Day 3. Oligonucleotide Edition: The Cutting Edge of Biopharmaceutical Analysis - From Basics to Applications by Modality -

Explanation of the measurement of nitrosamine impurities using the high-resolution "Agilent 6546 LC/Q-TOF"!

Angiotensin II receptor blockers (ARBs) are widely used in the treatment of hypertension and heart failure. Recently, it has been found that some ARBs contain carcinogenic nitrosamine impurities, resulting in the recall of many products. Consequently, there is a demand for analytical methods capable of detecting these problematic nitrosamine impurities. This application note describes a high-sensitivity and high-resolution LC/MS/MS method using the "Agilent 6546 LC/Q-TOF" for the detection and quantification of six types of nitrosamines specified by the US FDA, as well as a simultaneous detection method for eleven types of nitrosamine impurities. [Contents] ■ Introduction ■ Experimental Methods ■ Results and Discussion ■ Conclusion ■ References ■ Acknowledgments *For more details, please refer to the PDF document or feel free to contact us.

• Analytical Equipment and Devices

Reliable detection and quantification of nitrosamines and mutagenic impurities.

Due to the presence of unacceptable levels of mutagenic nitrosamine impurities, several pharmaceuticals have recently been recalled. To accurately detect and quantify trace amounts of mutagenic impurities in pharmaceuticals, Agilent offers relevant GC/MS, LC/MS, and high-throughput MS-based analytical techniques. <Challenges in Nitrosamine Analysis> 1. Introducing mass spectrometers requires meeting regulatory requirements, which can be cumbersome. 2. There are many target substances, making it difficult to choose which method/device to use for GC/MS or LC/MS. 3. Due to the high cost of the equipment, results that justify the expense are expected (in terms of cost, operation, speed from introduction to startup, and decisions on outsourcing). 4. It is challenging to foresee whether the risk assessment can be completed by the deadline. <Solutions for Nitrosamine Analysis> Agilent's application guide provides various validated methods from sample preparation to measurement analysis, enabling quick setup and support from introduction to operation. Additionally, regulatory compliance, including data integrity, is achievable.

• Chemicals
• Testing Equipment and Devices
• Analytical Equipment and Devices

A customized LC system that can accommodate all applications, from routine analysis to solutions for specialized workflows.

The "Agilent InfinityLab LC Series" is a high-performance (U)HPLC that expands the possibilities of analysis. We provide customized high-speed and ultra-high-speed LC systems that can accommodate all applications, from routine analysis to solutions for specialized workflows. Our preparative scale HPLC systems achieve high-purity sample purification and excellent recovery rates. We offer LC solutions that cover various fields, achieving excellent chromatography performance while keeping costs down. Since technology is shared across the entire series, we can also respond to changes in application needs. 【Features】 ○ Covers various fields ○ Low cost ○ Achieves excellent chromatography performance ○ Technology shared across the entire series ○ Responds to changes in application needs For more details, please contact us or download the catalog.

• Separation device

Smart software that notifies you when it's time to replace or inspect consumables for analysis machines!

"CrossLab Smart Alerts" is software that monitors the usage of equipment and notifies you via email when it's time to replace consumables or perform inspections. You can receive alerts for all equipment in the lab consolidated into a single email. This provides benefits such as reducing downtime and maintaining the operational status of the equipment. It can be easily installed on various PCs within the lab, and there is no need to connect to the internet. 【Features】 ■ Notifies you when it's time to replace consumables or perform inspections on analytical equipment ■ Useful for preventive maintenance ■ Benefits such as reducing downtime and maintaining the operational status of equipment ■ Easily installable on various PCs within the lab ■ No need to connect to the internet *For more details, please refer to the PDF document or feel free to contact us.

• Software (middle, driver, security, etc.)

Support for the maintenance and operation of laboratory equipment.

To maintain the productivity and efficiency of the lab at its highest level, it is essential to uphold the performance and consistent operation of the equipment. Agilent's service engineers possess the reliable skills, qualifications, and experience to provide repair and maintenance services for all types of equipment, regardless of the manufacturer. It is Agilent, with its industry-leading advanced expertise in chromatography instruments, mass spectrometers, and spectroscopic analyzers, that can meet all of our customers' needs.

• Other measurement, recording and measuring instruments

We will be exhibiting Polysera, jointly developed by Otsuka Chemical and U.M.I., at this exhibition. Polysera not only features excellent microfabrication capabilities, characteristic of POTICON sheet materials, but also possesses high dielectric strength, making it suitable for inspection jigs for electronic components such as semiconductors that require fine and precise processing. On the day of the exhibition, we will showcase finely processed products, so please take this opportunity to stop by.

Ito Machinery Co., Ltd., a subsidiary of Omori Chrome Industry Co., Ltd., will exhibit at the "40th NEPCON Japan - Electronics Development and Manufacturing Expo" held at Tokyo Big Sight. The company will be showcasing within the booth of "Hitachinaka Tech Center, Inc." They plan to introduce custom-made products realized with their trademarked product "Benri Traverse." This exhibition features world-leading electronic components, materials, and manufacturing, assembly, and inspection equipment that support the multifunctionality and high performance of electronic devices. It has established itself as a venue for business discussions with domestic and international manufacturers of electronics, semiconductors, sensors, electronic components, and automotive and electrical equipment. We sincerely look forward to your visit.

Comprehensive Exhibition of Functional Materials Creating "New" Added Value Exhibition: New Functional Materials Exhibition 2026 Booth Number: 3W-F25, 3W-F28 Exhibition Zone: Non-woven Fabric and Functional Paper Zone Exhibition Booth: Japan Non-woven Fabric Association Hirose Paper is a pioneer in high-performance wet non-woven fabrics using synthetic fibers, and we will showcase our main products, including "PPS Non-woven Fabric," "PET Non-woven Fabric," and "Polyolefin Non-woven Fabric." Additionally, this year we plan to introduce for the first time a wet non-woven fabric made from 100% POM (Polyoxymethylene) resin, which has been successfully commercialized globally. POM non-woven fabric is a unique product that boasts high strength, high durability, excellent chemical resistance, low water absorption, quick drying, and hygienic properties, unlike any non-woven fabric available before. You can register for your visit at the following URL. We sincerely look forward to your attendance. https://unifiedsearch.jcdbizmatch.jp/nanotech2026/jp/invitation/dJ1budN2FOGjBaTFo-bZpw

Ichikawa Techno Fabrics Co., Ltd. will be exhibiting at the "New Functional Materials Exhibition 2026" held at Tokyo Big Sight. This exhibition will bring together many products and technologies essential for manufacturing, from materials to processing and devices. Numerous visitors with specific needs seeking solutions to various challenges will attend. Collaboration proposals among exhibitors, as well as between visitors and exhibitors, will also be active. At our booth, we plan to showcase "industrial felt." We look forward to your visit.

The winners of the 8th "Safety Labeling and Human Development Contest" hosted by Max Corporation have been decided. Along with this award ceremony, we will hold a "Safety Exchange Meeting" where each company will present and share their daily safety activities. 【Agenda (Tentative)】 - Award ceremony for the 8th "Safety Labeling and Human Development Contest" - Report on safety activities (from two winning companies) - Lecture on workplace safety activities - Exchange of information on safety activities and labeling, etc. This is a valuable opportunity to learn about the initiatives and safety labeling of other companies! We encourage your participation.