[Exhibition Information] 34th Annual Meeting of the Japanese Society of Circulatory Pharmacology

A world-class patch clamp system that is easy to operate for anyone, allowing for simple data acquisition and verification.

This is a patch clamp system of the world's smallest class that can perform gigaseal recordings, optimal for safety testing/toxicity testing/pharmacological testing/screening of compounds at the cellular level in the functional structural analysis of ion channels, research on related diseases, and drug development processes. 【Features】 ■ No need for manual patch clamp experience or difficult operations ■ No need for microscope, vibration table, manipulator, Faraday cage, or puller ■ 20 to 50 data points per day ■ Automation from gigaseal formation to whole cell formation ■ Compatible with voltage-dependent, ligand-dependent, and temperature-dependent channels ■ Options available for research on channel rhodopsins and mechanosensitive channels using light stimulation ■ Measurement of action potentials using current clamp is also possible ■ Supports a wide range of applications and enables rapid assay system development ■ Reduces compound adsorption with borosilicate glass chips ■ Optional temperature control (10 to 50°C), capable of extracellular/intracellular perfusion ■ Can be integrated with amplifiers such as HEKA and Axon *For details, please refer to the catalog available for download in PDF.

• Other physicochemical equipment
• Analytical Equipment
• Patch clamp system

A patch clamp system that incorporates a patch clamp amplifier, achieving miniaturization and reduction of installation costs, allowing for easy data acquisition and verification.

This is a world-class patch clamp system capable of performing gigaseal recordings, optimal for safety testing/toxicity testing/pharmacological testing/screening of compounds at the cellular level in the functional structural analysis of ion channels, research on related diseases, and drug development processes. ■ No experience with manual patch clamping or difficult operations required ■ No need for microscope/vibration isolation table/manipulator/Faraday cage/puller ■ 20 to 50 data points per day ■ Automation from gigaseal formation to whole cell formation ■ Compatible with voltage-dependent and ligand-dependent channels through pipetting ■ Measurement of action potentials using current clamp is also possible ■ Supports a wide range of applications, enabling rapid assay system development ■ Reduces compound adsorption with borosilicate glass chips

• Other physicochemical equipment
• Analytical Equipment
• Patch clamp system

Measurement of impedance and extracellular potential of iPS-derived cardiomyocytes.

This is a hybrid cardiotoxicity screening device capable of impedance measurement and extracellular potential measurement similar to MEA. It can detect not only cardiomyocytes but also the minute contractions of cancer cells and liver cells due to the effects of compounds. ■ Simultaneous measurement of impedance and extracellular potential ■ 96-well simultaneous measurement ■ Label-free measurement ■ Long-term monitoring capability ■ Electrical pacing & optical pacing (optional) ■ Comes with an incubation system (temperature, humidity, and CO2 control) ■ Includes multifunctional and excellent data analysis and graph creation software ■ Validated human iPS cells: iCell, iCell², AXOL CM, Cardiosight-S, MiraCell Cardiomyocytes, etc. ■ Compact desktop size: W20.5 x D18 x H11.7cm / 3.5kg (main unit)

• Other physicochemical equipment
• Other Analysis

The Langeendorff method has been transformed into the latest high-throughput technology, allowing for the measurement of contractile force in cardiomyocytes under physiological conditions similar to the natural environment of cardiac tissue.

The FLEXcyte 96, which transforms the conventional Langendorff method into the latest high-throughput technology, can measure the contractile force (mN/mm²) of cardiomyocytes for cardiotoxicity and safety evaluation, as well as drug screening, under physiological conditions similar to the native cardiac tissue environment, without missing even slight responses to cytotoxicity, regardless of whether in the chronic or acute phase, simultaneously in 96 wells. ■ Simultaneous measurement in 96 wells ■ Label-free measurement ■ Long-term monitoring possible ■ Optical pacing (optional) ■ Comes with an incubation system (temperature, humidity, CO2 control) ■ Includes multifunctional excellent data analysis and graphing software ■ Validated human iPS cells: iCell, iCell², AXOL CM, Cardiosight-S, MiraCell Cardiomyocytes, etc. ■ Compact desktop size: W20.5 x D18 x H11.7cm / 3.5kg (main unit)

• Other physicochemical equipment
• Other Analysis

Under physiological conditions, it is possible to measure the actual contractile force of iPS-derived cardiomyocytes.

Measurement of Contraction Force in Cardiomyocytes Using FLEXcyte96 The FLEXcyte membrane plate features a silicon membrane with a thickness of less than 10μm at the bottom of a 96-well plate. When cardiomyocytes are seeded onto the plate, the weight of the culture medium causes the silicon membrane to deflect, and subsequently, dynamic deflection (up and down movement) occurs due to the synchronized beating of the cardiomyocytes. By measuring the changes in deflection with our proprietary Capacitive Distance Sensor, developed in collaboration with innoVitro, it is possible to calculate mechanical stress and measure the actual contraction force under physiological conditions.

• Other physicochemical equipment
• Other Analysis

Advantech Toyo will be exhibiting at the trade show "JASIS 2026," which will be held at Makuhari Messe International Exhibition Hall. At this exhibition, manufacturers of analytical and scientific instruments will gather to showcase cutting-edge scientific and analytical systems and solutions. At our booth, we will display filter products for microbiological testing and environmental analysis, water quality testing products, pure and ultra-pure water production equipment, and culture-related equipment. Additionally, we will also showcase analytical balances from Mettler Toledo, along with equipment from other well-regarded manufacturers in the industry. Our sales and technical staff will be available to assist with product selection, so please feel free to stop by!

[Speakers] Nomura Research Institute, Ltd. Global Manufacturing Consulting Department Group Manager Hirokazu Shimo Senior Consultant Shoki Tokugawa Senior Consultant Wataru Hashimoto Consultant Masaaki Amano Consultant Tomoya Nakamura [Presentation Items] 1. Key Development Themes of Major OEMs 2. Development Approaches of Each OEM 2-1. Toyota 2-2. Tesla 2-3. Suzuki 2-4. Nissan 2-5. Honda 3. Development Approaches of Suppliers 4. Key Points for Strengthening Development Capabilities 5. Q&A / Business Card Exchange

[Speaker] Ayaka Motomura, Consultant, Business Transformation Unit, NTT Data Management Research Institute [Key Lecture Content] With the advancement of Physical AI, telecommunications carriers have the opportunity to evolve from being "companies that provide lines" to companies that connect and control AI and the physical world in real-time. This seminar will organize the changes in communication demand brought about by Physical AI and the business opportunities for telecommunications carriers, while explaining the role of AIOps as the first step towards entry. Furthermore, it will discuss strategies for monetizing in the Physical AI market by deploying the operational intelligence accumulated through AIOps to network APIs and industry-specific services, as well as the layers that telecommunications carriers should hold. [Lecture Topics] Chapter 1: The Competitive Structure of the "Real World" Rewritten by Physical AI Chapter 2: Reasons Why Opportunities for "Reversal" Arise for Telecommunications Carriers in the Era of Physical AI Chapter 3: The First Step Towards Physical AI Chapter 4: Shifting AIOps from "Defense" to "Offense" Chapter 5: The Layers to Hold in the Era of Physical AI [Q&A / Business Card Exchange]

[Instructor] Partner Ryoji Mori, Eichi Law Office [Key Lecture Content] This lecture will explain the revised Personal Information Protection Act of 2028. The three-year review this time is a major revision, and it is essential to first understand where and how the revisions have been made, as well as the overall picture of the amendments. Next, we will explain the individual amendments that are practically important. The key points are as follows, but it is important to note that both the strengthening and relaxation of obligations are occurring simultaneously, increasing overall complexity. At the time of the lecture, it is expected that subordinate laws and guidelines will not yet be published, but we will discuss points that require attention upon publication. We will distinguish between what is necessary across businesses and what varies by industry. [Lecture Items] 1. Expansion of consent exceptions: Relaxation of the difficulty of obtaining consent and expansion of academic research institutions 2. Statistical exceptions: System content and how to read complex provisions (plus learning about acceptability from controversies) 3. Strengthening regulations on biometric information and children's information: Caution required for age verification 4. Contactable personal-related information: Changes in external transmission responses 5. Review of outsourcing regulations: Addition and removal of obligations for contractors 6. Administrative fines: Narrow target range and low amounts (not worth fearing) 7. Q&A / Business card exchange

[Instructor] Innovation Analyst Andy Kondo [Key Lecture Content] *The latest content will be added (changed) as appropriate based on the on-site survey of IAA Transportation 2026.* From September 15 to 20, 2026, the largest commercial vehicle exhibition in Europe, IAA Transportation, will be held in Hanover, Germany. It is a gathering place for manufacturers of commercial vehicles such as trucks and buses, as well as the parts, energy, and software that support them, occurring every two years. The cost structure of logistics, urban transportation and the environment, energy transition, decarbonization efforts, and a microcosm of the industry will reveal the future business environment just a step ahead. In this seminar, an innovation analyst who has been observing major global exhibitions such as CES and Hannover Messe for many years will report shortly after the event based on on-site coverage. Has autonomous driving become the main focus in commercial vehicles? Where is the energy transition for large vehicles settling in terms of batteries, hydrogen, and alternative fuels? How far have Chinese companies come? Based on photos taken at the venue and observations of actual products, the seminar will delve into the implications for Japanese companies.