. As the manufacturing processes for biopharmaceuticals become more complex and the density of cultures increases, scientists around the world are facing an unprecedented challenge in developing "clone, medium, and process" that meet new demands. The Ambr15 Generation 2 system enhances equipment performance that influences the success of cultures, improves flexibility, and incorporates new features that reflect user feedback. It helps address the aforementioned challenges and supports the acceleration of research by scientists.

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Introducing options and accessories that can be added to the Ambr 15 Generation 2.

You can find the following information in this catalog: ▪ System specifications ▪ Compatible at-line analyzers ▪ Expandable options ▪ Accessories ▪ Ambr 15 microbioreactor (culture vessel) ▪ Plates and chips

• Other physicochemical equipment
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Single-use culture equipment that meets the requirements of the microbial culture process.

【Advantages】 ▪ Specifications designed to accommodate all microbial culture processes ▪ Production of plasmid DNA ▪ Microbial culture bags that have undergone qualification for GMP manufacturing ▪ Improved productivity and user-friendly ▪ Refined process control proven in cell culture

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Rapid at-line analysis chromatography solution

【Features】 ▪ High-speed, high-resolution HPLC analysis for pDNA processes ▪ Acceleration of PD and stabilization of manufacturing and quality through at-line monitoring ▪ Ability to obtain a lot of important information in a short time, with low effort and low cost ▪ Unique monolithic column for CIMac pDNA analysis ▪ User guide, dedicated validated methods, SOPs, and standard materials included

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Fully automated tangential flow filtration system using a closed-loop single-use system suitable for process development to pilot-scale manufacturing.

**Features** - Single-use TFF specifically designed for 1 to 20L scale, providing cost-effective solutions from process development to pilot. - Ready-to-use and closed system, resulting in low bio-burden risk. **Characteristics in ADC Manufacturing** - Automation of three processes: ADC synthesis, precipitate removal, and TFF within a single system. - Reduction of funding, labor, installation space, and process risks, enabling a seamless transition from process development to small-scale commercial ADC manufacturing. - Flexible process sequence control allows for compatibility with various ADC manufacturing protocols. - Stirring optimized for minimal capacity with temperature control.

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Technology for clarification of cell cultures and removal of impurities: Sartoclear Depth Filter

The Zaltclear Depth Filter product family is a cellulose-based filter that contains diatomaceous earth. It is used in the biotechnology and pharmaceutical industries, where high solid removal capabilities are required to meet strict standards. In a dual-layer (DL) format, it can filter cell culture media with a cell density of less than 15×10⁶/mL from the process development stage to the commercial production stage.

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Please check the Japanese version catalog for a significant increase in operability and stirring power!

A high-speed, flexible, and intelligent single-use mixer that accommodates all stirring processes in cGMP-compliant bioprocessing. In mixing processes within the bioprocess environment, quality and efficiency are critically important, and the choice of mixing equipment has a dramatic impact on both. A high-speed, flexible single-use mixer enhances manufacturers' competitiveness and improves productivity.

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A robust, complete, and scalable solution for frozen storage and frozen transportation.

Based on over 15 years of experience in the design of single-use freezing and thawing solutions, we have established Celsius pre-design solutions (PDS) for all processes requiring frozen storage and frozen transport, at both lab scale and manufacturing scale. Celsius PDS separates the downstream process and is equipped with the necessary functions for the safe transport of active pharmaceutical ingredients to pharmaceutical manufacturing facilities.

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Smart condition setting, a genuine end-to-end integrated freeze-thaw system.

A robust, complete, and scalable solution for frozen storage and frozen transport. Sartorius offers lab-scale Celsius solutions for smarter and earlier process decisions in the management of frozen active pharmaceutical ingredients. The Celsius Lab-scale Platform enables the characterization of freezing and thawing within single-use bags of 30 mL to 100 mL, featuring complete scalability up to the commercial-scale Celsius Platform (CFT, FFT, and FFTP).

• Other physicochemical equipment
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Freeze-thaw solutions for seamless scalability to commercial production.

Sartorius, with over 15 years of experience in the design of freeze-thaw solutions, offers lab-scale and manufacturing-scale solutions for all steps of processes requiring frozen storage and frozen transport. This enables biopharmaceutical manufacturers to effectively decouple downstream processes and safely transport active pharmaceutical ingredients to drug manufacturing facilities. The Celsius Platform, equipped with options for blast freezers, horizontal freezers, and vertical plate freezers, provides an end-to-end integrated approach that enables monitoring and control to broadly ensure product quality and integrity.

• Other physicochemical equipment
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We will be holding a seminar as follows during the Next Generation Die Casting Technology Webinar Week 2026. The die casting process plays a very important role in the automotive industry today, contributing to weight reduction, strength, cooling performance, and improved production efficiency. Do you have challenges related to defective products or mold lifespan due to mold temperature management? A non-contact type mold surface temperature monitoring system can achieve stability in quality, accuracy in traceability, and cost reduction. We hope you find it useful along with case studies. Date and Time: July 6, 2026 (Monday) 13:30 - 13:55 Instructor: Product Manager, Sales Engineering Department, Marpos Co., Ltd. Target Audience: - Those involved with die casting products and die casting machines - Those facing challenges in managing mold surface temperature - Those looking to improve traceability in the die casting process - Those wanting to work on cost reduction in the die casting process Registration: Please register through the details and registration button. * An invitation code (free) is required to apply for this event. Please enter the following invitation code on the application site. Invitation Code: K3994296

Japan Cadence Design Systems will exhibit at the "2026 Online Stage 1 of the Human and Vehicle Technology Exhibition." Over 500 exhibitors from both domestic and international markets will gather. You will be able to see cutting-edge technologies and products from a diverse range of companies supporting the future of mobility, including automobile manufacturers, parts suppliers, material and chemical manufacturers, and IT and software companies. We look forward to your visit.

We will hold an online seminar as follows. Do you have challenges with quality control of uniform sheet materials or films? As a new option for the development and manufacturing of films and sheet materials, we will thoroughly explain ultrasonic inline measurement as an alternative to conventional radiation measurement. We will achieve manufacturing quality through non-contact inline measurement without sampling, eliminating the hassle of regulatory compliance. We will propose new options for film production management, incorporating case studies. We sincerely look forward to your participation. Date and Time: August 5, 2026 (Wednesday) 14:00 - 15:00 Instructor: MeSys Product Specialist, Sales Development Department, Marpos Co., Ltd. Target Audience: - Customers involved in the manufacturing and research of films and sheet materials - Customers facing challenges (workload, regulations, etc.) with existing technologies used in film and sheet material production - Individuals researching and investigating new technologies to replace existing ones - Customers involved in coating films and sheets Registration: Please register through the details and registration button.

We will hold an online seminar as follows. This is a practical seminar aimed at evolving monitoring systems for machine tools from "seeing" to "noticing and being able to use," in order to achieve results. We will explain the concepts of tool life management and wear monitoring, operational points after implementation, and how to utilize data for process improvement, along with customer case studies. Date and Time: August 19, 2026 (Wednesday) 14:00 - 15:00 Instructor: Engineer from the Artis Team, Sales Development Department, Marpos Co., Ltd. Target Audience: - Customers who use machine tools on a daily basis - Customers considering the introduction of monitoring systems but want to know the specific process until implementation - Customers researching the latest trends in monitoring systems for machine tools We sincerely look forward to your participation.

Nitto Kohki will exhibit at the "30th Mechanical Components Technology Exhibition [Tokyo]" held at Makuhari Messe Hall 5 from July 9 (Wednesday) to July 11 (Friday). [Booth Number: Hall 5 31-32] At this exhibition, we will showcase a variety of products, including the electric suction hand "e-VEE" with a built-in pump that does not require compressed air, a cordless belt sander, the electric driver "Delvo" that can be mounted on robots, and the "Flow Monitor" that allows for easy visualization of the flow of cooling water in molds and other applications.