[Exhibition Information] 17th Annual Meeting of the Japanese Society of Safety Pharmacology

A patch clamp system that incorporates a patch clamp amplifier, achieving miniaturization and reduction of installation costs, allowing for easy data acquisition and verification.

This is a world-class patch clamp system capable of performing gigaseal recordings, optimal for safety testing/toxicity testing/pharmacological testing/screening of compounds at the cellular level in the functional structural analysis of ion channels, research on related diseases, and drug development processes. ■ No experience with manual patch clamping or difficult operations required ■ No need for microscope/vibration isolation table/manipulator/Faraday cage/puller ■ 20 to 50 data points per day ■ Automation from gigaseal formation to whole cell formation ■ Compatible with voltage-dependent and ligand-dependent channels through pipetting ■ Measurement of action potentials using current clamp is also possible ■ Supports a wide range of applications, enabling rapid assay system development ■ Reduces compound adsorption with borosilicate glass chips

• Other physicochemical equipment
• Analytical Equipment
• Patch clamp system

A world-class patch clamp system that is easy to operate for anyone, allowing for simple data acquisition and verification.

This is a patch clamp system of the world's smallest class that can perform gigaseal recordings, optimal for safety testing/toxicity testing/pharmacological testing/screening of compounds at the cellular level in the functional structural analysis of ion channels, research on related diseases, and drug development processes. 【Features】 ■ No need for manual patch clamp experience or difficult operations ■ No need for microscope, vibration table, manipulator, Faraday cage, or puller ■ 20 to 50 data points per day ■ Automation from gigaseal formation to whole cell formation ■ Compatible with voltage-dependent, ligand-dependent, and temperature-dependent channels ■ Options available for research on channel rhodopsins and mechanosensitive channels using light stimulation ■ Measurement of action potentials using current clamp is also possible ■ Supports a wide range of applications and enables rapid assay system development ■ Reduces compound adsorption with borosilicate glass chips ■ Optional temperature control (10 to 50°C), capable of extracellular/intracellular perfusion ■ Can be integrated with amplifiers such as HEKA and Axon *For details, please refer to the catalog available for download in PDF.

• Other physicochemical equipment
• Analytical Equipment
• Patch clamp system

No pipetting operations are required during the experiment. It is equipped with a benchtop dispensing device that can automatically measure up to 48 cells continuously in an auto patch clamp system.

This is a tabletop-sized auto patch clamp system that can simultaneously measure up to 8 cells with giga-seal formation. With easy experimental setup, stable whole-cell recordings, and sophisticated software, it enables highly efficient compound ion channel screening. ■ Equipped with a dispensing device, allowing for fully automated experiments (measurements) ■ Simultaneous measurement of 4 cells / 8 cells (up to 48 cells can be measured continuously) ■ 250 to 600 data points per day ■ Automation from giga-seal formation to whole-cell formation ■ Compatible with voltage-dependent and ligand-dependent channels ■ Measurement of action potentials using current clamp is also possible ■ Dynamic clamp capability (optional) ■ Temperature control and extracellular/intracellular perfusion possible ■ Cooling plate allows for cooling of cells and compounds ■ Borosilicate glass chips reduce compound adsorption ■ Comes with excellent analysis software

• Other physicochemical equipment
• Analytical Equipment
• Patch clamp system

An automated patch clamp system capable of meeting all needs, from small-scale screening projects to high-throughput screening.

Designed to seamlessly integrate fully automated compound screening into the drug discovery process, it provides the best performance in high-throughput screening of ion channels in drug discovery, pharmacology, safety, pharmaceutical research and development, and exploratory screening departments. Additionally, by using the 32-well mode, it can be optimized for small-scale compound screening and projects. ■ Simultaneous measurement of 384 cells ■ 20,000 data points per day ■ High giga-seal success rate ■ Supports a variety of ion channel targets and enables rapid assay system development ■ Measurement of action potentials using current clamp is also possible ■ Extracellular/intracellular perfusion is possible ■ High-speed external solution exchange (up to 110 µl/s) is possible ■ Measurement section and 12 decks can be individually temperature controlled (temperature range: 10–37°C) ■ Compound plate preparation on the deck is possible ■ Single & multi-well chips available (in-house manufactured) ■ Borosilicate glass chips reduce compound adsorption ■ Approximately 8 hours of unmanned operation is possible ■ Comes with powerful analysis software ■ Validated system for CiPA

• Other physicochemical equipment
• Analytical Equipment
• Patch clamp system

Measurement of impedance and extracellular potential of iPS-derived cardiomyocytes.

This is a hybrid cardiotoxicity screening device capable of impedance measurement and extracellular potential measurement similar to MEA. It can detect not only cardiomyocytes but also the minute contractions of cancer cells and liver cells due to the effects of compounds. ■ Simultaneous measurement of impedance and extracellular potential ■ 96-well simultaneous measurement ■ Label-free measurement ■ Long-term monitoring capability ■ Electrical pacing & optical pacing (optional) ■ Comes with an incubation system (temperature, humidity, and CO2 control) ■ Includes multifunctional and excellent data analysis and graph creation software ■ Validated human iPS cells: iCell, iCell², AXOL CM, Cardiosight-S, MiraCell Cardiomyocytes, etc. ■ Compact desktop size: W20.5 x D18 x H11.7cm / 3.5kg (main unit)

• Other physicochemical equipment
• Other Analysis

The Langeendorff method has been transformed into the latest high-throughput technology, allowing for the measurement of contractile force in cardiomyocytes under physiological conditions similar to the natural environment of cardiac tissue.

The FLEXcyte 96, which transforms the conventional Langendorff method into the latest high-throughput technology, can measure the contractile force (mN/mm²) of cardiomyocytes for cardiotoxicity and safety evaluation, as well as drug screening, under physiological conditions similar to the native cardiac tissue environment, without missing even slight responses to cytotoxicity, regardless of whether in the chronic or acute phase, simultaneously in 96 wells. ■ Simultaneous measurement in 96 wells ■ Label-free measurement ■ Long-term monitoring possible ■ Optical pacing (optional) ■ Comes with an incubation system (temperature, humidity, CO2 control) ■ Includes multifunctional excellent data analysis and graphing software ■ Validated human iPS cells: iCell, iCell², AXOL CM, Cardiosight-S, MiraCell Cardiomyocytes, etc. ■ Compact desktop size: W20.5 x D18 x H11.7cm / 3.5kg (main unit)

• Other physicochemical equipment
• Other Analysis

Chuo Automobile Industry Co., Ltd. will be exhibiting at the "PV EXPO International Photovoltaic Power Generation Exhibition" held at Intex Osaka. A variety of products and technologies will be showcased, ranging from advanced solar cells to the construction, maintenance, and operation of solar power plants, with experts from around the world attending the exhibition. This event, where people and information gather "in real life" from all over the world, is an important platform to accelerate the solar power business through face-to-face interactions. We sincerely look forward to your visit.

The catabolism of branched-chain amino acids (BCAA) is important for the energy metabolism of the whole body, including skeletal muscle, and abnormalities in this process have been noted to be associated with various metabolic diseases. The BCKDH complex, which is responsible for the rate-limiting step of BCAA catabolism, is regulated by the reversible phosphorylation of the E1α subunit by BDK and PPM1K. In this seminar, using skeletal muscle cells, we will present research showing that lauric acid suppresses BCAA oxidation through an O-GlcNAc-sensitive BCKDH regulatory mechanism, and we will introduce the use of a fully automated capillary western system for the analysis of BCKDH phosphorylation and global O-GlcNAcylation.

Applied Corporation will hold a special seminar for those in charge of research and development, AI development, and AX promotion on Wednesday, November 25, 2026, at "STATION Ai" in Nagoya. With the evolution of generative AI and large-scale AI models, the computational environment required for research and development is becoming increasingly sophisticated. This seminar will introduce a high-performance computing environment that supports research and development, focusing on next-generation AI development workstations that can be utilized at the desk side. If you are considering the establishment of a new AI development environment, the introduction or upgrade of GPU workstations, or the efficiency of research and development, please take this opportunity to participate. ■ Date and Time: Wednesday, November 25, 2026, 10:30 AM - 11:30 AM ■ Details and Registration Information: https://mfrdx.applied-g.com/lp/seminar-20261125/

In recent years, the keyword "DX" has been circulating, and various companies are promoting DX initiatives. Among these initiatives, "data utilization" is considered important. Although efforts related to data utilization have increased in recent years, the reality is that few companies are fully leveraging data. To promote "data utilization," it is essential to follow the steps of collection, accumulation, analysis, and business improvement, which are the "steps to utilize data." In this seminar, we will introduce 'ASTERIA Warp,' which enables data integration without coding, 'Dr.Sum,' a DWH that builds a data utilization foundation for companies, and 'MotionBoard,' a BI dashboard that aggregates and visualizes data in real-time, leading to analytical improvements. We will present the steps to advance data utilization through these introductions. This time, you will be able to see a demonstration of the integration of the three solutions: ASTERIA Warp, Dr.Sum, and MotionBoard.

While expectations for the utilization of AI are rising, many companies face challenges such as "a lack of accumulated data for training AI," "necessary information scattered across paper and Excel," and "information fragmented across different systems." AI does not generate value on its own; it only demonstrates its effectiveness when information generated on-site is correctly collected, accumulated, and connected to the necessary departments. Therefore, to successfully utilize AI, it is essential to create an environment where data naturally gathers, flows, and can be utilized. In this seminar, as the first step in promoting DX in the manufacturing industry, we will clearly introduce the following topics with actual demonstrations: - Data collection through the digitization of on-site operations - Automatic utilization of data through system integration - Visualization and expedited decision-making using dashboards - Building a data foundation that leads to AI utilization Participants will experience "how the information input on-site is subsequently utilized" and "why data accumulation is important," while learning about the concept of "connecting DX" required in the AI era and specific ways to advance it.