[End] Speaker at the Cell Culture Medium Symposium hosted by Shonan I-Park.

Supporting the development of advanced therapies at every stage, from research and development to application in humans.

Features and Benefits ■ Hydrophobic, forms a monolayer on the water surface, reducing surface adsorption ■ Prevents aggregation and minimizes instability by dispersing uniformly in solution ■ Scavenges free radicals and protects against oxidative stress ■ Functions as a pH buffer and nutrient source, supporting an optimal microenvironment for sustained cell survival ■ Supports cell viability during and after freeze preservation ■ A completely non-human and non-animal derived product, reducing logistical challenges

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Maximization of cell quality characteristics, assurance of reproducible results, reduction of development time.

You can check the following Sartorius culture solutions from this catalog: ■ Stem cell culture media, supplements, and reagents ■ Immune cell culture media ■ Recombinant human albumin and biopreservation ■ Other media and reagents ■ Growth factors and cytokines ■ HEK293 media portfolio ■ Services

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For protein production using CHO cell lines.

■ A wide range of products to accelerate media development ■ Sartorius' global manufacturing network that ensures supply ■ 100% known chemical composition, animal component-free, serum-free, and free of hydrolysates with high reproducibility ■ In addition to ready-to-use catalog products, customizable and highly flexible ■ Highly filterable and soluble media and feeds

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Introducing a medium system for protein production using the CHO system!

The starter kit for the culture system "4Cell XtraCHO" includes all the necessary culture components for cell acclimatization and fed-batch culture at a 3L capacity. When progressing to larger-scale cultures, all individual culture components are available in various forms, both liquid and powder. Using production media and feed media offers benefits such as "eliminating process variability and contamination risks." 【Customer Benefits】 ■ Production Efficiency: Ideal efficiency from bench scale to manufacturing scale ■ Compliance with Regulatory Guidelines: Eliminates process variability and contamination risks ■ Reduces Process Complexity: Facilitates purification *For more details, please refer to the PDF materials or feel free to contact us.

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Next-generation chemical components known to support Vero cell proliferation and virus production.

【Features】 ■ Effective for production: Achieves high cell proliferation and virus production in media with known chemical components ■ Efficient operation: Simplifies filtration and purification in downstream processes, improving virus productivity ■ Safety and regulatory compliance: Reduces variability between processes and minimizes contamination risks

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Excellent results and flexibility with xenofree serum-free medium for lymphocyte culture!

Cell-based immunotherapy is at the forefront of cancer treatment. The most common type of cell-based immunotherapy to date is T-cell therapy (with CAR-T and TIL being the mainstream). The cells used in immunotherapy are generally cultured in a medium supplemented with human serum. The use of serum introduces variability in the process due to individual differences among donors, leading to inconsistencies in cell growth and characteristics. By removing this serum and simplifying the process, regulatory risks are reduced, and the associated logistical burdens are alleviated. Nutri-T eliminates the need for serum by replacing its essential components with specific proteins, lipids, and other small molecules. <Product Overview> ■ Xeno-free ■ Serum-free, no serum supplementation required ■ Compliant with ISO13408 ■ For research use only ■ Developed using cells from actual cancer patients ■ Excellent results with PBMC, TIL, and CAR-T ■ Outstanding results at low initial seeding density

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Xeno-free serum-free medium for hES cells and hiPS cells

NutriStem hPSC XF will be registered with the U.S. FDA Drug Master File (DMF)! NutriStem hPSC XF medium is a xeno-free (XF) medium optimized for the culture of human iPS/ES cells. It contains no animal-derived components and is composed entirely of human-derived proteins. NutriStem hPSC XF Medium has the capability to culture human pluripotent cells without the need for high concentrations of bFGF or other stimulatory growth factors or cytokines, enabling long-term culture while maintaining undifferentiated potential under both feeder-free (Matrigel coated) and on-feeder (MEF, HFF) conditions.

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Redefining the excellence of stem cells and advancing clinical applications: a complete xenofree serum-free system for the proliferation and expansion of hMSCs.

MSC NutriStem XF medium is a xeno-free medium for human mesenchymal stem cells (MSC) derived from various tissues such as bone marrow, fat, and Wharton's jelly. It supports the long-term culture of human MSC while maintaining the fibroblast-like morphology, self-renewal ability, and multipotency observed in normal MSC. MSC Attachment Solution - Xeno-free, purified human fibronectin/fibrinogen - Optimized for serum-free culture - For the proliferation and differentiation of hMSC MSC Dissociation Solution - Ready-to-use, known chemical composition - Recombinant trypsin solution NutriFreez D10 Cryopreservation Solution - Known chemical composition, animal-derived component-free, protein-free - Excellent cell adhesion and viability

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Completely serum-free xenofree medium enables advanced adipogenesis, osteogenesis, and chondrogenesis from hMSCs.

MSCgo Xeno-Free Chondrogenic Differentiation Medium is an innovative xeno-free (free of animal-derived components) and serum-free medium designed to directly induce the differentiation of human mesenchymal stem cells (hMSC) from various sources into chondrocytes. A complete medium is prepared from a basic medium and a supplement mix that includes all the growth factors and supplements necessary for differentiation. Additionally, hMSC isolated and expanded with MSC NutriStemXF can be efficiently induced to differentiate into various cell types (fat, bone, cartilage).

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A cost-effective and efficient standardized supplement designed to adhere human mesenchymal stem cells under serum-free and xeno-free culture conditions.

NutriCoat Attachment Solution is a cell adhesion substrate designed for human mesenchymal stem cells (hMSC) based on human fibrinogen, suitable for serum-free and xeno-free culture. It is optimized for human MSC derived from various tissues cultured in MSC NutriStem XF Medium. Additionally, it supports long-term culture of hMSC and the results of colony-forming unit-fibroblast (CFU-F) assays under serum-free and xeno-free culture conditions. This product is a ready-to-use solution that can be stored at room temperature, making it ideal for experiments in cell therapy research.

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Serum-free, animal-derived component-free, protein-free short-term refrigerated (2-8 °C) cell preservation solution.

The cells stored in this solution demonstrate high recovery rates, normal cell characteristics, and excellent performance due to components that provide pH buffer, osmotic support, energy substrates, and ion concentration. ■ Ready-to-use ■ Known chemical composition, free from animal-derived components, serum-free, and protein-free ■ Provides maximum safety during low-temperature storage (2 - 8°C) ■ Ensures high survival and recovery rates after low-temperature storage ■ Ensures the safety of cells during transport ■ Suppresses necrosis and apoptosis after storage ■ Ideal for a wide range of applications ■ DMF preparation in progress ■ Surpasses competitors in the market

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An all-in-one solution designed for freezing and thawing cells, with a known chemical composition, particularly for cell therapy and clinical applications.

NutriFreez D5 Salt Based Cryopreservation Solution provides an environment that can protect cells even at ultra-low temperatures (-196°C), ensuring high survival rates, recovery rates, and performance for very delicate cells. It is manufactured under current GMP conditions and demonstrates industry-leading performance. This product is optimally formulated, containing 5% DMSO, and does not include antibiotics, antifungals, hormones, growth factors, serum, or proteins.

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Powerful cryopreservation medium optimized for various cells and tissues.

NutriFreez D10 freezing preservation medium is a ready-to-use cell freezing solution that is optimized for multiple cell lines, free of animal-derived components, serum-free, and protein-free. When culturing cells in a serum-free environment, it is important to maintain serum-free conditions during cell freezing and preservation. This product has been shown to have high efficiency in cell viability, proliferation, adhesion (in relevant cell lines), and physiological activity/expression even after freezing and thawing. It has demonstrated superior results compared to serum-containing freezing media and other serum-free products, making it an ideal product for both serum-containing and serum-free applications.

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Growth and transfection media suitable for various HEK cell lines.

【Features】 ▪ Completely known chemical composition ▪ No adaptation from other media or minimal adaptation work required ▪ Stable culture with seed train cultivation ▪ Robust and high performance ▪ For suspension cells ▪ This sample kit (CFV3FB4000) is for research purposes only ▪ Manufacturing use is also possible upon request

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Production medium optimized for gene introduction and viral infection.

【Product Features】 ▪ Uses the highest quality raw materials ▪ Known chemical composition ▪ No adaptation needed from other serum-free media, or minimal adaptation work ▪ Free from animal-derived substances, serum-free, and free from hydrolysates ▪ Manufactured in facilities compliant with ISO 9001 and ISO 13485

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High-quality raw materials for gene cell therapy manufacturing.

■ A smooth transition from the early development stage to the clinical stage with consistent quality and performance ■ Optimal cell proliferation and differentiation ensured by excellent batch-to-batch consistency ■ Regulatory support related to GMP products manufactured in compliance with applicable GMP guidelines

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Next, making cell research and manufacturing easier.

When using cells for large-scale high-quality production, the Sartorius SoloHill microcarriers offer many advantages: ■ Proven track record: Used for over 30 years in the pharmaceutical and healthcare industries for animals and humans. ■ Streamlined solution: Ready to use immediately after sterilization, no prior hydrophilization is required. ■ Ready for immediate use: Sterilized products have a Sterility Assurance Level (SAL) of 10-6, eliminating the need for sterility validation and shortening the manufacturing process.

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Our company will be exhibiting at the "1st Mobility Material Exhibition during High-Performance Material Week." We sincerely look forward to your visit.

[Speaker] Yuichi Ikejiro, Deputy Director, Innovation Center, NTT Docomo Business Inc. [Key Lecture Content] NTT Docomo Business is responsible for corporate ICT business within the NTT Group. It provides a one-stop solution for corporate clients across the entire group, aiming to solve social issues and become a platform for industrial and regional digital transformation (DX) through support for large enterprises and local small and medium-sized enterprises. In this context, the Innovation Center plays a role in exploring and nurturing new business ideas, driving the creation of new businesses and their implementation in society. In this lecture, I would like to introduce the initiatives aimed at creating new businesses utilizing advanced technologies such as AI and IOWN that are promoted by the Innovation Center. [Lecture Items] 1. About NTT Docomo Business / Innovation Center 2. Technology roadmap looking towards 2030 3. Creation of new businesses through open innovation 4. Value creation promoted through design thinking 5. Initiatives for business creation utilizing advanced technologies such as AI, IoT/OT, and IOWN 6. Q&A / Business card exchange

[Speaker] President and CEO of ICT Solution Consulting Co., Ltd. / Creator Takashi Tominaga [Lecture Topics] 1. Review of last year's future predictions 2. Signs of a major upheaval (from 10 news stories) 3. Background of the major upheaval (triggered by Trump 2.0) - The U.S.-China space war and the emergence of disruptors (not innovators but destroyers) - Disruptors' destructive business models (subscription services, overwhelming cost competitiveness) 4. The essence of the major upheaval - The intersection of two massive revolutions (VC revolution and operation revolution) 5. What the major upheaval brings (making industry hierarchy (scale) meaningless) - Industries disintegrating (the risk of existing industries being taken over by platforms, especially in finance, healthcare, administration, national defense, IT, etc.) - Companies disintegrating (the possibility of bankruptcies of companies exceeding one trillion yen, encirclement by disruptors from small and medium-sized enterprises with technology) - Operations disintegrating (operation models using minimal human resources) - Employees disintegrating (the disappearance of the middle class, talent filtering by AI) 6. Overcoming the major upheaval and the concept of transformation (metamorphosis) 7. Q&A and business card exchange

[Instructor] Ryo Sekiguchi, Attorney at Horii Law Office (Japan/New York State) [Key Lecture Content] Against the backdrop of rapid technological advancements and the spread of cashless payments, services related to fund settlement have rapidly diversified, with payment methods utilizing decentralized ledger technology, such as stablecoins, emerging recently. On the other hand, with the diversification of payment and remittance services, providers of fund settlement services are required to comply with various financial regulations from the perspectives of user protection, prevention of fraudulent use, and AML/CFT, among others. These legal regulations have also been frequently amended recently. Most recently, a law partially amending the Fund Settlement Act was enacted in June 2025, with implementation scheduled for this year. Therefore, in the fund settlement business, it is essential to properly understand various legal regulations and to always pay attention to trends in the amendments of these regulations. In this seminar, we will briefly explain the overall picture of financial regulations related to payment and remittance businesses, and we will focus on explaining various remittance and payment services, particularly those parts affected by recent legal amendments.

This is an announcement for a webinar that is a must-see for those considering improving efficiency and stabilizing quality in manufacturing sites. We will be holding the highly praised "Production Guidance System" seminar from IIFES as a special webinar this time. If you have concerns such as: - "I want to eliminate variations in work quality" - "I want to prevent skipping processes and mistakes" - "I want to achieve efficient production even with a labor shortage" this may provide hints for solutions, so we look forward to your registration! 【Date and Time】 February 3, 2026 (Tuesday) 16:00 - 16:40 【Content】 1. Challenges in manufacturing sites and an overview of the guidance system 2. Three features that realize "anyone can do it, without mistakes, efficiently" 3. Case studies of implementation within SANYO Electric 4. Examples of system configuration