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  6. iPS-derived cardiomyocyte contraction measurement system FLEXcyte 96

iPS-derived cardiomyocyte contraction measurement system FLEXcyte 96

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FLEXcyte 96

last updated:Apr 30, 2025

ナニオンテクノロジーズジャパン 東京ラボ(東京大学内)
ナニオンテクノロジーズジャパン 東京ラボ(東京大学内)
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The Langeendorff method has been transformed into the latest high-throughput technology, allowing for the measurement of contractile force in cardiomyocytes under physiological conditions similar to the natural environment of cardiac tissue.

The FLEXcyte 96, which transforms the conventional Langendorff method into the latest high-throughput technology, can measure the contractile force (mN/mm²) of cardiomyocytes for cardiotoxicity and safety evaluation, as well as drug screening, under physiological conditions similar to the native cardiac tissue environment, without missing even slight responses to cytotoxicity, regardless of whether in the chronic or acute phase, simultaneously in 96 wells. ■ Simultaneous measurement in 96 wells ■ Label-free measurement ■ Long-term monitoring possible ■ Optical pacing (optional) ■ Comes with an incubation system (temperature, humidity, CO2 control) ■ Includes multifunctional excellent data analysis and graphing software ■ Validated human iPS cells: iCell, iCell², AXOL CM, Cardiosight-S, MiraCell Cardiomyocytes, etc. ■ Compact desktop size: W20.5 x D18 x H11.7cm / 3.5kg (main unit)

    Other physicochemical equipmentOther Analysis
FLX.jpg

iPS-derived cardiomyocyte contraction measurement system FLEXcyte 96

FLX.jpg
FLX.jpg
  • Related Link - https://youtu.be/aDL8Q00VqdA?t=1602

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basic information

Measurement of Contraction Force in Cardiomyocytes Using FLEXcyte96 The FLEXcyte membrane plate features a silicon membrane at the bottom of a 96-well plate that is less than 10μm thick. When cardiomyocytes are seeded onto the plate, the weight of the culture medium causes the silicon membrane to deflect, and subsequently, dynamic deflection (up and down movement) occurs due to the synchronized beating of the cardiomyocytes. By measuring the changes in deflection with our proprietary Capacitive Distance Sensor, developed in collaboration with innoVitro, it is possible to calculate mechanical stress and measure the actual contraction force under physiological conditions.

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Applications/Examples of results

For more details, please refer to the PDF document or feel free to contact us. For inquiries about products, requests for demos, requests for catalogs, or any other inquiries, please feel free to contact us directly. Mail: info@nanion.jp

Detailed information

  • 2.jpg

    FLEXcyte96 plate

  • 名称未設定-3.jpg

    FLEXcyte96 plate bottom and sensor electrode

  • 名称未設定-4.jpg

    Details of FLEXcyte96

catalog(5)

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Comprehensive Catalog: Electrophysiology Experimental Equipment Catalog vol. 6

Comprehensive Catalog: Electrophysiology Experimental Equipment Catalog vol. 6

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iPS-derived cardiomyocyte measurement system CardioExcyte 96

iPS-derived cardiomyocyte measurement system CardioExcyte 96

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iPS-derived cardiomyocyte contraction measurement system FLEXcyte 96

iPS-derived cardiomyocyte contraction measurement system FLEXcyte 96

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Representative drug evaluation of 【CardioExcyte 96 / FLEXcyte 96】.

Representative drug evaluation of 【CardioExcyte 96 / FLEXcyte 96】.

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List of Applications for CardioExcyte 96

List of Applications for CardioExcyte 96

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News about this product(24)

[Exhibition Information] 99th Annual Meeting of the Japanese Pharmacological Society | Nanion Technologies Japan

  • Seminar・Event

We would like to inform you that we will be exhibiting at the 99th Annual Meeting of the Japanese Pharmacological Society. If you are planning to attend, please be sure to stop by. ❚ 99th Annual Meeting of the Japanese Pharmacological Society Date: March 16 (Monday) - March 18 (Wednesday), 2026 Venue: Tohoku University Kawauchi Campus (Miyagi Prefecture) Exhibition Booth: C105 - 24 For more details, please visit the official website of the 99th Annual Meeting of the Japanese Pharmacological Society. ❚ Products to be Exhibited - Automated Patch Clamp System | Port-a-Patch | Port-a-Patch mini - iPS-Derived Cardiomyocyte Measurement Device | CardioExcyte 96 | FLEXcyte 96 Regarding the Automated Patch Clamp System, we can introduce the "Patchliner," which eliminates the need for pipetting during experiments, is a benchtop device equipped with a dispensing unit, and allows for fully automated continuous measurement of up to 48 cells. Additionally, we can also provide information on the "SyncroPatch 384," which is also adopted by the U.S. FDA and can meet a wide range of needs from small-scale screening projects to high-throughput screening (HTS).

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[Exhibition Information] 17th Annual Meeting of the Japanese Society of Safety Pharmacology

  • Seminar・Event

We would like to inform you that we will be exhibiting at the 17th Annual Meeting of the Japanese Society of Safety Pharmacology. If you are planning to attend, please be sure to stop by. ❚ 17th Annual Meeting of the Japanese Society of Safety Pharmacology Date: February 26 (Thursday) - February 27 (Friday), 2026 Venue: Sonic City (Saitama Prefecture) Exhibition Booth: 10 For more details, please visit the official website of the Japanese Society of Safety Pharmacology. ❚ Products to be exhibited - Automated Patch Clamp System | Port-a-Patch | Port-a-Patch mini - iPS-Derived Cardiomyocyte Measurement Device | CardioExcyte 96 | FLEXcyte 96 Regarding the Automated Patch Clamp System, we can introduce the "Patchliner," which eliminates the need for pipetting during experiments, is a benchtop model equipped with a dispensing device, and allows for fully automated continuous measurement of up to 48 cells. Additionally, we can also present the "SyncroPatch 384," which is adopted by the U.S. FDA and can accommodate a wide range of needs from small-scale screening projects to high-throughput screening (HTS).

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[Workshop Announcement] Electrophysiology Experiment Workshop 2025

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You can experience actual measurements and demonstrations using our various products. For more details about the products, please refer to the related products below. *Capacity: Approximately 10 to 20 people *Due to limited lab space, depending on the number of participants, there may be a possibility of dividing into two sessions, morning and afternoon. *Participants who register for the workshop will be contacted again once the details are finalized.

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[Seminar Announcement] Membrane Physiology Symposium Japan 2025

  • Seminar・Event

We are pleased to announce that Nanion Technologies Japan Co., Ltd. will co-host the Membrane Physiology Symposium Japan 2025 in collaboration with Professor Hideaki Kato's laboratory at the University of Tokyo's Advanced Research Center. Following the symposium, we will also hold a modest networking event, and we warmly invite you to participate. For details on the program and other information, please refer to the related PDF documents. Speakers (in alphabetical order): - Dr. Kenji Akiyoshi | Keio University, Faculty of Pharmacy - Dr. Shuutarou Katsurabayashi | Fukuoka University, Faculty of Pharmacy - Dr. Hideaki Kato | University of Tokyo, Advanced Research Center - Dr. Tomoya Kubota | Osaka University Graduate School of Medicine - Dr. Shin Hamamoto | University of Tokyo Graduate School of Agricultural and Life Sciences - Dr. Yuichiro Miyaoka | Tokyo Metropolitan Institute of Medical Science - Dr. Chai-Ann Ng | Victor Chang Cardiac Research Institute - Dr. Alexandre Santinho | Oria Bioscience - Dr. Will Seibertz | Nanion Technologies GmbH - Dr. Martin Ziller | Nanion Technologies GmbH

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Company information

ナニオンテクノロジーズジャパン

ナニオンテクノロジーズジャパン 東京ラボ(東京大学内)

Pharmaceuticals and Biotechnology

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Nanion Technologies is a scientific instrument manufacturer founded in 2002 in Munich, Germany, specializing in the automation of electrophysiology experiments. We enable the automation of electrophysiology experiments, supporting not only ion channel research but also a wide range of membrane protein-related studies. We offer a broad product lineup, including our industry-leading automated patch clamp system, transporter activity measurement systems, artificial lipid bilayer experimental devices, liposome production devices, and impedance, extracellular potential, and contraction force measurement systems for iPS-derived cardiomyocytes. These systems have been adopted by many universities, pharmaceutical companies, and research institutions both domestically and internationally, and are highly regarded. For inquiries about our products, requests for introductions, demo requests, or catalog requests, please contact us or our authorized distributors. Additionally, feel free to consult us about visiting our Tokyo lab (Meguro Ward) to see the systems and experiments. Mail: info@nanion.jp

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